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Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine.
Food Chem Toxicol. 1999 Jun; 37(6):569-79.FC

Abstract

The antimutagenic properties of various tea extracts (green tea, pauchong tea, oolong tea and black tea) and their components including (-)-epigallocatechin-3-gallate (EGCG), gallic acid and caffeine were examined by the Ames test. The antimutagenic activity of the green tea extract against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), folpet and monocrotophos was greater than those of pouchong, oolong and black tea extracts. The antimutagenic effects of tea extracts against 2-acetylaminofluorene (AAF) decreased as follows: oolong tea > pauchong tea > black tea > green tea. Furthermore, black tea showed a greater antimutagenic activity against benzo[a]pyrene (BP). The pauchong tea showed a stronger inhibitory effect against 9-aminoacridine (9AA) and aflatoxin B1 (AFB1) than other tea extracts. EGCG markedly suppressed the direct-acting mutagenicity of MNNG, N-nitroso-N-methylurea (MNU), captan, and folpet which were alkylating agents and fungicides. Similarly, gallic acid, the major component of black tea strongly inhibited the mutagenicity of 9AA, and moderately inhibited the mutagenicity of MNNG and folpet. The caffeine was less active. EGCG and gallic acid perhaps could act as nucleophiles to scavenge the electrophilic mutagens. Taken together, these results suggest that formation of different metabolites during various stages of tea fermentation may affect antimutagenic potencies against different types of chemical mutagens.

Authors+Show Affiliations

Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10478825

Citation

Hour, T C., et al. "Inhibition of Eleven Mutagens By Various Tea Extracts, (-)epigallocatechin-3-gallate, Gallic Acid and Caffeine." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 37, no. 6, 1999, pp. 569-79.
Hour TC, Liang YC, Chu IS, et al. Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine. Food Chem Toxicol. 1999;37(6):569-79.
Hour, T. C., Liang, Y. C., Chu, I. S., & Lin, J. K. (1999). Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 37(6), 569-79.
Hour TC, et al. Inhibition of Eleven Mutagens By Various Tea Extracts, (-)epigallocatechin-3-gallate, Gallic Acid and Caffeine. Food Chem Toxicol. 1999;37(6):569-79. PubMed PMID: 10478825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine. AU - Hour,T C, AU - Liang,Y C, AU - Chu,I S, AU - Lin,J K, PY - 1999/9/9/pubmed PY - 1999/9/9/medline PY - 1999/9/9/entrez SP - 569 EP - 79 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 37 IS - 6 N2 - The antimutagenic properties of various tea extracts (green tea, pauchong tea, oolong tea and black tea) and their components including (-)-epigallocatechin-3-gallate (EGCG), gallic acid and caffeine were examined by the Ames test. The antimutagenic activity of the green tea extract against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), folpet and monocrotophos was greater than those of pouchong, oolong and black tea extracts. The antimutagenic effects of tea extracts against 2-acetylaminofluorene (AAF) decreased as follows: oolong tea > pauchong tea > black tea > green tea. Furthermore, black tea showed a greater antimutagenic activity against benzo[a]pyrene (BP). The pauchong tea showed a stronger inhibitory effect against 9-aminoacridine (9AA) and aflatoxin B1 (AFB1) than other tea extracts. EGCG markedly suppressed the direct-acting mutagenicity of MNNG, N-nitroso-N-methylurea (MNU), captan, and folpet which were alkylating agents and fungicides. Similarly, gallic acid, the major component of black tea strongly inhibited the mutagenicity of 9AA, and moderately inhibited the mutagenicity of MNNG and folpet. The caffeine was less active. EGCG and gallic acid perhaps could act as nucleophiles to scavenge the electrophilic mutagens. Taken together, these results suggest that formation of different metabolites during various stages of tea fermentation may affect antimutagenic potencies against different types of chemical mutagens. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/10478825/Inhibition_of_eleven_mutagens_by_various_tea_extracts____epigallocatechin_3_gallate_gallic_acid_and_caffeine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278691599000319 DB - PRIME DP - Unbound Medicine ER -