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Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism.
Fertil Steril. 1999 Jul; 72(1):41-6.FS

Abstract

OBJECTIVE

To compare the effectiveness of finasteride and flutamide in the treatment of idiopathic hirsutism.

DESIGN

Randomized study.

SETTING

Department of Gynecological Endocrinology, University of Brescia, Italy.

PATIENT(S)

Forty-six women with idiopathic hirsutism were selected.

INTERVENTION(S)

Patients were assigned randomly to receive 5 mg of finasteride once daily or 250 mg of flutamide twice daily for 12 consecutive months.

MAIN OUTCOME MEASURE(S)

Hirsutism was evaluated at 6 and 12 months of therapy by measuring the Ferriman-Gallwey score and the terminal-hair diameters (microm) taken from different body areas. Blood samples were taken and side effects were monitored during the treatment.

RESULT(S)

Both finasteride and flutamide induced a statistically significant decrease in hirsutism scores and hair diameters at the end of 12 months. Finasteride reduced the Ferriman-Gallwey score by 20.5% at 6 months and by 34.2% at 12 months, and hair diameter by 18.9%-23.6% at 6 months and by 29.6%-37.9% at 12 months. Flutamide reduced the Ferriman-Gallwey score by 26.6% at 6 months and by 50.9% at 12 months, and hair diameter by 22.3%-28.2% at 6 months and by 47.7%-56.5% at 12 months. Flutamide did not induce hormonal variations, whereas finasteride increased T levels by 60% and decreased 3alpha-androstanediol glucuronide by 69.5% at 12 months.

CONCLUSION(S)

Both drugs were effective in the treatment of idiopathic hirsutism, but flutamide was more effective than finasteride.

Authors+Show Affiliations

Department of Gynecological Endocrinology, University of Brescia, Italy.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10428146

Citation

Falsetti, L, and A Gambera. "Comparison of Finasteride and Flutamide in the Treatment of Idiopathic Hirsutism." Fertility and Sterility, vol. 72, no. 1, 1999, pp. 41-6.
Falsetti L, Gambera A. Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism. Fertil Steril. 1999;72(1):41-6.
Falsetti, L., & Gambera, A. (1999). Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism. Fertility and Sterility, 72(1), 41-6.
Falsetti L, Gambera A. Comparison of Finasteride and Flutamide in the Treatment of Idiopathic Hirsutism. Fertil Steril. 1999;72(1):41-6. PubMed PMID: 10428146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism. AU - Falsetti,L, AU - Gambera,A, PY - 1999/7/31/pubmed PY - 1999/7/31/medline PY - 1999/7/31/entrez SP - 41 EP - 6 JF - Fertility and sterility JO - Fertil Steril VL - 72 IS - 1 N2 - OBJECTIVE: To compare the effectiveness of finasteride and flutamide in the treatment of idiopathic hirsutism. DESIGN: Randomized study. SETTING: Department of Gynecological Endocrinology, University of Brescia, Italy. PATIENT(S): Forty-six women with idiopathic hirsutism were selected. INTERVENTION(S): Patients were assigned randomly to receive 5 mg of finasteride once daily or 250 mg of flutamide twice daily for 12 consecutive months. MAIN OUTCOME MEASURE(S): Hirsutism was evaluated at 6 and 12 months of therapy by measuring the Ferriman-Gallwey score and the terminal-hair diameters (microm) taken from different body areas. Blood samples were taken and side effects were monitored during the treatment. RESULT(S): Both finasteride and flutamide induced a statistically significant decrease in hirsutism scores and hair diameters at the end of 12 months. Finasteride reduced the Ferriman-Gallwey score by 20.5% at 6 months and by 34.2% at 12 months, and hair diameter by 18.9%-23.6% at 6 months and by 29.6%-37.9% at 12 months. Flutamide reduced the Ferriman-Gallwey score by 26.6% at 6 months and by 50.9% at 12 months, and hair diameter by 22.3%-28.2% at 6 months and by 47.7%-56.5% at 12 months. Flutamide did not induce hormonal variations, whereas finasteride increased T levels by 60% and decreased 3alpha-androstanediol glucuronide by 69.5% at 12 months. CONCLUSION(S): Both drugs were effective in the treatment of idiopathic hirsutism, but flutamide was more effective than finasteride. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/10428146/Comparison_of_finasteride_and_flutamide_in_the_treatment_of_idiopathic_hirsutism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(99)00183-1 DB - PRIME DP - Unbound Medicine ER -