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Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers.
Ophthalmology 1999; 106(8):1504-10; discussion 1511O

Abstract

PURPOSE

To evaluate the efficacy of multilayer amniotic membrane transplantation for reconstruction of corneal epithelium and stroma in the context of deep corneal ulcers.

DESIGN

Prospective, noncomparative, interventional case series.

PARTICIPANTS

Eleven consecutive patients with deep corneal ulcers refractory to conventional treatment; six patients had herpetic keratitis and five had other forms of neurotrophic keratitis.

INTERVENTION

Multilayer amniotic membrane transplantation with kryopreserved human amniotic membrane.

MAIN OUTCOME MEASURES

Integrity of corneal epithelium and stroma, opacification, and appearance of grafted membrane during 12 months follow-up.

RESULTS

Amniotic membrane transplantation markedly reduced ocular inflammation in all patients. Epithelium healed above all corneal ulcers within 4 weeks and remained stable in 9 of 11 patients for 1 year. Two patients with recurrent epithelial defect suffered from severe neurotrophic keratitis. Following transplantation the amniotic membranes gradually dissolved over a period of 12 months, but stromal thickness remained stable.

CONCLUSION

Amniotic membrane transplantation allows corneal surface reconstruction in patients with persistent epithelial defects. The multilayer technique is useful for treating deep corneal ulcers and even descemetoceles. Because the procedure results in stability of the ocular surface over a period of more than 12 months in most patients, it may be considered an alternative to conventional surgical techniques for ocular surface reconstruction.

Authors+Show Affiliations

Department of Ophthalmology, University of Heidelberg, Germany. Friedrich_Kruse@ukl.uni-heidelberg.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10442895

Citation

Kruse, F E., et al. "Multilayer Amniotic Membrane Transplantation for Reconstruction of Deep Corneal Ulcers." Ophthalmology, vol. 106, no. 8, 1999, pp. 1504-10; discussion 1511.
Kruse FE, Rohrschneider K, Völcker HE. Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers. Ophthalmology. 1999;106(8):1504-10; discussion 1511.
Kruse, F. E., Rohrschneider, K., & Völcker, H. E. (1999). Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers. Ophthalmology, 106(8), pp. 1504-10; discussion 1511.
Kruse FE, Rohrschneider K, Völcker HE. Multilayer Amniotic Membrane Transplantation for Reconstruction of Deep Corneal Ulcers. Ophthalmology. 1999;106(8):1504-10; discussion 1511. PubMed PMID: 10442895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers. AU - Kruse,F E, AU - Rohrschneider,K, AU - Völcker,H E, PY - 1999/8/12/pubmed PY - 1999/8/12/medline PY - 1999/8/12/entrez SP - 1504-10; discussion 1511 JF - Ophthalmology JO - Ophthalmology VL - 106 IS - 8 N2 - PURPOSE: To evaluate the efficacy of multilayer amniotic membrane transplantation for reconstruction of corneal epithelium and stroma in the context of deep corneal ulcers. DESIGN: Prospective, noncomparative, interventional case series. PARTICIPANTS: Eleven consecutive patients with deep corneal ulcers refractory to conventional treatment; six patients had herpetic keratitis and five had other forms of neurotrophic keratitis. INTERVENTION: Multilayer amniotic membrane transplantation with kryopreserved human amniotic membrane. MAIN OUTCOME MEASURES: Integrity of corneal epithelium and stroma, opacification, and appearance of grafted membrane during 12 months follow-up. RESULTS: Amniotic membrane transplantation markedly reduced ocular inflammation in all patients. Epithelium healed above all corneal ulcers within 4 weeks and remained stable in 9 of 11 patients for 1 year. Two patients with recurrent epithelial defect suffered from severe neurotrophic keratitis. Following transplantation the amniotic membranes gradually dissolved over a period of 12 months, but stromal thickness remained stable. CONCLUSION: Amniotic membrane transplantation allows corneal surface reconstruction in patients with persistent epithelial defects. The multilayer technique is useful for treating deep corneal ulcers and even descemetoceles. Because the procedure results in stability of the ocular surface over a period of more than 12 months in most patients, it may be considered an alternative to conventional surgical techniques for ocular surface reconstruction. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/10442895/Multilayer_amniotic_membrane_transplantation_for_reconstruction_of_deep_corneal_ulcers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(99)90444-X DB - PRIME DP - Unbound Medicine ER -