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The small intestine can both absorb and glucuronidate luminal flavonoids.
FEBS Lett. 1999 Sep 17; 458(2):224-30.FL

Abstract

We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP-glucuronyl transferase in the jejunum. In contrast, quercetin-3-glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%+/-4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B-ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%+/-10.1) are detected on absorption through both the jejunum and ileum.

Authors+Show Affiliations

International Antioxidant Research Centre, Guy's King's and St. Thomas's School of Biomedical Sciences, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10481070

Citation

Spencer, J P., et al. "The Small Intestine Can Both Absorb and Glucuronidate Luminal Flavonoids." FEBS Letters, vol. 458, no. 2, 1999, pp. 224-30.
Spencer JP, Chowrimootoo G, Choudhury R, et al. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett. 1999;458(2):224-30.
Spencer, J. P., Chowrimootoo, G., Choudhury, R., Debnam, E. S., Srai, S. K., & Rice-Evans, C. (1999). The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Letters, 458(2), 224-30.
Spencer JP, et al. The Small Intestine Can Both Absorb and Glucuronidate Luminal Flavonoids. FEBS Lett. 1999 Sep 17;458(2):224-30. PubMed PMID: 10481070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The small intestine can both absorb and glucuronidate luminal flavonoids. AU - Spencer,J P, AU - Chowrimootoo,G, AU - Choudhury,R, AU - Debnam,E S, AU - Srai,S K, AU - Rice-Evans,C, PY - 1999/9/11/pubmed PY - 1999/9/11/medline PY - 1999/9/11/entrez SP - 224 EP - 30 JF - FEBS letters JO - FEBS Lett VL - 458 IS - 2 N2 - We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP-glucuronyl transferase in the jejunum. In contrast, quercetin-3-glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%+/-4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B-ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%+/-10.1) are detected on absorption through both the jejunum and ileum. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/10481070/The_small_intestine_can_both_absorb_and_glucuronidate_luminal_flavonoids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-5793(99)01160-6 DB - PRIME DP - Unbound Medicine ER -