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Reliability of breath-alcohol analysis in individuals with gastroesophageal reflux disease.
J Forensic Sci 1999; 44(4):814-8JF

Abstract

Gastroesophageal reflux disease (GERD) is widespread in the population among all age groups and in both sexes. The reliability of breath alcohol analysis in subjects suffering from GERD is unknown. We investigated the relationship between breath-alcohol concentration (BrAC) and blood-alcohol concentration (BAC) in 5 male and 5 female subjects all suffering from severe gastroesophageal reflux disease and scheduled for antireflux surgery. Each subject served in two experiments in random order about 1-2 weeks apart. Both times they drank the same dose of ethanol (approximately 0.3 g/kg) as either beer, white wine, or vodka mixed with orange juice before venous blood and end-expired breath samples were obtained at 5-10 min intervals for 4 h. An attempt was made to provoke gastroesophageal reflux in one of the drinking experiments by applying an abdominal compression belt. Blood-ethanol concentration was determined by headspace gas chromatography and breath-ethanol was measured with an electrochemical instrument (Alcolmeter SD-400) or a quantitative infrared analyzer (Data-Master). During the absorption of alcohol, which occurred during the first 90 min after the start of drinking, BrAC (mg/210 L) tended to be the same or higher than venous BAC (mg/dL). In the post-peak phase, the BAC always exceeded BrAC. Four of the 10 subjects definitely experienced gastric reflux during the study although this did not result in widely deviant BrAC readings compared with BAC when sampling occurred at 5-min intervals. We conclude that the risk of alcohol erupting from the stomach into the mouth owing to gastric reflux and falsely increasing the result of an evidential breath-alcohol test is highly improbable.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, University Hospital, Linköping, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10432616

Citation

Kechagias, S, et al. "Reliability of Breath-alcohol Analysis in Individuals With Gastroesophageal Reflux Disease." Journal of Forensic Sciences, vol. 44, no. 4, 1999, pp. 814-8.
Kechagias S, Jönsson KA, Franzén T, et al. Reliability of breath-alcohol analysis in individuals with gastroesophageal reflux disease. J Forensic Sci. 1999;44(4):814-8.
Kechagias, S., Jönsson, K. A., Franzén, T., Andersson, L., & Jones, A. W. (1999). Reliability of breath-alcohol analysis in individuals with gastroesophageal reflux disease. Journal of Forensic Sciences, 44(4), pp. 814-8.
Kechagias S, et al. Reliability of Breath-alcohol Analysis in Individuals With Gastroesophageal Reflux Disease. J Forensic Sci. 1999;44(4):814-8. PubMed PMID: 10432616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reliability of breath-alcohol analysis in individuals with gastroesophageal reflux disease. AU - Kechagias,S, AU - Jönsson,K A, AU - Franzén,T, AU - Andersson,L, AU - Jones,A W, PY - 1999/8/5/pubmed PY - 1999/8/5/medline PY - 1999/8/5/entrez SP - 814 EP - 8 JF - Journal of forensic sciences JO - J. Forensic Sci. VL - 44 IS - 4 N2 - Gastroesophageal reflux disease (GERD) is widespread in the population among all age groups and in both sexes. The reliability of breath alcohol analysis in subjects suffering from GERD is unknown. We investigated the relationship between breath-alcohol concentration (BrAC) and blood-alcohol concentration (BAC) in 5 male and 5 female subjects all suffering from severe gastroesophageal reflux disease and scheduled for antireflux surgery. Each subject served in two experiments in random order about 1-2 weeks apart. Both times they drank the same dose of ethanol (approximately 0.3 g/kg) as either beer, white wine, or vodka mixed with orange juice before venous blood and end-expired breath samples were obtained at 5-10 min intervals for 4 h. An attempt was made to provoke gastroesophageal reflux in one of the drinking experiments by applying an abdominal compression belt. Blood-ethanol concentration was determined by headspace gas chromatography and breath-ethanol was measured with an electrochemical instrument (Alcolmeter SD-400) or a quantitative infrared analyzer (Data-Master). During the absorption of alcohol, which occurred during the first 90 min after the start of drinking, BrAC (mg/210 L) tended to be the same or higher than venous BAC (mg/dL). In the post-peak phase, the BAC always exceeded BrAC. Four of the 10 subjects definitely experienced gastric reflux during the study although this did not result in widely deviant BrAC readings compared with BAC when sampling occurred at 5-min intervals. We conclude that the risk of alcohol erupting from the stomach into the mouth owing to gastric reflux and falsely increasing the result of an evidential breath-alcohol test is highly improbable. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/10432616/Reliability_of_breath_alcohol_analysis_in_individuals_with_gastroesophageal_reflux_disease_ L2 - http://www.diseaseinfosearch.org/result/2996 DB - PRIME DP - Unbound Medicine ER -