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Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant-antioxidant imbalance in healthy subjects.
Scand J Clin Lab Invest 1999; 59(4):239-48SJ

Abstract

The purpose of this study was to investigate the effect of eicosapentaenoic and docosahexaenoic acids on plasma lipids and lipoproteins, lipid peroxidation and antioxidant status in healthy humans. A total of 19 healthy volunteers consumed 6 g/day Maxepa fish oil for 3 weeks (1.8 g n-3 fatty acids/day). At baseline and at day 21, we evaluated plasma lipoproteins, plasma and low-density lipoprotein fatty acids, lipid peroxidation markers (malondialdehyde concentration, low-density lipoprotein peroxidation in vitro), and the content of a number of antioxidants (reduced and oxidized glutathione in whole blood, plasma and erythrocyte glutathione peroxidases, plasma vitamin E and beta carotene). Plasma concentrations of total cholesterol, triglycerides, phospholipids, low-density lipoprotein cholesterol and low-density lipoprotein size did not differ significantly after 3 weeks of supplementation. Adding the fish oil to the diet increased the concentration of n-3 very-long-chain polyunsaturated fatty acids and decreased the concentration of n-6 fatty acid and oleic acid in plasma and low-density lipoprotein. Eicosapentaenoic and docosahexaenoic acid supplementation caused elevated values of the high-density lipoprotein cholesterol due to an increment of the high-density lipoprotein 2 fraction and reduced low-density lipoprotein peroxidation rate in vitro. However, we observed an imbalance between oxidizable substrates and antioxidants with an increased lipid peroxidation, whereas the content of reduced glutathione and beta carotene decreased without any variation in vitamin E. Association of antioxidants with n-3 PUFA could prevent lipid peroxidation and enhance the antiatherogenic effects of n-3 polyunsaturated fatty acids.

Authors+Show Affiliations

Laboratoire de Biochimie A, CHU Grenoble, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10463462

Citation

Foulon, T, et al. "Effects of Fish Oil Fatty Acids On Plasma Lipids and Lipoproteins and Oxidant-antioxidant Imbalance in Healthy Subjects." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 59, no. 4, 1999, pp. 239-48.
Foulon T, Richard MJ, Payen N, et al. Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant-antioxidant imbalance in healthy subjects. Scand J Clin Lab Invest. 1999;59(4):239-48.
Foulon, T., Richard, M. J., Payen, N., Bourrain, J. L., Beani, J. C., Laporte, F., & Hadjian, A. (1999). Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant-antioxidant imbalance in healthy subjects. Scandinavian Journal of Clinical and Laboratory Investigation, 59(4), pp. 239-48.
Foulon T, et al. Effects of Fish Oil Fatty Acids On Plasma Lipids and Lipoproteins and Oxidant-antioxidant Imbalance in Healthy Subjects. Scand J Clin Lab Invest. 1999;59(4):239-48. PubMed PMID: 10463462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant-antioxidant imbalance in healthy subjects. AU - Foulon,T, AU - Richard,M J, AU - Payen,N, AU - Bourrain,J L, AU - Beani,J C, AU - Laporte,F, AU - Hadjian,A, PY - 1999/8/27/pubmed PY - 1999/8/27/medline PY - 1999/8/27/entrez SP - 239 EP - 48 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 59 IS - 4 N2 - The purpose of this study was to investigate the effect of eicosapentaenoic and docosahexaenoic acids on plasma lipids and lipoproteins, lipid peroxidation and antioxidant status in healthy humans. A total of 19 healthy volunteers consumed 6 g/day Maxepa fish oil for 3 weeks (1.8 g n-3 fatty acids/day). At baseline and at day 21, we evaluated plasma lipoproteins, plasma and low-density lipoprotein fatty acids, lipid peroxidation markers (malondialdehyde concentration, low-density lipoprotein peroxidation in vitro), and the content of a number of antioxidants (reduced and oxidized glutathione in whole blood, plasma and erythrocyte glutathione peroxidases, plasma vitamin E and beta carotene). Plasma concentrations of total cholesterol, triglycerides, phospholipids, low-density lipoprotein cholesterol and low-density lipoprotein size did not differ significantly after 3 weeks of supplementation. Adding the fish oil to the diet increased the concentration of n-3 very-long-chain polyunsaturated fatty acids and decreased the concentration of n-6 fatty acid and oleic acid in plasma and low-density lipoprotein. Eicosapentaenoic and docosahexaenoic acid supplementation caused elevated values of the high-density lipoprotein cholesterol due to an increment of the high-density lipoprotein 2 fraction and reduced low-density lipoprotein peroxidation rate in vitro. However, we observed an imbalance between oxidizable substrates and antioxidants with an increased lipid peroxidation, whereas the content of reduced glutathione and beta carotene decreased without any variation in vitamin E. Association of antioxidants with n-3 PUFA could prevent lipid peroxidation and enhance the antiatherogenic effects of n-3 polyunsaturated fatty acids. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/10463462/Effects_of_fish_oil_fatty_acids_on_plasma_lipids_and_lipoproteins_and_oxidant_antioxidant_imbalance_in_healthy_subjects_ L2 - https://f1000.com/pubmed/10463462 DB - PRIME DP - Unbound Medicine ER -