Tags

Type your tag names separated by a space and hit enter

Elastosis and fragmentation of fibers of the elastic system in fatal asthma.
Am J Respir Crit Care Med. 1999 Sep; 160(3):968-75.AJ

Abstract

Fibers of the elastic system (FES) are important in regulating airway patency and lung elastic recoil. Their possible role in modulating bronchoconstriction is not fully understood. Chronic inflammation and mechanical stretching present in asthma could lead to conformational alterations in the FES, participating in the mechanism of airway remodeling observed in this disease. In airway mucosa, two layers of FES are discernible: one superficial network, attached to the basement membrane, and a deeper network, lying close to the airway smooth muscle. Using image analysis and conventional morphometry, we analyzed airway content of FES in central and peripheral airways in 31 cases of fatal asthma and in 10 control lungs. Slides were stained using the oxidized resorcin-fuchsin method. Optical analysis revealed fragmentation of the FES in the superficial network of central asthmatic airways. Morphometry showed the presence of elastosis in central asthmatic airways when the entire thickness of the mucosa was considered. In the superficial network elastic fiber content was significantly decreased. These results indicate that FES participate in airway remodeling in asthma. We also suggest that disrupture of fiber attachments at the basement membrane in the superficial layer could impair the mechanism of airway recoil in asthmatic patients.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Mauad T
Department of Pathology, Faculty of Medicine, São Paulo University, São Paulo, Brazil. tmauad@usp.br
Xavier AC
No affiliation info available
Saldiva PH
No affiliation info available
Dolhnikoff M
No affiliation info available

MeSH

AdolescentAdultAsthmaBronchiElastic TissueFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedStaining and Labeling

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10471626

Citation

Mauad, T, et al. "Elastosis and Fragmentation of Fibers of the Elastic System in Fatal Asthma." American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 3, 1999, pp. 968-75.
Mauad T, Xavier AC, Saldiva PH, et al. Elastosis and fragmentation of fibers of the elastic system in fatal asthma. Am J Respir Crit Care Med. 1999;160(3):968-75.
Mauad, T., Xavier, A. C., Saldiva, P. H., & Dolhnikoff, M. (1999). Elastosis and fragmentation of fibers of the elastic system in fatal asthma. American Journal of Respiratory and Critical Care Medicine, 160(3), 968-75.
Mauad T, et al. Elastosis and Fragmentation of Fibers of the Elastic System in Fatal Asthma. Am J Respir Crit Care Med. 1999;160(3):968-75. PubMed PMID: 10471626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elastosis and fragmentation of fibers of the elastic system in fatal asthma. AU - Mauad,T, AU - Xavier,A C, AU - Saldiva,P H, AU - Dolhnikoff,M, PY - 1999/9/3/pubmed PY - 1999/9/3/medline PY - 1999/9/3/entrez SP - 968 EP - 75 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 160 IS - 3 N2 - Fibers of the elastic system (FES) are important in regulating airway patency and lung elastic recoil. Their possible role in modulating bronchoconstriction is not fully understood. Chronic inflammation and mechanical stretching present in asthma could lead to conformational alterations in the FES, participating in the mechanism of airway remodeling observed in this disease. In airway mucosa, two layers of FES are discernible: one superficial network, attached to the basement membrane, and a deeper network, lying close to the airway smooth muscle. Using image analysis and conventional morphometry, we analyzed airway content of FES in central and peripheral airways in 31 cases of fatal asthma and in 10 control lungs. Slides were stained using the oxidized resorcin-fuchsin method. Optical analysis revealed fragmentation of the FES in the superficial network of central asthmatic airways. Morphometry showed the presence of elastosis in central asthmatic airways when the entire thickness of the mucosa was considered. In the superficial network elastic fiber content was significantly decreased. These results indicate that FES participate in airway remodeling in asthma. We also suggest that disrupture of fiber attachments at the basement membrane in the superficial layer could impair the mechanism of airway recoil in asthmatic patients. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/10471626/Elastosis_and_fragmentation_of_fibers_of_the_elastic_system_in_fatal_asthma_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm.160.3.9809088?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -