Heartburn treatment in primary care: randomised, double blind study for 8 weeks.BMJ. 1999 Aug 28; 319(7209):550-3.BMJ
OBJECTIVE
To compare the effects and tolerability of omeprazole and cisapride with that of placebo for control of heartburn in primary care patients.
DESIGN
Randomised, double blind, placebo controlled study.
SETTING
65 primary care practices in Norway.
PARTICIPANTS
483 untreated patients with complaints of heartburn >/=3 days a week, with at most grade 1 reflux oesophagitis.
INTERVENTIONS
Omeprazole 20 mg once daily, cisapride 20 mg twice daily, or placebo for 8 weeks.
MAIN OUTCOME MEASURES
Adequate control of heartburn, defined as </=1 day of the past 7 days with no more than mild heartburn, after 4 weeks of treatment.
RESULTS
In the all patients treated analysis, adequate control of heartburn was achieved in 71% of patients taking omeprazole, 22% taking cisapride, and 18% taking placebo after 4 weeks of treatment (omeprazole v cisapride and placebo, P<0.0001; cisapride v placebo, non-significant). Results were comparable in patients with or without reflux oesophagitis. In patients treated with omeprazole only, symptom control was achieved significantly more often in patients positive for Helicobacter pylori. Antacid use was 2-3 times greater in patients taking cisapride or placebo than in those taking omeprazole. Relief of non-reflux symptoms did not significantly differ between the three groups. Significantly more patients taking cisapride reported adverse events than those taking omeprazole or placebo.
CONCLUSIONS
Omeprazole 20 mg once daily was highly effective in relieving heartburn whereas cisapride 20 mg twice daily was not significantly more effective than placebo.