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The effect of topical ciprofloxacin on postoperative otorrhea after tympanostomy tube insertion.
Am J Otol 1999; 20(4):416-20AJ

Abstract

OBJECTIVE

This study aimed to evaluate the effectiveness of prophylactic ciprofloxacin drops in decreasing the incidence of otorrhea after tympanostomy tube insertion.

STUDY DESIGN

The study design was a single-blind, randomized clinical trial.

SETTING

The study was conducted at a tertiary care referral center.

PATIENTS

One hundred fifty-four patients aged 6 months to 14 years undergoing tympanostomy tube insertion participated.

INTERVENTION

For each subject, one ear was randomly assigned to receive topical ciprofloxacin, placed in the middle and external ear after surgery, while the contralateral ear served as a control.

MAIN OUTCOME MEASURE

Posttympanostomy otorrhea occurring during the period from 24 hours after surgery until 2 weeks after surgery was measured.

RESULTS

Topical ciprofloxacin application after tympanostomy tube insertion was associated with a significantly lower incidence of early posttympanostomy otorrhea. The rates of otorrhea for control and treatment ears were 9.1% and 3.9%, respectively (p = 0.029).

CONCLUSIONS

The topical administration of a single dose of ciprofloxacin solution after surgery is an effective treatment for the prevention of early posttympanostomy otorrhea.

Authors+Show Affiliations

Department of Otolaryngology, Geisinger Medical Center, Danville, Pennsylvania 17822, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10431879

Citation

Zipfel, T E., et al. "The Effect of Topical Ciprofloxacin On Postoperative Otorrhea After Tympanostomy Tube Insertion." The American Journal of Otology, vol. 20, no. 4, 1999, pp. 416-20.
Zipfel TE, Wood WE, Street DF, et al. The effect of topical ciprofloxacin on postoperative otorrhea after tympanostomy tube insertion. Am J Otol. 1999;20(4):416-20.
Zipfel, T. E., Wood, W. E., Street, D. F., Wulffman, J., Tipirneni, A., Frey, C., & Gibson, W. S. (1999). The effect of topical ciprofloxacin on postoperative otorrhea after tympanostomy tube insertion. The American Journal of Otology, 20(4), pp. 416-20.
Zipfel TE, et al. The Effect of Topical Ciprofloxacin On Postoperative Otorrhea After Tympanostomy Tube Insertion. Am J Otol. 1999;20(4):416-20. PubMed PMID: 10431879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of topical ciprofloxacin on postoperative otorrhea after tympanostomy tube insertion. AU - Zipfel,T E, AU - Wood,W E, AU - Street,D F, AU - Wulffman,J, AU - Tipirneni,A, AU - Frey,C, AU - Gibson,W S, PY - 1999/8/4/pubmed PY - 1999/8/4/medline PY - 1999/8/4/entrez SP - 416 EP - 20 JF - The American journal of otology JO - Am J Otol VL - 20 IS - 4 N2 - OBJECTIVE: This study aimed to evaluate the effectiveness of prophylactic ciprofloxacin drops in decreasing the incidence of otorrhea after tympanostomy tube insertion. STUDY DESIGN: The study design was a single-blind, randomized clinical trial. SETTING: The study was conducted at a tertiary care referral center. PATIENTS: One hundred fifty-four patients aged 6 months to 14 years undergoing tympanostomy tube insertion participated. INTERVENTION: For each subject, one ear was randomly assigned to receive topical ciprofloxacin, placed in the middle and external ear after surgery, while the contralateral ear served as a control. MAIN OUTCOME MEASURE: Posttympanostomy otorrhea occurring during the period from 24 hours after surgery until 2 weeks after surgery was measured. RESULTS: Topical ciprofloxacin application after tympanostomy tube insertion was associated with a significantly lower incidence of early posttympanostomy otorrhea. The rates of otorrhea for control and treatment ears were 9.1% and 3.9%, respectively (p = 0.029). CONCLUSIONS: The topical administration of a single dose of ciprofloxacin solution after surgery is an effective treatment for the prevention of early posttympanostomy otorrhea. SN - 0192-9763 UR - https://www.unboundmedicine.com/medline/citation/10431879/The_effect_of_topical_ciprofloxacin_on_postoperative_otorrhea_after_tympanostomy_tube_insertion_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10431879.ui DB - PRIME DP - Unbound Medicine ER -