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Genetic testing in hereditary colorectal cancer: indications and procedures.
Am J Gastroenterol. 1999 Sep; 94(9):2344-56.AJ

Abstract

Approximately 25% of colorectal cancers occur in younger individuals or those with a personal or family history of the disease, suggesting a heritable susceptibility. The minority of these cases are accounted for by one of the well-described hereditary colorectal cancer syndromes, familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). The recent identification and cloning of the genes responsible for FAP and HNPCC, along with other colon cancer susceptibility genes, has led to the wide-spread availability of genetic testing for hereditary colorectal cancer. Genetic testing raises clinical, ethical, legal, and psychosocial questions that must urgently be discussed. This review highlights areas of knowledge and uncertainty about genetic predisposition testing for colorectal cancer and provides clinicians with practical recommendations regarding the proper indications and procedures for this testing.

Authors+Show Affiliations

Department of Medicine, University of California, San Francisco, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

10483990

Citation

Terdiman, J P., et al. "Genetic Testing in Hereditary Colorectal Cancer: Indications and Procedures." The American Journal of Gastroenterology, vol. 94, no. 9, 1999, pp. 2344-56.
Terdiman JP, Conrad PG, Sleisenger MH. Genetic testing in hereditary colorectal cancer: indications and procedures. Am J Gastroenterol. 1999;94(9):2344-56.
Terdiman, J. P., Conrad, P. G., & Sleisenger, M. H. (1999). Genetic testing in hereditary colorectal cancer: indications and procedures. The American Journal of Gastroenterology, 94(9), 2344-56.
Terdiman JP, Conrad PG, Sleisenger MH. Genetic Testing in Hereditary Colorectal Cancer: Indications and Procedures. Am J Gastroenterol. 1999;94(9):2344-56. PubMed PMID: 10483990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic testing in hereditary colorectal cancer: indications and procedures. AU - Terdiman,J P, AU - Conrad,P G, AU - Sleisenger,M H, PY - 1999/9/14/pubmed PY - 1999/9/14/medline PY - 1999/9/14/entrez SP - 2344 EP - 56 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 94 IS - 9 N2 - Approximately 25% of colorectal cancers occur in younger individuals or those with a personal or family history of the disease, suggesting a heritable susceptibility. The minority of these cases are accounted for by one of the well-described hereditary colorectal cancer syndromes, familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). The recent identification and cloning of the genes responsible for FAP and HNPCC, along with other colon cancer susceptibility genes, has led to the wide-spread availability of genetic testing for hereditary colorectal cancer. Genetic testing raises clinical, ethical, legal, and psychosocial questions that must urgently be discussed. This review highlights areas of knowledge and uncertainty about genetic predisposition testing for colorectal cancer and provides clinicians with practical recommendations regarding the proper indications and procedures for this testing. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10483990/Genetic_testing_in_hereditary_colorectal_cancer:_indications_and_procedures_ L2 - http://Insights.ovid.com/pubmed?pmid=10483990 DB - PRIME DP - Unbound Medicine ER -