Abstract
OBJECTIVE
To compare the effectiveness of finasteride and flutamide in the treatment of idiopathic hirsutism.
SETTING
Department of Gynecological Endocrinology, University of Brescia, Italy.
PATIENT(S)
Forty-six women with idiopathic hirsutism were selected.
INTERVENTION(S)
Patients were assigned randomly to receive 5 mg of finasteride once daily or 250 mg of flutamide twice daily for 12 consecutive months.
MAIN OUTCOME MEASURE(S)
Hirsutism was evaluated at 6 and 12 months of therapy by measuring the Ferriman-Gallwey score and the terminal-hair diameters (microm) taken from different body areas. Blood samples were taken and side effects were monitored during the treatment.
RESULT(S)
Both finasteride and flutamide induced a statistically significant decrease in hirsutism scores and hair diameters at the end of 12 months. Finasteride reduced the Ferriman-Gallwey score by 20.5% at 6 months and by 34.2% at 12 months, and hair diameter by 18.9%-23.6% at 6 months and by 29.6%-37.9% at 12 months. Flutamide reduced the Ferriman-Gallwey score by 26.6% at 6 months and by 50.9% at 12 months, and hair diameter by 22.3%-28.2% at 6 months and by 47.7%-56.5% at 12 months. Flutamide did not induce hormonal variations, whereas finasteride increased T levels by 60% and decreased 3alpha-androstanediol glucuronide by 69.5% at 12 months.
CONCLUSION(S)
Both drugs were effective in the treatment of idiopathic hirsutism, but flutamide was more effective than finasteride.
TY - JOUR
T1 - Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism.
AU - Falsetti,L,
AU - Gambera,A,
PY - 1999/7/31/pubmed
PY - 1999/7/31/medline
PY - 1999/7/31/entrez
SP - 41
EP - 6
JF - Fertility and sterility
JO - Fertil Steril
VL - 72
IS - 1
N2 - OBJECTIVE: To compare the effectiveness of finasteride and flutamide in the treatment of idiopathic hirsutism. DESIGN: Randomized study. SETTING: Department of Gynecological Endocrinology, University of Brescia, Italy. PATIENT(S): Forty-six women with idiopathic hirsutism were selected. INTERVENTION(S): Patients were assigned randomly to receive 5 mg of finasteride once daily or 250 mg of flutamide twice daily for 12 consecutive months. MAIN OUTCOME MEASURE(S): Hirsutism was evaluated at 6 and 12 months of therapy by measuring the Ferriman-Gallwey score and the terminal-hair diameters (microm) taken from different body areas. Blood samples were taken and side effects were monitored during the treatment. RESULT(S): Both finasteride and flutamide induced a statistically significant decrease in hirsutism scores and hair diameters at the end of 12 months. Finasteride reduced the Ferriman-Gallwey score by 20.5% at 6 months and by 34.2% at 12 months, and hair diameter by 18.9%-23.6% at 6 months and by 29.6%-37.9% at 12 months. Flutamide reduced the Ferriman-Gallwey score by 26.6% at 6 months and by 50.9% at 12 months, and hair diameter by 22.3%-28.2% at 6 months and by 47.7%-56.5% at 12 months. Flutamide did not induce hormonal variations, whereas finasteride increased T levels by 60% and decreased 3alpha-androstanediol glucuronide by 69.5% at 12 months. CONCLUSION(S): Both drugs were effective in the treatment of idiopathic hirsutism, but flutamide was more effective than finasteride.
SN - 0015-0282
UR - https://www.unboundmedicine.com/medline/citation/10428146/Comparison_of_finasteride_and_flutamide_in_the_treatment_of_idiopathic_hirsutism_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(99)00183-1
DB - PRIME
DP - Unbound Medicine
ER -
