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Depression in patients with Parkinson's disease.
Int J Geriatr Psychiatry. 1999 Sep; 14(9):711-8.IJ

Abstract

Parkinson's disease (PD) is a disabling neurodegenerative condition commonly complicated by the existence of comorbid depression. The prevalence rates of depression in this patient group have been reported to be as high as 40%. Currently, depression in PD is undertreated; there have been few controlled clinical trials of antidepressants in this patient group. Patients with PD are usually elderly and often administered a range of medication, therefore the choice of antidepressant must be undertaken with care. Tricyclic antidepressants (TCAs) have been studied in patients with PD and comorbid depression; however, the risk of anticholinergic side-effects means that their use is largely avoided. Selective serotonin reuptake inhibitors have comparable efficacy to the TCAs and a better tolerability profile in patients with depression; they are rapidly being considered as first-line therapy for PD patients with depression. Clinical studies in this patient group are warranted. This article reviews the characteristics of comorbid depression in patients with PD and discusses the treatment options available.

Authors+Show Affiliations

UCLA Medical Centre, California, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10479741

Citation

Cummings, J L., and D L. Masterman. "Depression in Patients With Parkinson's Disease." International Journal of Geriatric Psychiatry, vol. 14, no. 9, 1999, pp. 711-8.
Cummings JL, Masterman DL. Depression in patients with Parkinson's disease. Int J Geriatr Psychiatry. 1999;14(9):711-8.
Cummings, J. L., & Masterman, D. L. (1999). Depression in patients with Parkinson's disease. International Journal of Geriatric Psychiatry, 14(9), 711-8.
Cummings JL, Masterman DL. Depression in Patients With Parkinson's Disease. Int J Geriatr Psychiatry. 1999;14(9):711-8. PubMed PMID: 10479741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression in patients with Parkinson's disease. AU - Cummings,J L, AU - Masterman,D L, PY - 1999/9/10/pubmed PY - 1999/9/10/medline PY - 1999/9/10/entrez SP - 711 EP - 8 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 14 IS - 9 N2 - Parkinson's disease (PD) is a disabling neurodegenerative condition commonly complicated by the existence of comorbid depression. The prevalence rates of depression in this patient group have been reported to be as high as 40%. Currently, depression in PD is undertreated; there have been few controlled clinical trials of antidepressants in this patient group. Patients with PD are usually elderly and often administered a range of medication, therefore the choice of antidepressant must be undertaken with care. Tricyclic antidepressants (TCAs) have been studied in patients with PD and comorbid depression; however, the risk of anticholinergic side-effects means that their use is largely avoided. Selective serotonin reuptake inhibitors have comparable efficacy to the TCAs and a better tolerability profile in patients with depression; they are rapidly being considered as first-line therapy for PD patients with depression. Clinical studies in this patient group are warranted. This article reviews the characteristics of comorbid depression in patients with PD and discusses the treatment options available. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/10479741/Depression_in_patients_with_Parkinson's_disease_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -