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Suppression of oxygen toxicity by melatonin.
Zhongguo Yao Li Xue Bao. 1998 Nov; 19(6):575-81.ZY

Abstract

Melatonin, the chief secretory product of the pineal gland, was recently found to be a free radical scavenger and antioxidant. While most studies to date have used pharmacological quantities of melatonin to limit oxidative damage, physiologic concentrations of the indole which are present in aerobic organisms have also been shown to resist molecular damage inflicted by free radicals. Melatonin has several functions in terms of its antioxidative ability. It readily scavenges the most highly toxic free radical, the hydroxyl radical, and it directly detoxifies the peroxynitrite anion, nitric oxide, singlet oxygen, and the peroxyl radical. Precisely how efficient melatonin is in neutralizing each of these toxic agents remains to be determined. Melatonin also may stimulate several antioxidative enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase as well as inhibiting the pro-oxidative enzyme, nitric-oxide synthase. Finally, melatonin chelates transition metal ions and prevents the deterioration of cellular membranes. This combination of actions may all contribute to melatonin's ability to reduce oxidative damage. Melatonin is highly effective in reducing nuclear DNA damage and membrane lipid destruction due to toxic free radicals in vivo. These findings have implications for disease processes, eg, neurodegenerative and cardiovascular diseases, which involve free radicals and for aging itself, which also is believed to be related to accumulated oxidative damage.

Authors+Show Affiliations

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762, USA. Reiter@uthscsa.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10437151

Citation

Reiter, R J., et al. "Suppression of Oxygen Toxicity By Melatonin." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 19, no. 6, 1998, pp. 575-81.
Reiter RJ, Tan DX, Qi WB. Suppression of oxygen toxicity by melatonin. Zhongguo Yao Li Xue Bao. 1998;19(6):575-81.
Reiter, R. J., Tan, D. X., & Qi, W. B. (1998). Suppression of oxygen toxicity by melatonin. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 19(6), 575-81.
Reiter RJ, Tan DX, Qi WB. Suppression of Oxygen Toxicity By Melatonin. Zhongguo Yao Li Xue Bao. 1998;19(6):575-81. PubMed PMID: 10437151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of oxygen toxicity by melatonin. AU - Reiter,R J, AU - Tan,D X, AU - Qi,W B, PY - 1999/8/7/pubmed PY - 1999/8/7/medline PY - 1999/8/7/entrez SP - 575 EP - 81 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 19 IS - 6 N2 - Melatonin, the chief secretory product of the pineal gland, was recently found to be a free radical scavenger and antioxidant. While most studies to date have used pharmacological quantities of melatonin to limit oxidative damage, physiologic concentrations of the indole which are present in aerobic organisms have also been shown to resist molecular damage inflicted by free radicals. Melatonin has several functions in terms of its antioxidative ability. It readily scavenges the most highly toxic free radical, the hydroxyl radical, and it directly detoxifies the peroxynitrite anion, nitric oxide, singlet oxygen, and the peroxyl radical. Precisely how efficient melatonin is in neutralizing each of these toxic agents remains to be determined. Melatonin also may stimulate several antioxidative enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase as well as inhibiting the pro-oxidative enzyme, nitric-oxide synthase. Finally, melatonin chelates transition metal ions and prevents the deterioration of cellular membranes. This combination of actions may all contribute to melatonin's ability to reduce oxidative damage. Melatonin is highly effective in reducing nuclear DNA damage and membrane lipid destruction due to toxic free radicals in vivo. These findings have implications for disease processes, eg, neurodegenerative and cardiovascular diseases, which involve free radicals and for aging itself, which also is believed to be related to accumulated oxidative damage. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/10437151/Suppression_of_oxygen_toxicity_by_melatonin_ L2 - http://www.chinaphar.com/1671-4083/19/575.pdf DB - PRIME DP - Unbound Medicine ER -