Tags

Type your tag names separated by a space and hit enter

Long-term haemodynamic effects of octreotide on postprandial splanchnic hyperemia in humans: a placebo-controlled echo-doppler study.
Aliment Pharmacol Ther. 1999 Aug; 13(8):1119-29.AP

Abstract

BACKGROUND

Octreotide is a potent splanchnic hypotensive somatostatin analogue effective in the treatment of acute variceal bleeding.

AIM

To study the effects of octreotide on basal and postprandial splanchnic and systemic haemodynamics, and hormonal changes in humans.

METHODS

Twenty-four healthy volunteers were randomized to receive a liquid meal and either octreotide (OCT, 100 microg bolus) or placebo repeatedly every 4 h for 48 h. Splanchnic (Doppler ultrasound) and systemic haemodynamics (non-invasive cardiac monitoring) were assessed for 2 h on four consecutive days: one control day and after doses 1 (0 h), 7 (24 h) and 13 (48 h).

RESULTS

The maximum postprandial increases in mean blood velocity of the superior mesenteric artery (SMA-Vmean +72%), portal (PBF +52%) and total hepatic blood flow (HBF +50%) observed in the placebo group, were abolished after the first dose of octreotide (SMA-Vmean -23%, P<0.01; PBF -22%, P<0.01; HBF -21%, P<0.01). Postprandial hyperemia was restored at the end of the 48-h study period, but baseline SMA-Vmean (placebo 40+/-12, OCT 29+/-11 cm/s, P<0.05) and PBF (placebo 1200+/-971, OCT 743+/-449 mL/min, P<0.05) remained significantly lower in the octreotide group. The postprandial decrease of systemic vascular resistance and increase of cardiac index were prevented by octreotide for 48 h.

CONCLUSIONS

Repeated 4-hourly bolus injections of octreotide reduce splanchnic blood flow for at least 48 h, but the prevention of food-induced splanchnic hyperemia is short-lasting.

Authors+Show Affiliations

Department of Internal Medicine I, Division of Gastroenterology, University of Lübeck, Lübeck, Germany. ludwigd@medinf.mu-luebeck.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10468691

Citation

Ludwig, D, et al. "Long-term Haemodynamic Effects of Octreotide On Postprandial Splanchnic Hyperemia in Humans: a Placebo-controlled Echo-doppler Study." Alimentary Pharmacology & Therapeutics, vol. 13, no. 8, 1999, pp. 1119-29.
Ludwig D, Terai S, Brüning A, et al. Long-term haemodynamic effects of octreotide on postprandial splanchnic hyperemia in humans: a placebo-controlled echo-doppler study. Aliment Pharmacol Ther. 1999;13(8):1119-29.
Ludwig, D., Terai, S., Brüning, A., & Stange, E. F. (1999). Long-term haemodynamic effects of octreotide on postprandial splanchnic hyperemia in humans: a placebo-controlled echo-doppler study. Alimentary Pharmacology & Therapeutics, 13(8), 1119-29.
Ludwig D, et al. Long-term Haemodynamic Effects of Octreotide On Postprandial Splanchnic Hyperemia in Humans: a Placebo-controlled Echo-doppler Study. Aliment Pharmacol Ther. 1999;13(8):1119-29. PubMed PMID: 10468691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term haemodynamic effects of octreotide on postprandial splanchnic hyperemia in humans: a placebo-controlled echo-doppler study. AU - Ludwig,D, AU - Terai,S, AU - Brüning,A, AU - Stange,E F, PY - 1999/9/1/pubmed PY - 1999/9/1/medline PY - 1999/9/1/entrez SP - 1119 EP - 29 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 13 IS - 8 N2 - BACKGROUND: Octreotide is a potent splanchnic hypotensive somatostatin analogue effective in the treatment of acute variceal bleeding. AIM: To study the effects of octreotide on basal and postprandial splanchnic and systemic haemodynamics, and hormonal changes in humans. METHODS: Twenty-four healthy volunteers were randomized to receive a liquid meal and either octreotide (OCT, 100 microg bolus) or placebo repeatedly every 4 h for 48 h. Splanchnic (Doppler ultrasound) and systemic haemodynamics (non-invasive cardiac monitoring) were assessed for 2 h on four consecutive days: one control day and after doses 1 (0 h), 7 (24 h) and 13 (48 h). RESULTS: The maximum postprandial increases in mean blood velocity of the superior mesenteric artery (SMA-Vmean +72%), portal (PBF +52%) and total hepatic blood flow (HBF +50%) observed in the placebo group, were abolished after the first dose of octreotide (SMA-Vmean -23%, P<0.01; PBF -22%, P<0.01; HBF -21%, P<0.01). Postprandial hyperemia was restored at the end of the 48-h study period, but baseline SMA-Vmean (placebo 40+/-12, OCT 29+/-11 cm/s, P<0.05) and PBF (placebo 1200+/-971, OCT 743+/-449 mL/min, P<0.05) remained significantly lower in the octreotide group. The postprandial decrease of systemic vascular resistance and increase of cardiac index were prevented by octreotide for 48 h. CONCLUSIONS: Repeated 4-hourly bolus injections of octreotide reduce splanchnic blood flow for at least 48 h, but the prevention of food-induced splanchnic hyperemia is short-lasting. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/10468691/Long_term_haemodynamic_effects_of_octreotide_on_postprandial_splanchnic_hyperemia_in_humans:_a_placebo_controlled_echo_doppler_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=1999&amp;volume=13&amp;issue=8&amp;spage=1119 DB - PRIME DP - Unbound Medicine ER -