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Clinical aspects of ECL-cell abnormalities.
Yale J Biol Med. 1998 May-Aug; 71(3-4):303-10.YJ

Abstract

ECL cell hyperplasia results from hypergastrinemia, and in man this occurs due to achlorhydria in atrophic gastritis (pernicious anemia [PA]) and gastrinoma (Zollinger-Ellison syndrome [ZES]). Progression to neoplasia, i.e., ECL cell carcinoids (usually small, multicentric and non-functional), occurs in some five to 10 percent of patients with PA where they remain gastrin-dependent and reversible by normalization of serum gastrin by antrectomy. Even if untreated, the carcinoids are almost invariably benign and do not cause death. In ZES, ECL cell hyperplasia is progressive due to hypergastrinemia. However, carcinoids develop only in the MEN-I subtype but pose no additional threat of malignancy. A conservative approach is recommended for small multicentric carcinoids, and the tumors do not need removal. By contrast, single, large, non-gastrin-dependent carcinoids represent a different biological and clinical problem and are frequently malignant.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, University of Alabama at Birmingham 35294-0007, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10461361

Citation

Hirschowitz, B I.. "Clinical Aspects of ECL-cell Abnormalities." The Yale Journal of Biology and Medicine, vol. 71, no. 3-4, 1998, pp. 303-10.
Hirschowitz BI. Clinical aspects of ECL-cell abnormalities. Yale J Biol Med. 1998;71(3-4):303-10.
Hirschowitz, B. I. (1998). Clinical aspects of ECL-cell abnormalities. The Yale Journal of Biology and Medicine, 71(3-4), 303-10.
Hirschowitz BI. Clinical Aspects of ECL-cell Abnormalities. Yale J Biol Med. 1998 May-Aug;71(3-4):303-10. PubMed PMID: 10461361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical aspects of ECL-cell abnormalities. A1 - Hirschowitz,B I, PY - 1999/8/26/pubmed PY - 1999/8/26/medline PY - 1999/8/26/entrez SP - 303 EP - 10 JF - The Yale journal of biology and medicine JO - Yale J Biol Med VL - 71 IS - 3-4 N2 - ECL cell hyperplasia results from hypergastrinemia, and in man this occurs due to achlorhydria in atrophic gastritis (pernicious anemia [PA]) and gastrinoma (Zollinger-Ellison syndrome [ZES]). Progression to neoplasia, i.e., ECL cell carcinoids (usually small, multicentric and non-functional), occurs in some five to 10 percent of patients with PA where they remain gastrin-dependent and reversible by normalization of serum gastrin by antrectomy. Even if untreated, the carcinoids are almost invariably benign and do not cause death. In ZES, ECL cell hyperplasia is progressive due to hypergastrinemia. However, carcinoids develop only in the MEN-I subtype but pose no additional threat of malignancy. A conservative approach is recommended for small multicentric carcinoids, and the tumors do not need removal. By contrast, single, large, non-gastrin-dependent carcinoids represent a different biological and clinical problem and are frequently malignant. SN - 0044-0086 UR - https://www.unboundmedicine.com/medline/citation/10461361/Clinical_aspects_of_ECL_cell_abnormalities_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/10461361/ DB - PRIME DP - Unbound Medicine ER -