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Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder.
Biol Psychiatry 1999; 46(4):573-6BP

Abstract

BACKGROUND

Several lines of evidence suggest that brain dopamine function may contribute to some obsessive-compulsive (OC) phenomena. The effects of catecholamine depletion were examined in drug-free patients with obsessive-compulsive disorder (OCD).

METHODS

The tyrosine hydroxylase inhibitor alpha-methyl-para-tyrosine (AMPT) and diphenhydramine hydrochloride (placebo) were administered for three consecutive days, one week apart, to 6 drug-free adult OCD patients without a personal or family history of chronic tics, in a double-blind, randomized design. The effects of AMPT and placebo on OC, depression, anxiety and global clinical symptoms were assessed.

RESULTS

AMPT produced no clinically or statistically significant change in any behavioral ratings, including OC symptom severity, compared with placebo.

CONCLUSIONS

Acute reduction of catecholamine levels does not seem to affect OC symptoms in drug-free patients with OCD. Studies of catecholamine depletion with AMPT in patients with comorbid OCD and chronic tics may be of considerable neurobiological and clinical interest.

Authors+Show Affiliations

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10459409

Citation

Longhurst, J G., et al. "Effects of Catecholamine Depletion With AMPT (alpha-methyl-para-tyrosine) in Obsessive-compulsive Disorder." Biological Psychiatry, vol. 46, no. 4, 1999, pp. 573-6.
Longhurst JG, Carpenter LL, Epperson CN, et al. Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder. Biol Psychiatry. 1999;46(4):573-6.
Longhurst, J. G., Carpenter, L. L., Epperson, C. N., Price, L. H., & McDougle, C. J. (1999). Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder. Biological Psychiatry, 46(4), pp. 573-6.
Longhurst JG, et al. Effects of Catecholamine Depletion With AMPT (alpha-methyl-para-tyrosine) in Obsessive-compulsive Disorder. Biol Psychiatry. 1999 Aug 15;46(4):573-6. PubMed PMID: 10459409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of catecholamine depletion with AMPT (alpha-methyl-para-tyrosine) in obsessive-compulsive disorder. AU - Longhurst,J G, AU - Carpenter,L L, AU - Epperson,C N, AU - Price,L H, AU - McDougle,C J, PY - 1999/8/25/pubmed PY - 1999/8/25/medline PY - 1999/8/25/entrez SP - 573 EP - 6 JF - Biological psychiatry JO - Biol. Psychiatry VL - 46 IS - 4 N2 - BACKGROUND: Several lines of evidence suggest that brain dopamine function may contribute to some obsessive-compulsive (OC) phenomena. The effects of catecholamine depletion were examined in drug-free patients with obsessive-compulsive disorder (OCD). METHODS: The tyrosine hydroxylase inhibitor alpha-methyl-para-tyrosine (AMPT) and diphenhydramine hydrochloride (placebo) were administered for three consecutive days, one week apart, to 6 drug-free adult OCD patients without a personal or family history of chronic tics, in a double-blind, randomized design. The effects of AMPT and placebo on OC, depression, anxiety and global clinical symptoms were assessed. RESULTS: AMPT produced no clinically or statistically significant change in any behavioral ratings, including OC symptom severity, compared with placebo. CONCLUSIONS: Acute reduction of catecholamine levels does not seem to affect OC symptoms in drug-free patients with OCD. Studies of catecholamine depletion with AMPT in patients with comorbid OCD and chronic tics may be of considerable neurobiological and clinical interest. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/10459409/Effects_of_catecholamine_depletion_with_AMPT__alpha_methyl_para_tyrosine__in_obsessive_compulsive_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(99)00019-0 DB - PRIME DP - Unbound Medicine ER -