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CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement.
Intern Med. 1999 Jul; 38(7):547-55.IM

Abstract

OBJECT

We describe the characteristics of three patients with CD56+CD7+ stem cell leukemia/lymphoma.

METHODS

These blasts were analyzed for morphologic, karyotypic, immunophenotypic, and immunogenotypic features using Southern blot and polymerase chain reaction analysis.

MATERIALS

Peripheral blood, bone marrow aspirates, or biopsied mediastinal tumor specimens of three CD56+CD7+ stem cell leukemia/lymphoma patients were investigated.

RESULTS

The bone marrow of all patients showed myeloperoxidase (MPO) negative blast cells with basophilic cytoplasm and distinct nucleoli with no azurophilic granules. The blasts of two patients were classified as acute lymphoblastic leukemia (L2). The liver, spleen, and lymph nodes were unaffected in all patients. All had an aggressive clinical course. The blasts were strongly positive for both CD7 and CD56 but negative for other T-lineage associated antigens, including CD1, CD2, surface membrane CD3, cytoplasmic CD3c (2/2), CD4, CD5 and CD8. The additional antigens were recognized as follows: CD19 (1/3 cases) as a B lineage, CD33 (1/3) as a myeloid marker, CD34 (2/3) as a stem cell, CD38 (1/1) and HLA-DR (2/3). When the patients relapsed, the phenotypes changed to blasts positive for CD5, CD10 and CD13 in patient 1, CD5 in patient 2, and CD33 in patient 3. MPO, however, remained negative. Cytogenetic analysis showed no common abnormal karyotype. All had a common D2-Jdelta1 induced by T-cell specific enhancer. Rearrangement of TCR beta and gamma genes occurred in patient 2, and IgH and TCR beta underwent rearrangement in patient 3.

CONCLUSION

Although a more comprehensive case analysis is necessary, these data suggest the possibility that the blasts of the present cases come from a common lymphoid precursor (T, NK, and B cell) or from a NKT precursor as the fourth lymphoid lineage.

Authors+Show Affiliations

First Department of Internal Medicine, Fukuoka University School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10435360

Citation

Yoshida, T, et al. "CD56+CD7+ Stem Cell Leukemia/lymphoma With D2-Jdelta1 Rearrangement." Internal Medicine (Tokyo, Japan), vol. 38, no. 7, 1999, pp. 547-55.
Yoshida T, Kimura N, Sawada H, et al. CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. Intern Med. 1999;38(7):547-55.
Yoshida, T., Kimura, N., Sawada, H., Suematsu, E., Nagano, M., Akiyoshi, T., Motomura, S., Kikuchi, M., Nishimura, J., & Tamura, K. (1999). CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. Internal Medicine (Tokyo, Japan), 38(7), 547-55.
Yoshida T, et al. CD56+CD7+ Stem Cell Leukemia/lymphoma With D2-Jdelta1 Rearrangement. Intern Med. 1999;38(7):547-55. PubMed PMID: 10435360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD56+CD7+ stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement. AU - Yoshida,T, AU - Kimura,N, AU - Sawada,H, AU - Suematsu,E, AU - Nagano,M, AU - Akiyoshi,T, AU - Motomura,S, AU - Kikuchi,M, AU - Nishimura,J, AU - Tamura,K, PY - 1999/8/6/pubmed PY - 1999/8/6/medline PY - 1999/8/6/entrez SP - 547 EP - 55 JF - Internal medicine (Tokyo, Japan) JO - Intern Med VL - 38 IS - 7 N2 - OBJECT: We describe the characteristics of three patients with CD56+CD7+ stem cell leukemia/lymphoma. METHODS: These blasts were analyzed for morphologic, karyotypic, immunophenotypic, and immunogenotypic features using Southern blot and polymerase chain reaction analysis. MATERIALS: Peripheral blood, bone marrow aspirates, or biopsied mediastinal tumor specimens of three CD56+CD7+ stem cell leukemia/lymphoma patients were investigated. RESULTS: The bone marrow of all patients showed myeloperoxidase (MPO) negative blast cells with basophilic cytoplasm and distinct nucleoli with no azurophilic granules. The blasts of two patients were classified as acute lymphoblastic leukemia (L2). The liver, spleen, and lymph nodes were unaffected in all patients. All had an aggressive clinical course. The blasts were strongly positive for both CD7 and CD56 but negative for other T-lineage associated antigens, including CD1, CD2, surface membrane CD3, cytoplasmic CD3c (2/2), CD4, CD5 and CD8. The additional antigens were recognized as follows: CD19 (1/3 cases) as a B lineage, CD33 (1/3) as a myeloid marker, CD34 (2/3) as a stem cell, CD38 (1/1) and HLA-DR (2/3). When the patients relapsed, the phenotypes changed to blasts positive for CD5, CD10 and CD13 in patient 1, CD5 in patient 2, and CD33 in patient 3. MPO, however, remained negative. Cytogenetic analysis showed no common abnormal karyotype. All had a common D2-Jdelta1 induced by T-cell specific enhancer. Rearrangement of TCR beta and gamma genes occurred in patient 2, and IgH and TCR beta underwent rearrangement in patient 3. CONCLUSION: Although a more comprehensive case analysis is necessary, these data suggest the possibility that the blasts of the present cases come from a common lymphoid precursor (T, NK, and B cell) or from a NKT precursor as the fourth lymphoid lineage. SN - 0918-2918 UR - https://www.unboundmedicine.com/medline/citation/10435360/CD56+CD7+_stem_cell_leukemia/lymphoma_with_D2_Jdelta1_rearrangement_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/38.547?from=PubMed DB - PRIME DP - Unbound Medicine ER -