Tags

Type your tag names separated by a space and hit enter

A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis.
Am J Respir Crit Care Med. 1999 Sep; 160(3):899-905.AJ

Abstract

This study aimed to investigate whether there was a difference in outcome related to histologic pattern in cryptogenic fibrosing alveolitis (CFA) and to see whether there were correlations between clinical and radiologic findings and histology. One hundred thirteen lung biopsies from consecutive patients taken for the diagnosis of diffuse lung disease were reviewed and reclassified using the Katzenstein and Myers criteria for interstitial pneumonias. Patients lacking full investigational data at presentation and those with conditions predisposing to lung fibrosis were excluded, leaving 15 patients diagnosed with nonspecific interstitial pneumonia (NSIP) and 15 with usual interstitial pneumonia (UIP). Clinical and radiologic findings at presentation and serial lung function information and survival status in November 1998 were compared for the two groups. Survival was found to be significantly greater in the NSIP group compared with the UIP group (p < 0.001). This could not be explained by differences in treatment. Patients with UIP showed a progressive deterioration in lung function whereas those with NSIP remained stable. CT scans of patients with UIP showed more fibrosis than those of patients with NSIP (p < 0.011). A histologic diagnosis of NSIP is associated with a better prognosis than UIP. This subclassification of CFA is clinically useful.

Authors+Show Affiliations

Interstitial Lung Disease Unit and Departments of Histopathology and Radiology, Royal Brompton Hospital, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

10471616

Citation

Daniil, Z D., et al. "A Histologic Pattern of Nonspecific Interstitial Pneumonia Is Associated With a Better Prognosis Than Usual Interstitial Pneumonia in Patients With Cryptogenic Fibrosing Alveolitis." American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 3, 1999, pp. 899-905.
Daniil ZD, Gilchrist FC, Nicholson AG, et al. A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med. 1999;160(3):899-905.
Daniil, Z. D., Gilchrist, F. C., Nicholson, A. G., Hansell, D. M., Harris, J., Colby, T. V., & du Bois, R. M. (1999). A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis. American Journal of Respiratory and Critical Care Medicine, 160(3), 899-905.
Daniil ZD, et al. A Histologic Pattern of Nonspecific Interstitial Pneumonia Is Associated With a Better Prognosis Than Usual Interstitial Pneumonia in Patients With Cryptogenic Fibrosing Alveolitis. Am J Respir Crit Care Med. 1999;160(3):899-905. PubMed PMID: 10471616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis. AU - Daniil,Z D, AU - Gilchrist,F C, AU - Nicholson,A G, AU - Hansell,D M, AU - Harris,J, AU - Colby,T V, AU - du Bois,R M, PY - 1999/9/3/pubmed PY - 1999/9/3/medline PY - 1999/9/3/entrez SP - 899 EP - 905 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 160 IS - 3 N2 - This study aimed to investigate whether there was a difference in outcome related to histologic pattern in cryptogenic fibrosing alveolitis (CFA) and to see whether there were correlations between clinical and radiologic findings and histology. One hundred thirteen lung biopsies from consecutive patients taken for the diagnosis of diffuse lung disease were reviewed and reclassified using the Katzenstein and Myers criteria for interstitial pneumonias. Patients lacking full investigational data at presentation and those with conditions predisposing to lung fibrosis were excluded, leaving 15 patients diagnosed with nonspecific interstitial pneumonia (NSIP) and 15 with usual interstitial pneumonia (UIP). Clinical and radiologic findings at presentation and serial lung function information and survival status in November 1998 were compared for the two groups. Survival was found to be significantly greater in the NSIP group compared with the UIP group (p < 0.001). This could not be explained by differences in treatment. Patients with UIP showed a progressive deterioration in lung function whereas those with NSIP remained stable. CT scans of patients with UIP showed more fibrosis than those of patients with NSIP (p < 0.011). A histologic diagnosis of NSIP is associated with a better prognosis than UIP. This subclassification of CFA is clinically useful. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/10471616/A_histologic_pattern_of_nonspecific_interstitial_pneumonia_is_associated_with_a_better_prognosis_than_usual_interstitial_pneumonia_in_patients_with_cryptogenic_fibrosing_alveolitis_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm.160.3.9903021?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -