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Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice.
J Ethnopharmacol. 1999 Jul; 66(1):113-7.JE

Abstract

The anti-inflammatory activity of the aqueous extract of the stem bark of Bridelia ferruginea was evaluated using carrageenan-induced paw oedema in rats and mice, and the cotton pellet granuloma method. The extract at doses ranging from 10 to 80 mg/kg p.o. significantly inhibited the carrageenan-induced rat paw oedema, with an ID50 value of 36 mg/kg. However, a low activity was produced in the mouse paw oedema. The extract also suppressed the granulomatous tissue formation of chronic inflammation. B. ferruginea therefore proved to be effective in both the acute and chronic phases of the inflammatory process.

Authors+Show Affiliations

Olajide OA
Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Nigeria.
Makinde JM
No affiliation info available
Awe SO
No affiliation info available

MeSH

AnimalsAnti-Inflammatory Agents, Non-SteroidalCarrageenanEdemaEuphorbiaceaeGranulomaMaleMicePlant ExtractsRatsRats, WistarWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10432217

Citation

Olajide, O A., et al. "Effects of the Aqueous Extract of Bridelia Ferruginea Stem Bark On Carrageenan-induced Oedema and Granuloma Tissue Formation in Rats and Mice." Journal of Ethnopharmacology, vol. 66, no. 1, 1999, pp. 113-7.
Olajide OA, Makinde JM, Awe SO. Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. J Ethnopharmacol. 1999;66(1):113-7.
Olajide, O. A., Makinde, J. M., & Awe, S. O. (1999). Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. Journal of Ethnopharmacology, 66(1), 113-7.
Olajide OA, Makinde JM, Awe SO. Effects of the Aqueous Extract of Bridelia Ferruginea Stem Bark On Carrageenan-induced Oedema and Granuloma Tissue Formation in Rats and Mice. J Ethnopharmacol. 1999;66(1):113-7. PubMed PMID: 10432217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. AU - Olajide,O A, AU - Makinde,J M, AU - Awe,S O, PY - 1999/8/4/pubmed PY - 1999/8/4/medline PY - 1999/8/4/entrez SP - 113 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 66 IS - 1 N2 - The anti-inflammatory activity of the aqueous extract of the stem bark of Bridelia ferruginea was evaluated using carrageenan-induced paw oedema in rats and mice, and the cotton pellet granuloma method. The extract at doses ranging from 10 to 80 mg/kg p.o. significantly inhibited the carrageenan-induced rat paw oedema, with an ID50 value of 36 mg/kg. However, a low activity was produced in the mouse paw oedema. The extract also suppressed the granulomatous tissue formation of chronic inflammation. B. ferruginea therefore proved to be effective in both the acute and chronic phases of the inflammatory process. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/10432217/Effects_of_the_aqueous_extract_of_Bridelia_ferruginea_stem_bark_on_carrageenan_induced_oedema_and_granuloma_tissue_formation_in_rats_and_mice_ DB - PRIME DP - Unbound Medicine ER -