Tags

Type your tag names separated by a space and hit enter

Activity of the pituitary-ovarian axis in the pill-free interval during use of low-dose combined oral contraceptives.
Contraception. 1999 Apr; 59(4):237-43.C

Abstract

This study was performed to evaluate pituitary-ovarian recovery in the pill-free interval during use of three low-dose combined oral contraceptives (COC). Either the estrogen component or the progestin component was comparable in the study groups, to evaluate their relative influence. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol (E2) levels were measured and follicle number and size estimated by transvaginal sonography daily during the 7-day pill-free interval in 44 healthy volunteers using three different low-dose oral contraceptives. Healthy volunteers were enrolled using 20 micrograms ethinyl estradiol (EE) + 75 micrograms gestodene (GSD) (Harmonet, Wyeth-Lederle; n = 15), 20 micrograms EE + 150 micrograms desogestrel (DSG) (Mercilon, Organon n = 17), or 30 micrograms EE + 150 micrograms DSG (Marvelon, Organon, n = 12) given according to the usual regimen of one tablet daily during 3 weeks and 1 week pill-free interval. No ovulations were observed. Pituitary hormones were not statistically significantly different at the beginning of the pill-free interval between the study groups. FSH concentrations were significantly higher at the end of the pill-free interval in the 30 micrograms EE group compared with both 20 micrograms EE groups (7.0 [0.6-12.4] IU/L vs 4.9 [1.4-6.1] IU/L and 4.5 [2.4-7.4] IU/L; p = 0.001). In both 20 micrograms EE groups, a single persistent follicle (24 and 28 mm) was present in one subject. Follicle diameters were statistically significantly smaller at the beginning and at the end of the pill-free period in the 30 micrograms EE group compared with both 20 micrograms EE study groups. Dominant follicles (defined as follicle diameter > or = 10 mm) were observed at the end of the pill-free interval in both 20 micrograms EE groups (in 27% and 18% of women, respectively) but not in the 30 micrograms EE group. Finally, the area-under-the-curve for E2 was statistically significantly lower in the 30 micrograms EE group compared with both 20 micrograms EE groups. In conclusion, the EE content rather than the progestin component in the studied COC determined the extent of residual ovarian activity at the beginning of the pill-free interval. Dominant follicles were encountered only in the 20 micrograms EE study groups.

Authors+Show Affiliations

Department of Obstetrics & Gynecology, University Hospital Rotterdam, The Netherlands.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10457868

Citation

van Heusden, A M., and B C. Fauser. "Activity of the Pituitary-ovarian Axis in the Pill-free Interval During Use of Low-dose Combined Oral Contraceptives." Contraception, vol. 59, no. 4, 1999, pp. 237-43.
van Heusden AM, Fauser BC. Activity of the pituitary-ovarian axis in the pill-free interval during use of low-dose combined oral contraceptives. Contraception. 1999;59(4):237-43.
van Heusden, A. M., & Fauser, B. C. (1999). Activity of the pituitary-ovarian axis in the pill-free interval during use of low-dose combined oral contraceptives. Contraception, 59(4), 237-43.
van Heusden AM, Fauser BC. Activity of the Pituitary-ovarian Axis in the Pill-free Interval During Use of Low-dose Combined Oral Contraceptives. Contraception. 1999;59(4):237-43. PubMed PMID: 10457868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activity of the pituitary-ovarian axis in the pill-free interval during use of low-dose combined oral contraceptives. AU - van Heusden,A M, AU - Fauser,B C, PY - 1999/8/24/pubmed PY - 1999/8/24/medline PY - 1999/8/24/entrez KW - Biology KW - Clinical Research KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Desogestrel KW - Endocrine System KW - Ethinyl Estradiol KW - Family Planning KW - Follicle Stimulating Hormone--analysis KW - Genitalia KW - Genitalia, Female KW - Gestodene KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Low-dose KW - Ovarian Effects KW - Ovary KW - Physiology KW - Research Methodology KW - Research Report KW - Urogenital System SP - 237 EP - 43 JF - Contraception JO - Contraception VL - 59 IS - 4 N2 - This study was performed to evaluate pituitary-ovarian recovery in the pill-free interval during use of three low-dose combined oral contraceptives (COC). Either the estrogen component or the progestin component was comparable in the study groups, to evaluate their relative influence. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol (E2) levels were measured and follicle number and size estimated by transvaginal sonography daily during the 7-day pill-free interval in 44 healthy volunteers using three different low-dose oral contraceptives. Healthy volunteers were enrolled using 20 micrograms ethinyl estradiol (EE) + 75 micrograms gestodene (GSD) (Harmonet, Wyeth-Lederle; n = 15), 20 micrograms EE + 150 micrograms desogestrel (DSG) (Mercilon, Organon n = 17), or 30 micrograms EE + 150 micrograms DSG (Marvelon, Organon, n = 12) given according to the usual regimen of one tablet daily during 3 weeks and 1 week pill-free interval. No ovulations were observed. Pituitary hormones were not statistically significantly different at the beginning of the pill-free interval between the study groups. FSH concentrations were significantly higher at the end of the pill-free interval in the 30 micrograms EE group compared with both 20 micrograms EE groups (7.0 [0.6-12.4] IU/L vs 4.9 [1.4-6.1] IU/L and 4.5 [2.4-7.4] IU/L; p = 0.001). In both 20 micrograms EE groups, a single persistent follicle (24 and 28 mm) was present in one subject. Follicle diameters were statistically significantly smaller at the beginning and at the end of the pill-free period in the 30 micrograms EE group compared with both 20 micrograms EE study groups. Dominant follicles (defined as follicle diameter > or = 10 mm) were observed at the end of the pill-free interval in both 20 micrograms EE groups (in 27% and 18% of women, respectively) but not in the 30 micrograms EE group. Finally, the area-under-the-curve for E2 was statistically significantly lower in the 30 micrograms EE group compared with both 20 micrograms EE groups. In conclusion, the EE content rather than the progestin component in the studied COC determined the extent of residual ovarian activity at the beginning of the pill-free interval. Dominant follicles were encountered only in the 20 micrograms EE study groups. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/10457868/Activity_of_the_pituitary_ovarian_axis_in_the_pill_free_interval_during_use_of_low_dose_combined_oral_contraceptives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(99)00025-6 DB - PRIME DP - Unbound Medicine ER -