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The postwar hospitalization experience of Gulf War Veterans possibly exposed to chemical munitions destruction at Khamisiyah, Iraq.
Am J Epidemiol. 1999 Sep 01; 150(5):532-40.AJ

Abstract

Using Department of Defense hospital data, the authors examined the postwar hospitalization experience from March 1991 through September 1995 of US Gulf War veterans who were near Khamisiyah, Iraq, during nerve agent munition destruction in March 1991. Multiple sources of meteorologic, munition, and toxicology data were used to circumscribe geographic areas of low level, vaporized nerve agent for 4 days after the destruction. Plume estimates were overlaid on military unit positions, and exposure was estimated for the 349,291 US Army Gulf War veterans. Exposure was classified as not exposed (n = 224,804), uncertain low dose exposure (n = 75,717), and specific estimated subclinical exposure (n = 48,770) categorized into three groups for dose-response evaluation. Using Cox proportional hazard modeling, the authors compared the postwar experiences of these exposure groups for hospitalization due to any cause, for diagnoses in 15 unique categories, and for specific diagnoses an expert panel proposed as most likely to reflect latent disease from such subclinical exposure. There was little evidence that veterans possibly exposed to the nerve agent plumes experienced unusual postwar morbidity. While there were several differences in hospitalization risk, none of the models suggested a dose-response relation or neurologic sequelae. These data, having a number of limitations, do not support the hypothesis that Gulf War veterans are suffering postwar morbidity from subclinical nerve agent exposure.

Authors+Show Affiliations

Department of Health Sciences and Epidemiology, Naval Health Research Center, San Diego, CA 92186-5122, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10472954

Citation

Gray, G C., et al. "The Postwar Hospitalization Experience of Gulf War Veterans Possibly Exposed to Chemical Munitions Destruction at Khamisiyah, Iraq." American Journal of Epidemiology, vol. 150, no. 5, 1999, pp. 532-40.
Gray GC, Smith TC, Knoke JD, et al. The postwar hospitalization experience of Gulf War Veterans possibly exposed to chemical munitions destruction at Khamisiyah, Iraq. Am J Epidemiol. 1999;150(5):532-40.
Gray, G. C., Smith, T. C., Knoke, J. D., & Heller, J. M. (1999). The postwar hospitalization experience of Gulf War Veterans possibly exposed to chemical munitions destruction at Khamisiyah, Iraq. American Journal of Epidemiology, 150(5), 532-40.
Gray GC, et al. The Postwar Hospitalization Experience of Gulf War Veterans Possibly Exposed to Chemical Munitions Destruction at Khamisiyah, Iraq. Am J Epidemiol. 1999 Sep 1;150(5):532-40. PubMed PMID: 10472954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The postwar hospitalization experience of Gulf War Veterans possibly exposed to chemical munitions destruction at Khamisiyah, Iraq. AU - Gray,G C, AU - Smith,T C, AU - Knoke,J D, AU - Heller,J M, PY - 1999/9/3/pubmed PY - 1999/9/3/medline PY - 1999/9/3/entrez SP - 532 EP - 40 JF - American journal of epidemiology JO - Am J Epidemiol VL - 150 IS - 5 N2 - Using Department of Defense hospital data, the authors examined the postwar hospitalization experience from March 1991 through September 1995 of US Gulf War veterans who were near Khamisiyah, Iraq, during nerve agent munition destruction in March 1991. Multiple sources of meteorologic, munition, and toxicology data were used to circumscribe geographic areas of low level, vaporized nerve agent for 4 days after the destruction. Plume estimates were overlaid on military unit positions, and exposure was estimated for the 349,291 US Army Gulf War veterans. Exposure was classified as not exposed (n = 224,804), uncertain low dose exposure (n = 75,717), and specific estimated subclinical exposure (n = 48,770) categorized into three groups for dose-response evaluation. Using Cox proportional hazard modeling, the authors compared the postwar experiences of these exposure groups for hospitalization due to any cause, for diagnoses in 15 unique categories, and for specific diagnoses an expert panel proposed as most likely to reflect latent disease from such subclinical exposure. There was little evidence that veterans possibly exposed to the nerve agent plumes experienced unusual postwar morbidity. While there were several differences in hospitalization risk, none of the models suggested a dose-response relation or neurologic sequelae. These data, having a number of limitations, do not support the hypothesis that Gulf War veterans are suffering postwar morbidity from subclinical nerve agent exposure. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/10472954/The_postwar_hospitalization_experience_of_Gulf_War_Veterans_possibly_exposed_to_chemical_munitions_destruction_at_Khamisiyah_Iraq_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a010043 DB - PRIME DP - Unbound Medicine ER -