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Lichen sclerosus of the vulva. Long-term steroid maintenance therapy.
J Reprod Med. 1999 Jul; 44(7):621-4.JR

Abstract

OBJECTIVE

To assess the efficacy of graduated topical steroids for long-term maintenance therapy for vulvar lichen sclerosus.

STUDY DESIGN

A prospective observational study was performed in the Gynaecological Oncology Department, City Hospital, Birmingham, U.K. Fifty-four patients were recruited for the study. The diagnosis was confirmed with histopathologic examination. After confirmation of the diagnosis, patients were started on a diminishing regimen of topical steroid.

RESULTS

Of the 54 patients in the study, 51 responded to the steroid regimen, and three did not.

CONCLUSION

The graduated topical steroid regimen has a high response rate and takes a relatively short time to achieve, justifying the use of graduated topical steroids for this condition. Graduated dose reduction allows the majority of patients to remain in asymptomatic remission and minimize steroid exposure.

Authors+Show Affiliations

Sinha P
City Hospital, Birmingham, U.K.
Sorinola O
No affiliation info available
Luesley DM
No affiliation info available

MeSH

Administration, CutaneousAdultAnti-Inflammatory AgentsBetamethasoneClobetasolDrug Administration ScheduleFemaleFollow-Up StudiesGlucocorticoidsHumansLichen Sclerosus et AtrophicusMiddle AgedProspective StudiesTreatment OutcomeVulvar Diseases

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10442326

Citation

Sinha, P, et al. "Lichen Sclerosus of the Vulva. Long-term Steroid Maintenance Therapy." The Journal of Reproductive Medicine, vol. 44, no. 7, 1999, pp. 621-4.
Sinha P, Sorinola O, Luesley DM. Lichen sclerosus of the vulva. Long-term steroid maintenance therapy. J Reprod Med. 1999;44(7):621-4.
Sinha, P., Sorinola, O., & Luesley, D. M. (1999). Lichen sclerosus of the vulva. Long-term steroid maintenance therapy. The Journal of Reproductive Medicine, 44(7), 621-4.
Sinha P, Sorinola O, Luesley DM. Lichen Sclerosus of the Vulva. Long-term Steroid Maintenance Therapy. J Reprod Med. 1999;44(7):621-4. PubMed PMID: 10442326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lichen sclerosus of the vulva. Long-term steroid maintenance therapy. AU - Sinha,P, AU - Sorinola,O, AU - Luesley,D M, PY - 1999/8/12/pubmed PY - 2000/3/18/medline PY - 1999/8/12/entrez SP - 621 EP - 4 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 44 IS - 7 N2 - OBJECTIVE: To assess the efficacy of graduated topical steroids for long-term maintenance therapy for vulvar lichen sclerosus. STUDY DESIGN: A prospective observational study was performed in the Gynaecological Oncology Department, City Hospital, Birmingham, U.K. Fifty-four patients were recruited for the study. The diagnosis was confirmed with histopathologic examination. After confirmation of the diagnosis, patients were started on a diminishing regimen of topical steroid. RESULTS: Of the 54 patients in the study, 51 responded to the steroid regimen, and three did not. CONCLUSION: The graduated topical steroid regimen has a high response rate and takes a relatively short time to achieve, justifying the use of graduated topical steroids for this condition. Graduated dose reduction allows the majority of patients to remain in asymptomatic remission and minimize steroid exposure. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/10442326/Lichen_sclerosus_of_the_vulva__Long_term_steroid_maintenance_therapy_ DB - PRIME DP - Unbound Medicine ER -