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Diet and benign prostatic hyperplasia: a study in Greece.

Abstract

OBJECTIVES

To evaluate the nutritional etiology of benign prostatic hyperplasia (BPH) by conducting a case-control study in Athens, Greece. Despite the high morbidity and substantial human suffering produced by BPH, little research has been undertaken concerning the nutritional etiology of this disease.

METHODS

The study sample consisted of 184 patients with histologically confirmed BPH and 246 control patients without clinical evidence of prostate disease. All patients and controls were permanent residents of the greater Athens area. The data were modeled through unconditional logistic regression.

RESULTS

Among the food groups, fruits were inversely related to BPH risk, with a logistic regression-derived odds ratio of 0.79 per quintile increase and 95% confidence interval 0.67 to 0.93. Increased consumption of both butter and margarine was positively associated with BPH risk, and a marginally significant positive association was also evident for seed oils. No overall association was found with respect to consumption of olive oil. In analyses evaluating the role of nutrients rather than foods, zinc, an element selectively concentrated in the prostate gland, was significantly positively associated with BPH risk.

CONCLUSIONS

Our study provides evidence that, among added lipids, butter and margarine may increase the risk of BPH, and fruit intake may reduce this risk. Dietary zinc may play an important role in the etiology of BPH.

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  • Authors+Show Affiliations

    ,

    Department of Hygiene and Epidemiology, University of Athens Medical School, Greece.

    , , , ,

    Source

    Urology 54:2 1999 Aug pg 284-90

    MeSH

    Case-Control Studies
    Diet
    Greece
    Humans
    Logistic Models
    Male
    Middle Aged
    Prostatic Hyperplasia

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10443726

    Citation

    Lagiou, P, et al. "Diet and Benign Prostatic Hyperplasia: a Study in Greece." Urology, vol. 54, no. 2, 1999, pp. 284-90.
    Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology. 1999;54(2):284-90.
    Lagiou, P., Wuu, J., Trichopoulou, A., Hsieh, C. C., Adami, H. O., & Trichopoulos, D. (1999). Diet and benign prostatic hyperplasia: a study in Greece. Urology, 54(2), pp. 284-90.
    Lagiou P, et al. Diet and Benign Prostatic Hyperplasia: a Study in Greece. Urology. 1999;54(2):284-90. PubMed PMID: 10443726.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet and benign prostatic hyperplasia: a study in Greece. AU - Lagiou,P, AU - Wuu,J, AU - Trichopoulou,A, AU - Hsieh,C C, AU - Adami,H O, AU - Trichopoulos,D, PY - 1999/8/12/pubmed PY - 1999/8/12/medline PY - 1999/8/12/entrez SP - 284 EP - 90 JF - Urology JO - Urology VL - 54 IS - 2 N2 - OBJECTIVES: To evaluate the nutritional etiology of benign prostatic hyperplasia (BPH) by conducting a case-control study in Athens, Greece. Despite the high morbidity and substantial human suffering produced by BPH, little research has been undertaken concerning the nutritional etiology of this disease. METHODS: The study sample consisted of 184 patients with histologically confirmed BPH and 246 control patients without clinical evidence of prostate disease. All patients and controls were permanent residents of the greater Athens area. The data were modeled through unconditional logistic regression. RESULTS: Among the food groups, fruits were inversely related to BPH risk, with a logistic regression-derived odds ratio of 0.79 per quintile increase and 95% confidence interval 0.67 to 0.93. Increased consumption of both butter and margarine was positively associated with BPH risk, and a marginally significant positive association was also evident for seed oils. No overall association was found with respect to consumption of olive oil. In analyses evaluating the role of nutrients rather than foods, zinc, an element selectively concentrated in the prostate gland, was significantly positively associated with BPH risk. CONCLUSIONS: Our study provides evidence that, among added lipids, butter and margarine may increase the risk of BPH, and fruit intake may reduce this risk. Dietary zinc may play an important role in the etiology of BPH. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/10443726/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(99)00096-5 DB - PRIME DP - Unbound Medicine ER -