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Glomerular filtration rate estimated from the uptake phase of 99mTc-DTPA renography in chronic renal failure.
Nephrol Dial Transplant. 1999 Jul; 14(7):1673-8.ND

Abstract

BACKGROUND

The purpose of the study was to compare the estimation of glomerular filtration rate (GFR) from 99mTc-DTPA renography with that estimated from the renal clearance of 51Cr-EDTA, creatinine and urea.

METHODS

Fifty patients with reduced renal function (serum creatinine between 150 and 600 micromol/l) were enrolled in the study. GFR was estimated from the uptake phase of 99mTc-DTPA renography (GFR(DTPA)). The renal clearance of 51Cr-EDTA (GFR(EDTA)) was used as the reference method. Creatinine clearance (C(Cr)), urea clearance (C(Ur)) and the mean of urea and creatinine clearance (C(Cr+Ur)/2) were also calculated from urine collected during a period of 24 h. Limits of agreement were used for method comparison.

RESULTS

The limit of agreement between GFR(DTPA) and GFR(EDTA) was 2 +/- 17 ml/min. The mean difference did not deviate significantly from zero. The other clearance techniques had larger limits of agreement and a mean difference significantly different from zero. Furthermore, C(Ur) and C(Cr+Ur)/2 had systematic deviations of the differences, indicating that C(Ur) and C(Cr+Ur)/2 are poor estimates of GFR.

CONCLUSION

The limit of agreement between GFR(DTPA) and GFR(EDTA) are acceptable and, therefore, GFR estimated from 99mTc-DTPA renography is acceptable for clinical use in patients with reduced renal function. Furthermore, the method is simple and less time consuming compared with renal clearance techniques.

Authors+Show Affiliations

Department of Nephrology, Hvidovre Hospital, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10435875

Citation

Petersen, L J., et al. "Glomerular Filtration Rate Estimated From the Uptake Phase of 99mTc-DTPA Renography in Chronic Renal Failure." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 14, no. 7, 1999, pp. 1673-8.
Petersen LJ, Petersen JR, Talleruphuus U, et al. Glomerular filtration rate estimated from the uptake phase of 99mTc-DTPA renography in chronic renal failure. Nephrol Dial Transplant. 1999;14(7):1673-8.
Petersen, L. J., Petersen, J. R., Talleruphuus, U., Møller, M. L., Ladefoged, S. D., Mehlsen, J., & Jensen, H. A. (1999). Glomerular filtration rate estimated from the uptake phase of 99mTc-DTPA renography in chronic renal failure. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 14(7), 1673-8.
Petersen LJ, et al. Glomerular Filtration Rate Estimated From the Uptake Phase of 99mTc-DTPA Renography in Chronic Renal Failure. Nephrol Dial Transplant. 1999;14(7):1673-8. PubMed PMID: 10435875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glomerular filtration rate estimated from the uptake phase of 99mTc-DTPA renography in chronic renal failure. AU - Petersen,L J, AU - Petersen,J R, AU - Talleruphuus,U, AU - Møller,M L, AU - Ladefoged,S D, AU - Mehlsen,J, AU - Jensen,H A, PY - 1999/8/6/pubmed PY - 1999/8/6/medline PY - 1999/8/6/entrez SP - 1673 EP - 8 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 14 IS - 7 N2 - BACKGROUND: The purpose of the study was to compare the estimation of glomerular filtration rate (GFR) from 99mTc-DTPA renography with that estimated from the renal clearance of 51Cr-EDTA, creatinine and urea. METHODS: Fifty patients with reduced renal function (serum creatinine between 150 and 600 micromol/l) were enrolled in the study. GFR was estimated from the uptake phase of 99mTc-DTPA renography (GFR(DTPA)). The renal clearance of 51Cr-EDTA (GFR(EDTA)) was used as the reference method. Creatinine clearance (C(Cr)), urea clearance (C(Ur)) and the mean of urea and creatinine clearance (C(Cr+Ur)/2) were also calculated from urine collected during a period of 24 h. Limits of agreement were used for method comparison. RESULTS: The limit of agreement between GFR(DTPA) and GFR(EDTA) was 2 +/- 17 ml/min. The mean difference did not deviate significantly from zero. The other clearance techniques had larger limits of agreement and a mean difference significantly different from zero. Furthermore, C(Ur) and C(Cr+Ur)/2 had systematic deviations of the differences, indicating that C(Ur) and C(Cr+Ur)/2 are poor estimates of GFR. CONCLUSION: The limit of agreement between GFR(DTPA) and GFR(EDTA) are acceptable and, therefore, GFR estimated from 99mTc-DTPA renography is acceptable for clinical use in patients with reduced renal function. Furthermore, the method is simple and less time consuming compared with renal clearance techniques. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/10435875/Glomerular_filtration_rate_estimated_from_the_uptake_phase_of_99mTc_DTPA_renography_in_chronic_renal_failure_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/14.7.1673 DB - PRIME DP - Unbound Medicine ER -