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Cytokeratins expression in paragangliomas of the cauda equina.
Clin Neuropathol. 1999 Jul-Aug; 18(4):208-13.CN

Abstract

BACKGROUND

Paragangliomas rarely involve the cauda equina region. In this location, these tumors can show misleading morphological features such as trabecular or papillary growth patterns and variable expression of cytokeratins.

METHODS

We comparatively studied the immunohistochemical and ultrastructural patterns of 3 paragangliomas of the cauda equina (PCE) and of 8 paragangliomas from other sites.

RESULTS

All the paragangliomas expressed neuroendocrine markers (neuron-specific enolase, chromogranin A, synaptophysin and neurofilament protein). In PCE, chief cells exhibited a strong positivity with a broad spectrum anti-cytokeratin antibody. The staining was diffuse in the cytoplasm or had a paranuclear dot-like disposition. In other sites, only one paraganglioma showed a focal expression of cytokeratins. At ultrastructural level, chief cells of PCE contained characteristic dense core granules and intermediate-sized filaments sometimes grouped in paranuclear whorls.

CONCLUSION

The dual immunophenotype of PCE, paraganglionic and epithelial, must be recognized in order to distinguish these tumors from, for example, a metastasis of a neuroendocrine carcinoma. PCE are slow-growing tumors and have mostly a favorable prognosis after complete surgical excision.

Authors+Show Affiliations

Department of Pathology, Dupuytren Hospital, Limoges, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10442464

Citation

Labrousse, F, et al. "Cytokeratins Expression in Paragangliomas of the Cauda Equina." Clinical Neuropathology, vol. 18, no. 4, 1999, pp. 208-13.
Labrousse F, Leboutet MJ, Petit B, et al. Cytokeratins expression in paragangliomas of the cauda equina. Clin Neuropathol. 1999;18(4):208-13.
Labrousse, F., Leboutet, M. J., Petit, B., Paraf, F., Boncoeur-Martel, M. P., Moreau, J. J., & Catanzano, G. (1999). Cytokeratins expression in paragangliomas of the cauda equina. Clinical Neuropathology, 18(4), 208-13.
Labrousse F, et al. Cytokeratins Expression in Paragangliomas of the Cauda Equina. Clin Neuropathol. 1999 Jul-Aug;18(4):208-13. PubMed PMID: 10442464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokeratins expression in paragangliomas of the cauda equina. AU - Labrousse,F, AU - Leboutet,M J, AU - Petit,B, AU - Paraf,F, AU - Boncoeur-Martel,M P, AU - Moreau,J J, AU - Catanzano,G, PY - 1999/8/12/pubmed PY - 1999/8/12/medline PY - 1999/8/12/entrez SP - 208 EP - 13 JF - Clinical neuropathology JO - Clin. Neuropathol. VL - 18 IS - 4 N2 - BACKGROUND: Paragangliomas rarely involve the cauda equina region. In this location, these tumors can show misleading morphological features such as trabecular or papillary growth patterns and variable expression of cytokeratins. METHODS: We comparatively studied the immunohistochemical and ultrastructural patterns of 3 paragangliomas of the cauda equina (PCE) and of 8 paragangliomas from other sites. RESULTS: All the paragangliomas expressed neuroendocrine markers (neuron-specific enolase, chromogranin A, synaptophysin and neurofilament protein). In PCE, chief cells exhibited a strong positivity with a broad spectrum anti-cytokeratin antibody. The staining was diffuse in the cytoplasm or had a paranuclear dot-like disposition. In other sites, only one paraganglioma showed a focal expression of cytokeratins. At ultrastructural level, chief cells of PCE contained characteristic dense core granules and intermediate-sized filaments sometimes grouped in paranuclear whorls. CONCLUSION: The dual immunophenotype of PCE, paraganglionic and epithelial, must be recognized in order to distinguish these tumors from, for example, a metastasis of a neuroendocrine carcinoma. PCE are slow-growing tumors and have mostly a favorable prognosis after complete surgical excision. SN - 0722-5091 UR - https://www.unboundmedicine.com/medline/citation/10442464/Cytokeratins_expression_in_paragangliomas_of_the_cauda_equina_ DB - PRIME DP - Unbound Medicine ER -