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Glomerular filtration rate, urinary albumin excretion rate, and blood pressure changes in normoalbuminuric normotensive type 1 diabetic patients: an 8-year follow-up study.
Diabetes Care. 1999 Sep; 22(9):1512-6.DC

Abstract

OBJECTIVE

To analyze the changes in glomerular filtration rate (GFR), urinary albumin excretion rate (UAER), and blood pressure (BP) levels in a cohort of normoalbuminuric and normotensive type 1 diabetic patients.

RESEARCH DESIGN AND METHODS

This is an 8.4+/-2.1-year prospective study of 33 normotensive normoalbuminuric (24-h UAER <20 microg/min) type 1 diabetic patients. UAER (radioimmunoassay), GFR (51Cr-EDTA single-injection technique), and GHb (ion-exchange chromatography) were measured at baseline and at 1- to 2-year intervals.

RESULTS

The GFR decreased (137.6+/-16.5 to 116.4+/-21.3 ml x min(-1) x 1.73 m(-2) P < 0.05) during the follow-up period. GFR reduction (-0.20+/-0.29 ml x min(-1) x month(-1); P < 0.05) was associated with baseline GFR and mean GHb (R2 = 0.30; beta = 0.072; F = 6.54; P = 0.004). UAER was higher at the end of the study (3.7-7.1 microg/min; P = 0.017). Microalbuminuria was observed in two patients, while macroalbuminuria was observed in one. No changes in UAER were observed when these three patients were excluded from the analysis. Mean blood pressure (MBP) increased during the study (85.8+/-9.7 to 99.6+/-11.6 mmHg; P < 0.001). MBP at the end of the study was associated with age and GFR at baseline (R2 = 0.39; beta = 0.074; F = 9.64; P = 0.001).

CONCLUSIONS

In this cohort of normoalbuminuric normotensive type 1 diabetic patients, GFR decreased and BP levels increased during the follow-up period. The predictors for the GFR change were baseline GFR level and metabolic control. For end-of-study MBP, the predictor was baseline GFR level.

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Authors+Show Affiliations

Caramori ML
Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Gross JL
No affiliation info available
Pecis M
No affiliation info available
de Azevedo MJ
No affiliation info available

MeSH

AdultAlbuminuriaBlood PressureBrazilDiabetes Mellitus, Type 1Follow-Up StudiesGlomerular Filtration RateHumansHypertensionIncidenceMaleMiddle AgedProspective Studies

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10480518

Citation

Caramori, M L., et al. "Glomerular Filtration Rate, Urinary Albumin Excretion Rate, and Blood Pressure Changes in Normoalbuminuric Normotensive Type 1 Diabetic Patients: an 8-year Follow-up Study." Diabetes Care, vol. 22, no. 9, 1999, pp. 1512-6.
Caramori ML, Gross JL, Pecis M, et al. Glomerular filtration rate, urinary albumin excretion rate, and blood pressure changes in normoalbuminuric normotensive type 1 diabetic patients: an 8-year follow-up study. Diabetes Care. 1999;22(9):1512-6.
Caramori, M. L., Gross, J. L., Pecis, M., & de Azevedo, M. J. (1999). Glomerular filtration rate, urinary albumin excretion rate, and blood pressure changes in normoalbuminuric normotensive type 1 diabetic patients: an 8-year follow-up study. Diabetes Care, 22(9), 1512-6.
Caramori ML, et al. Glomerular Filtration Rate, Urinary Albumin Excretion Rate, and Blood Pressure Changes in Normoalbuminuric Normotensive Type 1 Diabetic Patients: an 8-year Follow-up Study. Diabetes Care. 1999;22(9):1512-6. PubMed PMID: 10480518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glomerular filtration rate, urinary albumin excretion rate, and blood pressure changes in normoalbuminuric normotensive type 1 diabetic patients: an 8-year follow-up study. AU - Caramori,M L, AU - Gross,J L, AU - Pecis,M, AU - de Azevedo,M J, PY - 1999/9/10/pubmed PY - 1999/9/10/medline PY - 1999/9/10/entrez SP - 1512 EP - 6 JF - Diabetes care JO - Diabetes Care VL - 22 IS - 9 N2 - OBJECTIVE: To analyze the changes in glomerular filtration rate (GFR), urinary albumin excretion rate (UAER), and blood pressure (BP) levels in a cohort of normoalbuminuric and normotensive type 1 diabetic patients. RESEARCH DESIGN AND METHODS: This is an 8.4+/-2.1-year prospective study of 33 normotensive normoalbuminuric (24-h UAER <20 microg/min) type 1 diabetic patients. UAER (radioimmunoassay), GFR (51Cr-EDTA single-injection technique), and GHb (ion-exchange chromatography) were measured at baseline and at 1- to 2-year intervals. RESULTS: The GFR decreased (137.6+/-16.5 to 116.4+/-21.3 ml x min(-1) x 1.73 m(-2) P < 0.05) during the follow-up period. GFR reduction (-0.20+/-0.29 ml x min(-1) x month(-1); P < 0.05) was associated with baseline GFR and mean GHb (R2 = 0.30; beta = 0.072; F = 6.54; P = 0.004). UAER was higher at the end of the study (3.7-7.1 microg/min; P = 0.017). Microalbuminuria was observed in two patients, while macroalbuminuria was observed in one. No changes in UAER were observed when these three patients were excluded from the analysis. Mean blood pressure (MBP) increased during the study (85.8+/-9.7 to 99.6+/-11.6 mmHg; P < 0.001). MBP at the end of the study was associated with age and GFR at baseline (R2 = 0.39; beta = 0.074; F = 9.64; P = 0.001). CONCLUSIONS: In this cohort of normoalbuminuric normotensive type 1 diabetic patients, GFR decreased and BP levels increased during the follow-up period. The predictors for the GFR change were baseline GFR level and metabolic control. For end-of-study MBP, the predictor was baseline GFR level. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/10480518/Glomerular_filtration_rate_urinary_albumin_excretion_rate_and_blood_pressure_changes_in_normoalbuminuric_normotensive_type_1_diabetic_patients:_an_8_year_follow_up_study_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=10480518 DB - PRIME DP - Unbound Medicine ER -