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p190 BCR-ABL rearrangement in chronic myeloid leukemia and acute lymphoblastic leukemia.
Cancer Genet Cytogenet 1999; 113(1):100-2CG

Abstract

A minority of chronic myeloid leukemia (CML) cases have breakpoint in the minor cluster region (m-bcr) of the BCR-ABL fusion gene. We report a patient with Ph-positive acute lymphoblastic leukemia and m-bcr breakpoint at diagnosis. The patient was treated with chemotherapy followed by an autologous peripheral blood stem cell transplantation, achieving a clinical and hematological complete remission but with persistence of the Philadelphia chromosome. One year later, she developed leukocytosis with a blood picture consistent with CML. She was treated with hydroxyurea and interferon alpha with no response. This is the second case of m-bcr CML reported presenting with features of lymphoid blast crisis or acute lymphoblastic leukemia.

Authors+Show Affiliations

Servicio de Hematología, Hospital Universitario Na Sra. del Pino, Las Palmas de Gran Canaria, Spain.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10459357

Citation

Lemes, A, et al. "P190 BCR-ABL Rearrangement in Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia." Cancer Genetics and Cytogenetics, vol. 113, no. 1, 1999, pp. 100-2.
Lemes A, Gómez Casares MT, de la Iglesia S, et al. P190 BCR-ABL rearrangement in chronic myeloid leukemia and acute lymphoblastic leukemia. Cancer Genet Cytogenet. 1999;113(1):100-2.
Lemes, A., Gómez Casares, M. T., de la Iglesia, S., Matutes, E., & Molero, M. T. (1999). P190 BCR-ABL rearrangement in chronic myeloid leukemia and acute lymphoblastic leukemia. Cancer Genetics and Cytogenetics, 113(1), pp. 100-2.
Lemes A, et al. P190 BCR-ABL Rearrangement in Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia. Cancer Genet Cytogenet. 1999;113(1):100-2. PubMed PMID: 10459357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - p190 BCR-ABL rearrangement in chronic myeloid leukemia and acute lymphoblastic leukemia. AU - Lemes,A, AU - Gómez Casares,M T, AU - de la Iglesia,S, AU - Matutes,E, AU - Molero,M T, PY - 1999/8/25/pubmed PY - 1999/8/25/medline PY - 1999/8/25/entrez SP - 100 EP - 2 JF - Cancer genetics and cytogenetics JO - Cancer Genet. Cytogenet. VL - 113 IS - 1 N2 - A minority of chronic myeloid leukemia (CML) cases have breakpoint in the minor cluster region (m-bcr) of the BCR-ABL fusion gene. We report a patient with Ph-positive acute lymphoblastic leukemia and m-bcr breakpoint at diagnosis. The patient was treated with chemotherapy followed by an autologous peripheral blood stem cell transplantation, achieving a clinical and hematological complete remission but with persistence of the Philadelphia chromosome. One year later, she developed leukocytosis with a blood picture consistent with CML. She was treated with hydroxyurea and interferon alpha with no response. This is the second case of m-bcr CML reported presenting with features of lymphoid blast crisis or acute lymphoblastic leukemia. SN - 0165-4608 UR - https://www.unboundmedicine.com/medline/citation/10459357/p190_BCR_ABL_rearrangement_in_chronic_myeloid_leukemia_and_acute_lymphoblastic_leukemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S016546089900014X DB - PRIME DP - Unbound Medicine ER -