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Immunohistochemical analysis of prostate-specific antigen does not correlate to other prognostic factors in breast cancer.
Anticancer Res. 1999 Jul-Aug; 19(4A):2563-5.AR

Abstract

BACKGROUND

Prostate-specific antigen (PSA) is found in 30-40% of female breast tumors, as recently described. Diamandis and co-workers could demonstrate that PSA correlate significantly to a relapse-free survival and lower tumor stages in patients with breast cancer using a time-resolved immunofluorometric analysis. The presence of PSA in these tumors seems to reflect a favourable prognostic marker for that disease. The aim of our study was to evaluate the role of PSA as a prognostic factor in breast cancer using an immunohistochemical technique.

MATERIALS AND METHODS

The PSA immunoreactivity of tissues from one-hundred women with malignant breast tumors was correlated to tumor staging, histomorphological tumor type, and biochemical estrogen and progesterone receptor content. Additionally, survival analysis was performed according to Kaplan and Meier.

RESULTS

49% of the tumors revealed positive staining for PSA. No significant correlation between PSA and the other parameters, or the mean survival time (PSA pos.: 5.3 years, PSA neg.: 5.4 years) could be demonstrated.

CONCLUSIONS

As there were no significant correlations between PSA and other prognostic markers, PSA detected by immunohistochemistry seems not to be helpful in prognostic evaluation of breast cancer.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Technology, Aachen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10470195

Citation

Heyl, W, et al. "Immunohistochemical Analysis of Prostate-specific Antigen Does Not Correlate to Other Prognostic Factors in Breast Cancer." Anticancer Research, vol. 19, no. 4A, 1999, pp. 2563-5.
Heyl W, Wolff JM, Biesterfeld S, et al. Immunohistochemical analysis of prostate-specific antigen does not correlate to other prognostic factors in breast cancer. Anticancer Res. 1999;19(4A):2563-5.
Heyl, W., Wolff, J. M., Biesterfeld, S., Schröder, W., Zitzelsberger, D., Jakse, G., & Rath, W. (1999). Immunohistochemical analysis of prostate-specific antigen does not correlate to other prognostic factors in breast cancer. Anticancer Research, 19(4A), 2563-5.
Heyl W, et al. Immunohistochemical Analysis of Prostate-specific Antigen Does Not Correlate to Other Prognostic Factors in Breast Cancer. Anticancer Res. 1999 Jul-Aug;19(4A):2563-5. PubMed PMID: 10470195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical analysis of prostate-specific antigen does not correlate to other prognostic factors in breast cancer. AU - Heyl,W, AU - Wolff,J M, AU - Biesterfeld,S, AU - Schröder,W, AU - Zitzelsberger,D, AU - Jakse,G, AU - Rath,W, PY - 1999/9/2/pubmed PY - 1999/9/2/medline PY - 1999/9/2/entrez SP - 2563 EP - 5 JF - Anticancer research JO - Anticancer Res VL - 19 IS - 4A N2 - BACKGROUND: Prostate-specific antigen (PSA) is found in 30-40% of female breast tumors, as recently described. Diamandis and co-workers could demonstrate that PSA correlate significantly to a relapse-free survival and lower tumor stages in patients with breast cancer using a time-resolved immunofluorometric analysis. The presence of PSA in these tumors seems to reflect a favourable prognostic marker for that disease. The aim of our study was to evaluate the role of PSA as a prognostic factor in breast cancer using an immunohistochemical technique. MATERIALS AND METHODS: The PSA immunoreactivity of tissues from one-hundred women with malignant breast tumors was correlated to tumor staging, histomorphological tumor type, and biochemical estrogen and progesterone receptor content. Additionally, survival analysis was performed according to Kaplan and Meier. RESULTS: 49% of the tumors revealed positive staining for PSA. No significant correlation between PSA and the other parameters, or the mean survival time (PSA pos.: 5.3 years, PSA neg.: 5.4 years) could be demonstrated. CONCLUSIONS: As there were no significant correlations between PSA and other prognostic markers, PSA detected by immunohistochemistry seems not to be helpful in prognostic evaluation of breast cancer. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/10470195/Immunohistochemical_analysis_of_prostate_specific_antigen_does_not_correlate_to_other_prognostic_factors_in_breast_cancer_ L2 - http://www.diseaseinfosearch.org/result/9175 DB - PRIME DP - Unbound Medicine ER -