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Prenatal diagnosis of a familial form of junctional ectopic tachycardia.
Prenat Diagn 1999; 19(8):767-70PD

Abstract

Junctional ectopic tachycardia (JET) is a rare cardiac arrhythmia characterized by atrio-ventricular dissociation, a high rate junctional escape rhythm and poor clinical tolerance in neonates and infants. Sudden infant death has been reported. The intra-uterine presentation of this arrhythmia is unknown. We report a familial form of JET with antenatal diagnosis. A sustained tachycardia at a rate of 170 beats/min with a 1:1 conduction was diagnosed in a hydropic fetus at a gestational age of 32 weeks. The older brother had presented with prenatal hydrops and junctional ectopic tachycardia was diagnosed at birth. Assuming that this arrhythmia was a JET, amiodarone was given to the mother in order to control the fetal tachycardia. The arrhythmia persisted with a 1/1 pattern but at a slower ventricular rate (140 beats/min). The ECG performed at birth revealed a narrow QRS tachycardia with a ventricular rate of 180 beats/min and a 1/1 retrograde conduction. Amiodarone therapy was continued with the addition of propanolol. Postnatal echocardiography revealed normal chambers and left ventricular dysfunction with a left ventricular shortening fraction of 17 per cent. Subsequent ECGs and Holter monitoring demonstrated typical electrocardiographic features of JET. Both parents had a normal ECG and Holter monitoring. A fetal tachycardia of moderately high rate with a 1/1 retrograde conduction and poor cardiac tolerance can be due to JET. In such cases, the use of amiodarone can be considered as a first line drug.

Authors+Show Affiliations

Paediatric Cardiology Department, Robert Debré Hospital, Paris, France. jean-marc.lupoglazof@rdb.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10451526

Citation

Lupoglazoff, J M., et al. "Prenatal Diagnosis of a Familial Form of Junctional Ectopic Tachycardia." Prenatal Diagnosis, vol. 19, no. 8, 1999, pp. 767-70.
Lupoglazoff JM, Denjoy I, Luton D, et al. Prenatal diagnosis of a familial form of junctional ectopic tachycardia. Prenat Diagn. 1999;19(8):767-70.
Lupoglazoff, J. M., Denjoy, I., Luton, D., Magnier, S., & Azancot, A. (1999). Prenatal diagnosis of a familial form of junctional ectopic tachycardia. Prenatal Diagnosis, 19(8), pp. 767-70.
Lupoglazoff JM, et al. Prenatal Diagnosis of a Familial Form of Junctional Ectopic Tachycardia. Prenat Diagn. 1999;19(8):767-70. PubMed PMID: 10451526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal diagnosis of a familial form of junctional ectopic tachycardia. AU - Lupoglazoff,J M, AU - Denjoy,I, AU - Luton,D, AU - Magnier,S, AU - Azancot,A, PY - 1999/8/19/pubmed PY - 1999/8/19/medline PY - 1999/8/19/entrez SP - 767 EP - 70 JF - Prenatal diagnosis JO - Prenat. Diagn. VL - 19 IS - 8 N2 - Junctional ectopic tachycardia (JET) is a rare cardiac arrhythmia characterized by atrio-ventricular dissociation, a high rate junctional escape rhythm and poor clinical tolerance in neonates and infants. Sudden infant death has been reported. The intra-uterine presentation of this arrhythmia is unknown. We report a familial form of JET with antenatal diagnosis. A sustained tachycardia at a rate of 170 beats/min with a 1:1 conduction was diagnosed in a hydropic fetus at a gestational age of 32 weeks. The older brother had presented with prenatal hydrops and junctional ectopic tachycardia was diagnosed at birth. Assuming that this arrhythmia was a JET, amiodarone was given to the mother in order to control the fetal tachycardia. The arrhythmia persisted with a 1/1 pattern but at a slower ventricular rate (140 beats/min). The ECG performed at birth revealed a narrow QRS tachycardia with a ventricular rate of 180 beats/min and a 1/1 retrograde conduction. Amiodarone therapy was continued with the addition of propanolol. Postnatal echocardiography revealed normal chambers and left ventricular dysfunction with a left ventricular shortening fraction of 17 per cent. Subsequent ECGs and Holter monitoring demonstrated typical electrocardiographic features of JET. Both parents had a normal ECG and Holter monitoring. A fetal tachycardia of moderately high rate with a 1/1 retrograde conduction and poor cardiac tolerance can be due to JET. In such cases, the use of amiodarone can be considered as a first line drug. SN - 0197-3851 UR - https://www.unboundmedicine.com/medline/citation/10451526/Prenatal_diagnosis_of_a_familial_form_of_junctional_ectopic_tachycardia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0197-3851&date=1999&volume=19&issue=8&spage=767 DB - PRIME DP - Unbound Medicine ER -