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Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men.

Abstract

BACKGROUND

The age-related decline in maximal oxygen consumption is attenuated by habitual aerobic exercise. However, the relative effects of training on central and peripheral responses to exercise in older subjects are not known. The present study assessed the contribution of central and peripheral responses to the age-associated decline in peak oxygen consumption and compared the effect of exercise training in healthy older and younger subjects.

METHODS AND RESULTS

Ten older and 13 younger men underwent invasive measurement of central and peripheral cardiovascular responses during an upright, staged cycle exercise test before and after a 3-month period of exercise training with cycle ergometry. At baseline, cardiac output and AV oxygen difference during exercise were significantly lower in older subjects. With training, the older and younger groups increased maximal oxygen consumption by 17.8% and 20.2%, respectively. Peak cardiac output was unchanged in both groups. Systemic AV oxygen difference increased 14.4% in the older group and 14.3% in the younger group and accounted for changes in peak oxygen consumption. Peak leg blood flow increased by 50% in older subjects, whereas the younger group showed no significant change. There was no change in peak leg oxygen extraction in the older group, but in the younger group, leg AV oxygen difference increased by 15.4%.

CONCLUSIONS

These findings suggest that the age-related decline in maximal oxygen consumption results from a reversible deconditioning effect on the distribution of cardiac output to exercising muscle and an age-related reduction in cardiac output reserve.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Divisions of Cardiology and Geriatrics, Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA.

    , , ,

    Source

    Circulation 100:10 1999 Sep 07 pg 1085-94

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Aging
    Blood Circulation
    Cardiac Output
    Exercise
    Hemodynamics
    Humans
    Leg
    Male
    Middle Aged
    Oxygen
    Oxygen Consumption
    Physical Education and Training
    Reference Values
    Regional Blood Flow

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10477534

    Citation

    Beere, P A., et al. "Aerobic Exercise Training Can Reverse Age-related Peripheral Circulatory Changes in Healthy Older Men." Circulation, vol. 100, no. 10, 1999, pp. 1085-94.
    Beere PA, Russell SD, Morey MC, et al. Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men. Circulation. 1999;100(10):1085-94.
    Beere, P. A., Russell, S. D., Morey, M. C., Kitzman, D. W., & Higginbotham, M. B. (1999). Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men. Circulation, 100(10), pp. 1085-94.
    Beere PA, et al. Aerobic Exercise Training Can Reverse Age-related Peripheral Circulatory Changes in Healthy Older Men. Circulation. 1999 Sep 7;100(10):1085-94. PubMed PMID: 10477534.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men. AU - Beere,P A, AU - Russell,S D, AU - Morey,M C, AU - Kitzman,D W, AU - Higginbotham,M B, PY - 1999/9/8/pubmed PY - 1999/9/8/medline PY - 1999/9/8/entrez SP - 1085 EP - 94 JF - Circulation JO - Circulation VL - 100 IS - 10 N2 - BACKGROUND: The age-related decline in maximal oxygen consumption is attenuated by habitual aerobic exercise. However, the relative effects of training on central and peripheral responses to exercise in older subjects are not known. The present study assessed the contribution of central and peripheral responses to the age-associated decline in peak oxygen consumption and compared the effect of exercise training in healthy older and younger subjects. METHODS AND RESULTS: Ten older and 13 younger men underwent invasive measurement of central and peripheral cardiovascular responses during an upright, staged cycle exercise test before and after a 3-month period of exercise training with cycle ergometry. At baseline, cardiac output and AV oxygen difference during exercise were significantly lower in older subjects. With training, the older and younger groups increased maximal oxygen consumption by 17.8% and 20.2%, respectively. Peak cardiac output was unchanged in both groups. Systemic AV oxygen difference increased 14.4% in the older group and 14.3% in the younger group and accounted for changes in peak oxygen consumption. Peak leg blood flow increased by 50% in older subjects, whereas the younger group showed no significant change. There was no change in peak leg oxygen extraction in the older group, but in the younger group, leg AV oxygen difference increased by 15.4%. CONCLUSIONS: These findings suggest that the age-related decline in maximal oxygen consumption results from a reversible deconditioning effect on the distribution of cardiac output to exercising muscle and an age-related reduction in cardiac output reserve. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/10477534/Aerobic_exercise_training_can_reverse_age_related_peripheral_circulatory_changes_in_healthy_older_men_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10477534.ui DB - PRIME DP - Unbound Medicine ER -