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Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans.
Psychoneuroendocrinology. 1999 Oct; 24(7):743-57.P

Abstract

Systemic administration of growth hormone-releasing hormone (GHRH) has been found to improve human sleep in previous studies. Here we examined effects of GHRH on endocrine function and sleep after intranasal administration, a method which based on previous studies appears to enable a direct effect of peptides on brain function. Also, it was hypothesized that elderly humans displaying deficient GH release and sleep, benefit from GHRH administration more than young subjects. A study was performed according to a double-blind cross-over design. Each of 12 young and 11 old healthy men were intranasally administered with 300 micrograms GHRH (vs. placebo) 30 min before bedtime at 23:00 h. Sleep was recorded polysomnographically until 07:00 h and blood was collected in 15 min intervals for determination of cortisol and GH. Apart from the well-known age-related changes of hormonal secretion and sleep, intranasal GHRH reduced cortisol nadir concentrations in the beginning of sleep (P < 0.05), and also reduced the sleep-induced elevation in GH concentrations during early sleep. Moreover, results indicated that after intranasal administration GHRH increased rapid-eye-movement (REM) sleep and slow wave sleep (SWS), with this influence concentrating on the second half of sleep time. Effects of GHRH did not depend on the subject's age. We conclude that there is a coordinate influence of intranasal GHRH on the central nervous regulation of sleep processes and of hypothalamic-hypophysiotropic secretory activity in both young and elderly men. The effects may mimic the dual neuronal and endocrine function of hypothalamic GHRH activity.

Authors+Show Affiliations

Department of Clinical Neuroendocrinology, University of Lübeck, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10451909

Citation

Perras, B, et al. "Sleep and Endocrine Changes After Intranasal Administration of Growth Hormone-releasing Hormone in Young and Aged Humans." Psychoneuroendocrinology, vol. 24, no. 7, 1999, pp. 743-57.
Perras B, Marshall L, Köhler G, et al. Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans. Psychoneuroendocrinology. 1999;24(7):743-57.
Perras, B., Marshall, L., Köhler, G., Born, J., & Fehm, H. L. (1999). Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans. Psychoneuroendocrinology, 24(7), 743-57.
Perras B, et al. Sleep and Endocrine Changes After Intranasal Administration of Growth Hormone-releasing Hormone in Young and Aged Humans. Psychoneuroendocrinology. 1999;24(7):743-57. PubMed PMID: 10451909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans. AU - Perras,B, AU - Marshall,L, AU - Köhler,G, AU - Born,J, AU - Fehm,H L, PY - 1999/8/19/pubmed PY - 1999/8/19/medline PY - 1999/8/19/entrez SP - 743 EP - 57 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 24 IS - 7 N2 - Systemic administration of growth hormone-releasing hormone (GHRH) has been found to improve human sleep in previous studies. Here we examined effects of GHRH on endocrine function and sleep after intranasal administration, a method which based on previous studies appears to enable a direct effect of peptides on brain function. Also, it was hypothesized that elderly humans displaying deficient GH release and sleep, benefit from GHRH administration more than young subjects. A study was performed according to a double-blind cross-over design. Each of 12 young and 11 old healthy men were intranasally administered with 300 micrograms GHRH (vs. placebo) 30 min before bedtime at 23:00 h. Sleep was recorded polysomnographically until 07:00 h and blood was collected in 15 min intervals for determination of cortisol and GH. Apart from the well-known age-related changes of hormonal secretion and sleep, intranasal GHRH reduced cortisol nadir concentrations in the beginning of sleep (P < 0.05), and also reduced the sleep-induced elevation in GH concentrations during early sleep. Moreover, results indicated that after intranasal administration GHRH increased rapid-eye-movement (REM) sleep and slow wave sleep (SWS), with this influence concentrating on the second half of sleep time. Effects of GHRH did not depend on the subject's age. We conclude that there is a coordinate influence of intranasal GHRH on the central nervous regulation of sleep processes and of hypothalamic-hypophysiotropic secretory activity in both young and elderly men. The effects may mimic the dual neuronal and endocrine function of hypothalamic GHRH activity. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/10451909/Sleep_and_endocrine_changes_after_intranasal_administration_of_growth_hormone_releasing_hormone_in_young_and_aged_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(99)00027-X DB - PRIME DP - Unbound Medicine ER -