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[Cross neutralization of bothrops jararacussu venom by heterologous antivenoms].
Medicina (B Aires). 1999; 59(3):238-42.M

Abstract

We have studied the immunochemical cross-reactivity and cross-neutralization of the lethal potency, hemorrhagic, necrotizing, procoagulant and (indirect) hemolytic activities of Bothrops jararacussu venom by the standard antivenoms produced in Argentina. These antivenoms are horse immunoglobulin F (ab')2 fragments from animals immunized with 1) Crotalus durissus terrificus venom (Monovalent Anticrotalic antivenom); 2) Bothrops alternatus and B. neuwiedii venoms (Bivalent Botropic antivenom); 3) B. alternatus, B. neuwiedii, B. jararaca and B. jararacussu venoms (Tetravalent Bothropic, or "Misiones" antivenom) and 4) B. alternatus, B. neuwiedii and C. d. terrificus venoms (Trivalent Botropic-Crotalic antivenom). In preincubation experiments, all the heterologous antivenoms neutralized the toxic and biological activities of B. jararacussu venom with a potency at least as high as the Tetravalent Botropic (i.e. the only homologous) antivenom, in which B. jararacussu venom was included as immunogen. These results suggest the possibility of using heterologous antibothropic antivenoms for the treatment of snake bites by B. jararacussu.

Authors+Show Affiliations

de Roodt AR
Instituto Nacional de Producción de Biológicos ANLIS Dr. Carlos G. Malbrán, Ministerio de Salud, Buenos Aires, Argentina. aderoodt@ba.net
Vidal JC
No affiliation info available
Litwin S
No affiliation info available
Dokmetjian JC
No affiliation info available
Dolab JA
No affiliation info available
Hajos SE
No affiliation info available
Segré L
No affiliation info available

MeSH

AnimalsAntiveninsBothropsCross ReactionsCrotalid VenomsNeutralization TestsRatsSnake Bites

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

10451561

Citation

de Roodt, A R., et al. "[Cross Neutralization of Bothrops Jararacussu Venom By Heterologous Antivenoms]." Medicina, vol. 59, no. 3, 1999, pp. 238-42.
de Roodt AR, Vidal JC, Litwin S, et al. [Cross neutralization of bothrops jararacussu venom by heterologous antivenoms]. Medicina (B Aires). 1999;59(3):238-42.
de Roodt, A. R., Vidal, J. C., Litwin, S., Dokmetjian, J. C., Dolab, J. A., Hajos, S. E., & Segré, L. (1999). [Cross neutralization of bothrops jararacussu venom by heterologous antivenoms]. Medicina, 59(3), 238-42.
de Roodt AR, et al. [Cross Neutralization of Bothrops Jararacussu Venom By Heterologous Antivenoms]. Medicina (B Aires). 1999;59(3):238-42. PubMed PMID: 10451561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cross neutralization of bothrops jararacussu venom by heterologous antivenoms]. AU - de Roodt,A R, AU - Vidal,J C, AU - Litwin,S, AU - Dokmetjian,J C, AU - Dolab,J A, AU - Hajos,S E, AU - Segré,L, PY - 1999/8/19/pubmed PY - 1999/8/19/medline PY - 1999/8/19/entrez SP - 238 EP - 42 JF - Medicina JO - Medicina (B Aires) VL - 59 IS - 3 N2 - We have studied the immunochemical cross-reactivity and cross-neutralization of the lethal potency, hemorrhagic, necrotizing, procoagulant and (indirect) hemolytic activities of Bothrops jararacussu venom by the standard antivenoms produced in Argentina. These antivenoms are horse immunoglobulin F (ab')2 fragments from animals immunized with 1) Crotalus durissus terrificus venom (Monovalent Anticrotalic antivenom); 2) Bothrops alternatus and B. neuwiedii venoms (Bivalent Botropic antivenom); 3) B. alternatus, B. neuwiedii, B. jararaca and B. jararacussu venoms (Tetravalent Bothropic, or "Misiones" antivenom) and 4) B. alternatus, B. neuwiedii and C. d. terrificus venoms (Trivalent Botropic-Crotalic antivenom). In preincubation experiments, all the heterologous antivenoms neutralized the toxic and biological activities of B. jararacussu venom with a potency at least as high as the Tetravalent Botropic (i.e. the only homologous) antivenom, in which B. jararacussu venom was included as immunogen. These results suggest the possibility of using heterologous antibothropic antivenoms for the treatment of snake bites by B. jararacussu. SN - 0025-7680 UR - https://www.unboundmedicine.com/medline/citation/10451561/[Cross_neutralization_of_bothrops_jararacussu_venom_by_heterologous_antivenoms]_ DB - PRIME DP - Unbound Medicine ER -