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The incidence of adenocarcinoma and dysplasia in Barrett's esophagus: report on the Cleveland Clinic Barrett's Esophagus Registry.
Am J Gastroenterol. 1999 Aug; 94(8):2037-42.AJ

Abstract

OBJECTIVE

The reported incidence of adenocarcinoma in Barrett's esophagus is variable. The aim of this study was to determine the incidence of dysplasia and adenocarcinoma in a population of patients with Barrett's esophagus followed prospectively and to compare these findings with other series.

METHODS

All patients enrolled in the Cleveland Clinic Foundation's Barrett's esophagus registry from 1979 to 1995 were followed. Barrett's esophagus was defined as intestinal metaplasia anywhere in the tubular esophagus. The incidence of dysplasia and adenocarcinoma in these patients was recorded systematically.

RESULTS

A total of 136 patients (91 male, 45 female) were followed in an endoscopic surveillance program for a mean of 4.2 yr and a total of 570 patient-years of follow-up. Thirty patients (22%) had short segment Barrett's esophagus. Two adenocarcinomas developed during follow-up, yielding an incidence of one per 285 patient-years of follow-up. Low grade dysplasia developed in 24 patients, whereas high grade dysplasia developed in four patients.

CONCLUSIONS

Our study suggests that the incidence of adenocarcinoma in Barrett's esophagus is lower than initially thought. However, large multicenter studies are required to clarify the epidemiological and clinical factors related to the development of dysplasia and adenocarcinoma in Barrett's esophagus.

Authors+Show Affiliations

Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, Cleveland Clinic Foundation, Ohio 44195, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10445525

Citation

O'Connor, J B., et al. "The Incidence of Adenocarcinoma and Dysplasia in Barrett's Esophagus: Report On the Cleveland Clinic Barrett's Esophagus Registry." The American Journal of Gastroenterology, vol. 94, no. 8, 1999, pp. 2037-42.
O'Connor JB, Falk GW, Richter JE. The incidence of adenocarcinoma and dysplasia in Barrett's esophagus: report on the Cleveland Clinic Barrett's Esophagus Registry. Am J Gastroenterol. 1999;94(8):2037-42.
O'Connor, J. B., Falk, G. W., & Richter, J. E. (1999). The incidence of adenocarcinoma and dysplasia in Barrett's esophagus: report on the Cleveland Clinic Barrett's Esophagus Registry. The American Journal of Gastroenterology, 94(8), 2037-42.
O'Connor JB, Falk GW, Richter JE. The Incidence of Adenocarcinoma and Dysplasia in Barrett's Esophagus: Report On the Cleveland Clinic Barrett's Esophagus Registry. Am J Gastroenterol. 1999;94(8):2037-42. PubMed PMID: 10445525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The incidence of adenocarcinoma and dysplasia in Barrett's esophagus: report on the Cleveland Clinic Barrett's Esophagus Registry. AU - O'Connor,J B, AU - Falk,G W, AU - Richter,J E, PY - 1999/8/13/pubmed PY - 1999/8/13/medline PY - 1999/8/13/entrez SP - 2037 EP - 42 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 94 IS - 8 N2 - OBJECTIVE: The reported incidence of adenocarcinoma in Barrett's esophagus is variable. The aim of this study was to determine the incidence of dysplasia and adenocarcinoma in a population of patients with Barrett's esophagus followed prospectively and to compare these findings with other series. METHODS: All patients enrolled in the Cleveland Clinic Foundation's Barrett's esophagus registry from 1979 to 1995 were followed. Barrett's esophagus was defined as intestinal metaplasia anywhere in the tubular esophagus. The incidence of dysplasia and adenocarcinoma in these patients was recorded systematically. RESULTS: A total of 136 patients (91 male, 45 female) were followed in an endoscopic surveillance program for a mean of 4.2 yr and a total of 570 patient-years of follow-up. Thirty patients (22%) had short segment Barrett's esophagus. Two adenocarcinomas developed during follow-up, yielding an incidence of one per 285 patient-years of follow-up. Low grade dysplasia developed in 24 patients, whereas high grade dysplasia developed in four patients. CONCLUSIONS: Our study suggests that the incidence of adenocarcinoma in Barrett's esophagus is lower than initially thought. However, large multicenter studies are required to clarify the epidemiological and clinical factors related to the development of dysplasia and adenocarcinoma in Barrett's esophagus. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10445525/The_incidence_of_adenocarcinoma_and_dysplasia_in_Barrett's_esophagus:_report_on_the_Cleveland_Clinic_Barrett's_Esophagus_Registry_ L2 - http://Insights.ovid.com/pubmed?pmid=10445525 DB - PRIME DP - Unbound Medicine ER -