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Vitamin B6 in treatment of tardive dyskinesia: a preliminary case series study.
Clin Neuropharmacol. 1999 Jul-Aug; 22(4):241-3.CN

Abstract

Tardive dyskinesia (TD) remains a significant problem for patients and physicians. Several reports have suggested that vitamin B6 (pyridoxine) can be helpful in the treatment of some neuroleptic-induced movement disorders, including parkinsonism and TD. This report presents the results of a preliminary study of five patients with TD who underwent a four week open-label clinical trial of vitamin B6 (100 mg/d) in addition to their regular medications. The severity of the involuntary movements was assessed using the Abnormal Involuntary Movement Scale (AIMS), Barnes Akathisia Rating Scale (BARS) and the Simpson-Angus Scale (SAS). The patients' clinical status was assessed with the Brief Psychiatric Rating Scale (BPRS). With the addition of vitamin B6 to their treatment, four patients had clinically significant (greater than 30%) improvement on the measures of involuntary movement and, in three cases, there was also clinically significant improvement on the BPRS. None of the patients had side effects attributable to vitamin B6. The results suggest that vitamin B6 may alleviate TD, but it will need to be further tested in controlled double-blind trials.

Authors+Show Affiliations

Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10442256

Citation

Lerner, V, et al. "Vitamin B6 in Treatment of Tardive Dyskinesia: a Preliminary Case Series Study." Clinical Neuropharmacology, vol. 22, no. 4, 1999, pp. 241-3.
Lerner V, Kaptsan A, Miodownik C, et al. Vitamin B6 in treatment of tardive dyskinesia: a preliminary case series study. Clin Neuropharmacol. 1999;22(4):241-3.
Lerner, V., Kaptsan, A., Miodownik, C., & Kotler, M. (1999). Vitamin B6 in treatment of tardive dyskinesia: a preliminary case series study. Clinical Neuropharmacology, 22(4), 241-3.
Lerner V, et al. Vitamin B6 in Treatment of Tardive Dyskinesia: a Preliminary Case Series Study. Clin Neuropharmacol. 1999;22(4):241-3. PubMed PMID: 10442256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin B6 in treatment of tardive dyskinesia: a preliminary case series study. AU - Lerner,V, AU - Kaptsan,A, AU - Miodownik,C, AU - Kotler,M, PY - 1999/8/12/pubmed PY - 1999/8/12/medline PY - 1999/8/12/entrez SP - 241 EP - 3 JF - Clinical neuropharmacology JO - Clin Neuropharmacol VL - 22 IS - 4 N2 - Tardive dyskinesia (TD) remains a significant problem for patients and physicians. Several reports have suggested that vitamin B6 (pyridoxine) can be helpful in the treatment of some neuroleptic-induced movement disorders, including parkinsonism and TD. This report presents the results of a preliminary study of five patients with TD who underwent a four week open-label clinical trial of vitamin B6 (100 mg/d) in addition to their regular medications. The severity of the involuntary movements was assessed using the Abnormal Involuntary Movement Scale (AIMS), Barnes Akathisia Rating Scale (BARS) and the Simpson-Angus Scale (SAS). The patients' clinical status was assessed with the Brief Psychiatric Rating Scale (BPRS). With the addition of vitamin B6 to their treatment, four patients had clinically significant (greater than 30%) improvement on the measures of involuntary movement and, in three cases, there was also clinically significant improvement on the BPRS. None of the patients had side effects attributable to vitamin B6. The results suggest that vitamin B6 may alleviate TD, but it will need to be further tested in controlled double-blind trials. SN - 0362-5664 UR - https://www.unboundmedicine.com/medline/citation/10442256/Vitamin_B6_in_treatment_of_tardive_dyskinesia:_a_preliminary_case_series_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10442256.ui DB - PRIME DP - Unbound Medicine ER -