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Effect of extra-virgin olive oil and fish-oil supplementation on plasma lipids and susceptibility of low-density lipoprotein to oxidative alteration in free-living spanish male patients with peripheral vascular disease.
Clin Nutr 1999; 18(3):167-74CN

Abstract

The aim of this study was to analyse the in vivo effect of a diet rich in extra-virgin olive oil and a fish-oil supplement on plasma and lipoprotein fatty-acid composition and on LDL susceptibility to oxidative modification in free-living Spanish male patients with peripheral vascular disease. A total of 12 patients were included in the experimental group which received extra virgin olive oil and a fish oil supplement (group OF). On the other hand, 13 patients which had refined olive oil as the main visible fat were considered as Control group. Plasma triglycerides decreased significantly after three months of dietary intervention. The LDL and plasma fatty-acid pattern in the group OF was characterized by a significant increase in n-3 polyunsaturated fatty acids, mainly 20:5 n-3 and 22:6 n-3. The slopes of LDL oxidative susceptibility were similar between baseline and endpoint values in both groups. However, the uptake of oxidized LDL by macrophages was significantly reduced in OF patients in comparison with the Control group. In conclusion, the daily intake of about 40 g/d of extra-virgin olive oil in combination with a daily supplement of 16 g of fish oil for 3 months in patients with peripheral vascular disease leads to a plasma-lipid profile less atherogenic than in patients having refined olive oil as the main visible food fat. The simultaneous consumption of alpha-tocopherol and natural antioxidants provided by extra-virgin olive oil seems to have a protective effect on the LDL susceptibility to oxidative modifications in spite of a higher proportion of n-3 polyunsaturated fatty acids.

Authors+Show Affiliations

Institute of Nutrition and Food Technology, University of Granada, Granada, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10451477

Citation

Ramírez-Tortosa, M C., et al. "Effect of Extra-virgin Olive Oil and Fish-oil Supplementation On Plasma Lipids and Susceptibility of Low-density Lipoprotein to Oxidative Alteration in Free-living Spanish Male Patients With Peripheral Vascular Disease." Clinical Nutrition (Edinburgh, Scotland), vol. 18, no. 3, 1999, pp. 167-74.
Ramírez-Tortosa MC, Suárez A, Gómez MC, et al. Effect of extra-virgin olive oil and fish-oil supplementation on plasma lipids and susceptibility of low-density lipoprotein to oxidative alteration in free-living spanish male patients with peripheral vascular disease. Clin Nutr. 1999;18(3):167-74.
Ramírez-Tortosa, M. C., Suárez, A., Gómez, M. C., Mir, A., Ros, E., Mataix, J., & Gil, A. (1999). Effect of extra-virgin olive oil and fish-oil supplementation on plasma lipids and susceptibility of low-density lipoprotein to oxidative alteration in free-living spanish male patients with peripheral vascular disease. Clinical Nutrition (Edinburgh, Scotland), 18(3), pp. 167-74.
Ramírez-Tortosa MC, et al. Effect of Extra-virgin Olive Oil and Fish-oil Supplementation On Plasma Lipids and Susceptibility of Low-density Lipoprotein to Oxidative Alteration in Free-living Spanish Male Patients With Peripheral Vascular Disease. Clin Nutr. 1999;18(3):167-74. PubMed PMID: 10451477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of extra-virgin olive oil and fish-oil supplementation on plasma lipids and susceptibility of low-density lipoprotein to oxidative alteration in free-living spanish male patients with peripheral vascular disease. AU - Ramírez-Tortosa,M C, AU - Suárez,A, AU - Gómez,M C, AU - Mir,A, AU - Ros,E, AU - Mataix,J, AU - Gil,A, PY - 1999/8/19/pubmed PY - 1999/8/19/medline PY - 1999/8/19/entrez SP - 167 EP - 74 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 18 IS - 3 N2 - The aim of this study was to analyse the in vivo effect of a diet rich in extra-virgin olive oil and a fish-oil supplement on plasma and lipoprotein fatty-acid composition and on LDL susceptibility to oxidative modification in free-living Spanish male patients with peripheral vascular disease. A total of 12 patients were included in the experimental group which received extra virgin olive oil and a fish oil supplement (group OF). On the other hand, 13 patients which had refined olive oil as the main visible fat were considered as Control group. Plasma triglycerides decreased significantly after three months of dietary intervention. The LDL and plasma fatty-acid pattern in the group OF was characterized by a significant increase in n-3 polyunsaturated fatty acids, mainly 20:5 n-3 and 22:6 n-3. The slopes of LDL oxidative susceptibility were similar between baseline and endpoint values in both groups. However, the uptake of oxidized LDL by macrophages was significantly reduced in OF patients in comparison with the Control group. In conclusion, the daily intake of about 40 g/d of extra-virgin olive oil in combination with a daily supplement of 16 g of fish oil for 3 months in patients with peripheral vascular disease leads to a plasma-lipid profile less atherogenic than in patients having refined olive oil as the main visible food fat. The simultaneous consumption of alpha-tocopherol and natural antioxidants provided by extra-virgin olive oil seems to have a protective effect on the LDL susceptibility to oxidative modifications in spite of a higher proportion of n-3 polyunsaturated fatty acids. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/10451477/Effect_of_extra_virgin_olive_oil_and_fish_oil_supplementation_on_plasma_lipids_and_susceptibility_of_low_density_lipoprotein_to_oxidative_alteration_in_free_living_spanish_male_patients_with_peripheral_vascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/clnu.1999.0025 DB - PRIME DP - Unbound Medicine ER -