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[Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno-2 study].
Ugeskr Laeger 1999; 161(30):4277-85UL

Abstract

We carried out a randomized trial of stepwise intensive treatment or standard treatment of risk factors in patients with type 2 diabetes and microalbuminuria. Patients were allocated standard treatment (n = 80) or intensive treatment (n = 80). Intensive treatment was a stepwise implementation of behaviour modification, pharmacological therapy targeting hyperglycaemia, hypertension, dyslipidaemia, and microalbuminuria. The primary endpoint was development of nephropathy. Secondary endpoints were incidence or progression of diabetic retinopathy and neuropathy. Patients were followed for 3.8 years. The intensive group had significantly lower rates of progression to hephropathy (odds ratio 0.27 [95% CI 0.10-0.75]), progression of retinopathy (0.45 (0.21-0.95]), and progression of autonomic neuropathy (0.32 [0.12-0.78]). In conclusion, intensified multifactorial intervention in patients with type 2 diabetic mellitus and microalbuminuria has beneficial effects on long-term complications.

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

dan

PubMed ID

10439688

Citation

Gaede, P H., et al. "[Intensified Multifactorial Intervention in Patients With Type 2 Diabetes Mellitus and Microalbuminuria: the Steno-2 Study]." Ugeskrift for Laeger, vol. 161, no. 30, 1999, pp. 4277-85.
Gaede PH, Jepsen PV, Parving HH, et al. [Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno-2 study]. Ugeskr Laeg. 1999;161(30):4277-85.
Gaede, P. H., Jepsen, P. V., Parving, H. H., & Pedersen, O. B. (1999). [Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno-2 study]. Ugeskrift for Laeger, 161(30), pp. 4277-85.
Gaede PH, et al. [Intensified Multifactorial Intervention in Patients With Type 2 Diabetes Mellitus and Microalbuminuria: the Steno-2 Study]. Ugeskr Laeg. 1999 Jul 26;161(30):4277-85. PubMed PMID: 10439688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno-2 study]. AU - Gaede,P H, AU - Jepsen,P V, AU - Parving,H H, AU - Pedersen,O B, PY - 1999/8/10/pubmed PY - 1999/8/10/medline PY - 1999/8/10/entrez SP - 4277 EP - 85 JF - Ugeskrift for laeger JO - Ugeskr. Laeg. VL - 161 IS - 30 N2 - We carried out a randomized trial of stepwise intensive treatment or standard treatment of risk factors in patients with type 2 diabetes and microalbuminuria. Patients were allocated standard treatment (n = 80) or intensive treatment (n = 80). Intensive treatment was a stepwise implementation of behaviour modification, pharmacological therapy targeting hyperglycaemia, hypertension, dyslipidaemia, and microalbuminuria. The primary endpoint was development of nephropathy. Secondary endpoints were incidence or progression of diabetic retinopathy and neuropathy. Patients were followed for 3.8 years. The intensive group had significantly lower rates of progression to hephropathy (odds ratio 0.27 [95% CI 0.10-0.75]), progression of retinopathy (0.45 (0.21-0.95]), and progression of autonomic neuropathy (0.32 [0.12-0.78]). In conclusion, intensified multifactorial intervention in patients with type 2 diabetic mellitus and microalbuminuria has beneficial effects on long-term complications. SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/10439688/[Intensified_multifactorial_intervention_in_patients_with_type_2_diabetes_mellitus_and_microalbuminuria:_the_Steno_2_study]_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -