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Predominant symptoms identify different subgroups in functional dyspepsia.
Am J Gastroenterol. 1999 Aug; 94(8):2080-5.AJ

Abstract

OBJECTIVE

Dyspepsia is a common syndrome that often defies diagnosis. Whether the unexplained (or "functional") dyspepsia represents a homogeneous syndrome or includes different subgroups with specific clinical features has not been clarified. The aim of this study was to investigate the relationship between symptom severity, demographic features, and gastric dysmotility in a large series of patients with functional dyspepsia.

METHODS

Severity of individual digestive symptoms, demographic features, and scintigraphic gastric emptying of solids were evaluated in 483 patients with chronic unexplained dyspepsia.

RESULTS

Two main subgroups were identified. The first was characterized by predominant epigastric pain, male gender (61%), and normal gastric emptying. The second subgroup was characterized by predominant nonpainful symptoms, female gender (60%), a high frequency of associated irritable bowel syndrome (30%), and delayed gastric emptying (42%). A third group included approximately one-third of patients who did not present with any predominant symptom, and was characterized by a high frequency of delayed gastric emptying (30%), overlapping irritable bowel syndrome (28%), and gastroesophageal reflux disease (41%).

CONCLUSIONS

Different subgroups exist among patients with functional dyspepsia seen in a referral center. They can be identified by the predominant symptom and are characterized by different demographic, clinical, and pathophysiological features.

Authors+Show Affiliations

Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10445531

Citation

Stanghellini, V, et al. "Predominant Symptoms Identify Different Subgroups in Functional Dyspepsia." The American Journal of Gastroenterology, vol. 94, no. 8, 1999, pp. 2080-5.
Stanghellini V, Tosetti C, Paternicò A, et al. Predominant symptoms identify different subgroups in functional dyspepsia. Am J Gastroenterol. 1999;94(8):2080-5.
Stanghellini, V., Tosetti, C., Paternicò, A., De Giorgio, R., Barbara, G., Salvioli, B., & Corinaldesi, R. (1999). Predominant symptoms identify different subgroups in functional dyspepsia. The American Journal of Gastroenterology, 94(8), 2080-5.
Stanghellini V, et al. Predominant Symptoms Identify Different Subgroups in Functional Dyspepsia. Am J Gastroenterol. 1999;94(8):2080-5. PubMed PMID: 10445531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predominant symptoms identify different subgroups in functional dyspepsia. AU - Stanghellini,V, AU - Tosetti,C, AU - Paternicò,A, AU - De Giorgio,R, AU - Barbara,G, AU - Salvioli,B, AU - Corinaldesi,R, PY - 1999/8/13/pubmed PY - 1999/8/13/medline PY - 1999/8/13/entrez SP - 2080 EP - 5 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 94 IS - 8 N2 - OBJECTIVE: Dyspepsia is a common syndrome that often defies diagnosis. Whether the unexplained (or "functional") dyspepsia represents a homogeneous syndrome or includes different subgroups with specific clinical features has not been clarified. The aim of this study was to investigate the relationship between symptom severity, demographic features, and gastric dysmotility in a large series of patients with functional dyspepsia. METHODS: Severity of individual digestive symptoms, demographic features, and scintigraphic gastric emptying of solids were evaluated in 483 patients with chronic unexplained dyspepsia. RESULTS: Two main subgroups were identified. The first was characterized by predominant epigastric pain, male gender (61%), and normal gastric emptying. The second subgroup was characterized by predominant nonpainful symptoms, female gender (60%), a high frequency of associated irritable bowel syndrome (30%), and delayed gastric emptying (42%). A third group included approximately one-third of patients who did not present with any predominant symptom, and was characterized by a high frequency of delayed gastric emptying (30%), overlapping irritable bowel syndrome (28%), and gastroesophageal reflux disease (41%). CONCLUSIONS: Different subgroups exist among patients with functional dyspepsia seen in a referral center. They can be identified by the predominant symptom and are characterized by different demographic, clinical, and pathophysiological features. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10445531/Predominant_symptoms_identify_different_subgroups_in_functional_dyspepsia_ L2 - https://Insights.ovid.com/pubmed?pmid=10445531 DB - PRIME DP - Unbound Medicine ER -