Tags

Type your tag names separated by a space and hit enter

Profiles of GBV-C/hepatitis G virus markers in patients coinfected with hepatitis C virus.
J Med Virol. 1999 Sep; 59(1):45-51.JM

Abstract

GBV-C/Hepatitis G virus (GBV-C/HGV) is a newly discovered viral agent, found widely among healthy blood donors and among individuals at risk of parenterally transmitted infections. GBV-C/HGV is found frequently in coinfection with HCV. A population of 109 HCV positive patients was examined for the presence of GBV-C/HGV RNA and antibodies to E2. Of the 109 patients, 23 (21%) had serum GBV-C/HGV RNA in serum, 39 (36%) had only antibodies to E2 and 8 (7%) were positive for both markers, with an overall prevalence of 64%. Different serologic and virological patterns were observed in GBV-C/HGV exposed patients according to their infection status. Active infection was characterized by positive RT/PCR signal with primers for both the 5'UTR and NS5 genomic regions, viremia levels above 10(4) copies/mL by real time quantitative RT/PCR and absence of detectable anti-E2. In the transition phase between active infection and recovery, GBV-C/HGV RNA was only detectable by RT/PCR using primers from the 5' untranslated region and viremia levels were below 10(4) copies/ml by quantitative PCR, with or without simultaneous presence of anti-E2 antibodies. Resolved infection was characterized by absence of detectable viremia and, in most patients, by the presence of anti-E2.

Authors+Show Affiliations

Liver Unit, Hospital General Universitari Vall d'Hebron, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10440807

Citation

Sauleda, S, et al. "Profiles of GBV-C/hepatitis G Virus Markers in Patients Coinfected With Hepatitis C Virus." Journal of Medical Virology, vol. 59, no. 1, 1999, pp. 45-51.
Sauleda S, Reesink HJ, Esteban JI, et al. Profiles of GBV-C/hepatitis G virus markers in patients coinfected with hepatitis C virus. J Med Virol. 1999;59(1):45-51.
Sauleda, S., Reesink, H. J., Esteban, J. I., Hess, G., Esteban, R., & Guardia, J. (1999). Profiles of GBV-C/hepatitis G virus markers in patients coinfected with hepatitis C virus. Journal of Medical Virology, 59(1), 45-51.
Sauleda S, et al. Profiles of GBV-C/hepatitis G Virus Markers in Patients Coinfected With Hepatitis C Virus. J Med Virol. 1999;59(1):45-51. PubMed PMID: 10440807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Profiles of GBV-C/hepatitis G virus markers in patients coinfected with hepatitis C virus. AU - Sauleda,S, AU - Reesink,H J, AU - Esteban,J I, AU - Hess,G, AU - Esteban,R, AU - Guardia,J, PY - 1999/8/10/pubmed PY - 1999/8/10/medline PY - 1999/8/10/entrez SP - 45 EP - 51 JF - Journal of medical virology JO - J Med Virol VL - 59 IS - 1 N2 - GBV-C/Hepatitis G virus (GBV-C/HGV) is a newly discovered viral agent, found widely among healthy blood donors and among individuals at risk of parenterally transmitted infections. GBV-C/HGV is found frequently in coinfection with HCV. A population of 109 HCV positive patients was examined for the presence of GBV-C/HGV RNA and antibodies to E2. Of the 109 patients, 23 (21%) had serum GBV-C/HGV RNA in serum, 39 (36%) had only antibodies to E2 and 8 (7%) were positive for both markers, with an overall prevalence of 64%. Different serologic and virological patterns were observed in GBV-C/HGV exposed patients according to their infection status. Active infection was characterized by positive RT/PCR signal with primers for both the 5'UTR and NS5 genomic regions, viremia levels above 10(4) copies/mL by real time quantitative RT/PCR and absence of detectable anti-E2. In the transition phase between active infection and recovery, GBV-C/HGV RNA was only detectable by RT/PCR using primers from the 5' untranslated region and viremia levels were below 10(4) copies/ml by quantitative PCR, with or without simultaneous presence of anti-E2 antibodies. Resolved infection was characterized by absence of detectable viremia and, in most patients, by the presence of anti-E2. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/10440807/Profiles_of_GBV_C/hepatitis_G_virus_markers_in_patients_coinfected_with_hepatitis_C_virus_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0146-6615&date=1999&volume=59&issue=1&spage=45 DB - PRIME DP - Unbound Medicine ER -