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Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.
J Neurosci. 1999 Sep 15; 19(18):8114-21.JN

Abstract

Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress that may be ameliorated by antioxidants. Our previous study had shown that rats given dietary supplements of fruit and vegetable extracts with high antioxidant activity for 8 months beginning at 6 months of age retarded age-related declines in neuronal and cognitive function. The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance. These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.

Authors+Show Affiliations

United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

10479711

Citation

Joseph, J A., et al. "Reversals of Age-related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits With Blueberry, Spinach, or Strawberry Dietary Supplementation." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 19, no. 18, 1999, pp. 8114-21.
Joseph JA, Shukitt-Hale B, Denisova NA, et al. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci. 1999;19(18):8114-21.
Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C. (1999). Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 19(18), 8114-21.
Joseph JA, et al. Reversals of Age-related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits With Blueberry, Spinach, or Strawberry Dietary Supplementation. J Neurosci. 1999 Sep 15;19(18):8114-21. PubMed PMID: 10479711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. AU - Joseph,J A, AU - Shukitt-Hale,B, AU - Denisova,N A, AU - Bielinski,D, AU - Martin,A, AU - McEwen,J J, AU - Bickford,P C, PY - 1999/9/10/pubmed PY - 1999/9/10/medline PY - 1999/9/10/entrez SP - 8114 EP - 21 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J Neurosci VL - 19 IS - 18 N2 - Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress that may be ameliorated by antioxidants. Our previous study had shown that rats given dietary supplements of fruit and vegetable extracts with high antioxidant activity for 8 months beginning at 6 months of age retarded age-related declines in neuronal and cognitive function. The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance. These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/10479711/Reversals_of_age_related_declines_in_neuronal_signal_transduction_cognitive_and_motor_behavioral_deficits_with_blueberry_spinach_or_strawberry_dietary_supplementation_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=10479711 DB - PRIME DP - Unbound Medicine ER -