Tags

Type your tag names separated by a space and hit enter

Comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial sinusitis.
Clin Ther. 1999 Jul; 21(7):1158-70.CT

Abstract

This double-masked, multicenter, randomized clinical trial compared the efficacy and tolerability of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial maxillary sinusitis. A total of 263 patients with acute bacterial maxillary sinusitis were randomly assigned to receive 10 days of treatment with either cefuroxime axetil 250 mg twice daily (n = 132) or amoxicillin/clavulanate 500/125 mg 3 times daily (n = 131). Patients' responses to treatment were assessed once during treatment (6 to 8 days after the start of treatment), at the end of treatment (1 to 3 days posttreatment), and at follow-up (26 to 30 days after cessation of treatment). Clinical success, defined as cure or improvement, was equivalent in the cefuroxime axetil and amoxicillin/ clavulanate groups at the end-of-treatment and follow-up assessments. Patients in both groups showed improvements in symptoms of acute sinusitis at the during-treatment visit. Treatment with amoxicillin/clavulanate was associated with a significantly higher incidence of drug-related adverse events than treatment with cefuroxime axetil (29% vs 17%), primarily reflecting a higher incidence of gastrointestinal adverse events (23% vs 11%), particularly diarrhea. Two patients in the cefuroxime axetil group and 8 patients in the amoxicillin/clavulanate group withdrew from the study due to adverse events (P = 0.06). These results indicate that cefuroxime axetil 250 mg twice daily is as effective as amoxicillin/clavulanate 500 mg 3 times daily in the treatment of acute sinusitis and produces fewer gastrointestinal adverse events. cefuroxime axetil, amoxicillin/clavulanate, acute sinusitis.

Authors+Show Affiliations

Foothill Family Clinic, Salt Lake City, Utah, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10463514

Citation

Henry, D C., et al. "Comparison of Cefuroxime Axetil and Amoxicillin/clavulanate in the Treatment of Acute Bacterial Sinusitis." Clinical Therapeutics, vol. 21, no. 7, 1999, pp. 1158-70.
Henry DC, Sydnor A, Settipane GA, et al. Comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial sinusitis. Clin Ther. 1999;21(7):1158-70.
Henry, D. C., Sydnor, A., Settipane, G. A., Allen, J., Burroughs, S., Cobb, M. M., & Holley, H. P. (1999). Comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial sinusitis. Clinical Therapeutics, 21(7), 1158-70.
Henry DC, et al. Comparison of Cefuroxime Axetil and Amoxicillin/clavulanate in the Treatment of Acute Bacterial Sinusitis. Clin Ther. 1999;21(7):1158-70. PubMed PMID: 10463514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial sinusitis. AU - Henry,D C, AU - Sydnor,A,Jr AU - Settipane,G A, AU - Allen,J, AU - Burroughs,S, AU - Cobb,M M, AU - Holley,H P,Jr PY - 1999/8/27/pubmed PY - 2001/3/28/medline PY - 1999/8/27/entrez SP - 1158 EP - 70 JF - Clinical therapeutics JO - Clin Ther VL - 21 IS - 7 N2 - This double-masked, multicenter, randomized clinical trial compared the efficacy and tolerability of cefuroxime axetil and amoxicillin/clavulanate in the treatment of acute bacterial maxillary sinusitis. A total of 263 patients with acute bacterial maxillary sinusitis were randomly assigned to receive 10 days of treatment with either cefuroxime axetil 250 mg twice daily (n = 132) or amoxicillin/clavulanate 500/125 mg 3 times daily (n = 131). Patients' responses to treatment were assessed once during treatment (6 to 8 days after the start of treatment), at the end of treatment (1 to 3 days posttreatment), and at follow-up (26 to 30 days after cessation of treatment). Clinical success, defined as cure or improvement, was equivalent in the cefuroxime axetil and amoxicillin/ clavulanate groups at the end-of-treatment and follow-up assessments. Patients in both groups showed improvements in symptoms of acute sinusitis at the during-treatment visit. Treatment with amoxicillin/clavulanate was associated with a significantly higher incidence of drug-related adverse events than treatment with cefuroxime axetil (29% vs 17%), primarily reflecting a higher incidence of gastrointestinal adverse events (23% vs 11%), particularly diarrhea. Two patients in the cefuroxime axetil group and 8 patients in the amoxicillin/clavulanate group withdrew from the study due to adverse events (P = 0.06). These results indicate that cefuroxime axetil 250 mg twice daily is as effective as amoxicillin/clavulanate 500 mg 3 times daily in the treatment of acute sinusitis and produces fewer gastrointestinal adverse events. cefuroxime axetil, amoxicillin/clavulanate, acute sinusitis. SN - 0149-2918 UR - https://www.unboundmedicine.com/medline/citation/10463514/Comparison_of_cefuroxime_axetil_and_amoxicillin/clavulanate_in_the_treatment_of_acute_bacterial_sinusitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0149291800800193 DB - PRIME DP - Unbound Medicine ER -