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Prevalence of coeliac disease in patients with thyroid autoimmunity.

Abstract

The occurrence of autoimmune thyroid disorders among patients with coeliac disease (CD) is well documented, but the exact prevalence of CD among patients with autoimmune thyroid diseases (ATD) is as yet unclear. We screened 150 newly diagnosed patients with ATD by serum endomysial antibody detection (EmA). In 5 subjects (3.3%) EmA positivity was found; all underwent jejunal biopsy. On gluten-free diet an excellent clinical and histological response was recorded with an improvement of hypothyroidism and reduction of the thyroxine dosage. Our data suggest a significant high prevalence (3.3%) of CD in patients with ATD, in particular with Hashimoto's thyroiditis.

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  • Authors+Show Affiliations

    ,

    CNR, Experimental Endocrinology and Oncology Center (CEOS), Department of Cellular and Molecular Biology and Pathology, University Federico II, Naples, Italy.

    , , , , , , , , ,

    Source

    Hormone research 51:3 1999 pg 124-7

    MeSH

    Adolescent
    Adult
    Celiac Disease
    Child
    Diet
    Female
    Glutens
    Humans
    Male
    Thyroiditis, Autoimmune
    Thyrotropin
    Thyroxine

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10461017

    Citation

    TY - JOUR T1 - Prevalence of coeliac disease in patients with thyroid autoimmunity. AU - Valentino,R, AU - Savastano,S, AU - Tommaselli,A P, AU - Dorato,M, AU - Scarpitta,M T, AU - Gigante,M, AU - Micillo,M, AU - Paparo,F, AU - Petrone,E, AU - Lombardi,G, AU - Troncone,R, PY - 1999/8/26/pubmed PY - 1999/8/26/medline PY - 1999/8/26/entrez SP - 124 EP - 7 JF - Hormone research JO - Horm. Res. VL - 51 IS - 3 N2 - The occurrence of autoimmune thyroid disorders among patients with coeliac disease (CD) is well documented, but the exact prevalence of CD among patients with autoimmune thyroid diseases (ATD) is as yet unclear. We screened 150 newly diagnosed patients with ATD by serum endomysial antibody detection (EmA). In 5 subjects (3.3%) EmA positivity was found; all underwent jejunal biopsy. On gluten-free diet an excellent clinical and histological response was recorded with an improvement of hypothyroidism and reduction of the thyroxine dosage. Our data suggest a significant high prevalence (3.3%) of CD in patients with ATD, in particular with Hashimoto's thyroiditis. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/10461017/full_citation L2 - http://www.karger.com?DOI=23344 ER -