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Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis.
Am J Gastroenterol 1999; 94(9):2373-9AJ

Abstract

OBJECTIVE

As conflicting studies have recently been published, we aimed to determine if Helicobacter pylori (H. pylori) infection is associated with gastric adenocarcinoma.

METHODS

This was a meta-analysis of observational epidemiological studies.

RESULTS

A total of 42 studies met the selection criteria and were categorized by the type of study design: eight cohort and 34 case-control studies. The pooled odds ratio for H. pylori in relation to gastric carcinoma was 2.04 (95% CI: 1.69-2.45). Both patient age (OR 0.77, 95% CI: 0.68-0.89) and intestinal type cancers (OR 1.14, 95% CI: 1.05-1.25) were independent effect modifiers. Analysis of other effect modifiers showed no relationship with female gender (OR 0.76, 95% CI: 0.64-0.89), stage of cancer (advanced %) (OR 1.12, 95% CI: 0.88-1.43), anatomical location (cardia %) (OR 1.54, 95% CI: 0.32-7.39) or cohort (nested case-control) studies (OR 1.72, 95% CI: 0.32-9.17). There was significant heterogeneity among the studies (tau2 = 149; p < 0.001). The quality of the studies varied considerably, with the majority of excellent studies producing positive results and the very poor to moderate studies producing mixed results.

CONCLUSIONS

H. pylori infection is associated with a 2-fold increased risk of developing gastric adenocarcinoma.

Authors+Show Affiliations

Centre for Clinical Epidemiology and Biostatistics, Royal Newcastle Hospital, The University of Newcastle, Australia.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

10483994

Citation

Eslick, G D., et al. "Association of Helicobacter Pylori Infection With Gastric Carcinoma: a Meta-analysis." The American Journal of Gastroenterology, vol. 94, no. 9, 1999, pp. 2373-9.
Eslick GD, Lim LL, Byles JE, et al. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol. 1999;94(9):2373-9.
Eslick, G. D., Lim, L. L., Byles, J. E., Xia, H. H., & Talley, N. J. (1999). Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. The American Journal of Gastroenterology, 94(9), pp. 2373-9.
Eslick GD, et al. Association of Helicobacter Pylori Infection With Gastric Carcinoma: a Meta-analysis. Am J Gastroenterol. 1999;94(9):2373-9. PubMed PMID: 10483994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. AU - Eslick,G D, AU - Lim,L L, AU - Byles,J E, AU - Xia,H H, AU - Talley,N J, PY - 1999/9/14/pubmed PY - 1999/9/14/medline PY - 1999/9/14/entrez SP - 2373 EP - 9 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 94 IS - 9 N2 - OBJECTIVE: As conflicting studies have recently been published, we aimed to determine if Helicobacter pylori (H. pylori) infection is associated with gastric adenocarcinoma. METHODS: This was a meta-analysis of observational epidemiological studies. RESULTS: A total of 42 studies met the selection criteria and were categorized by the type of study design: eight cohort and 34 case-control studies. The pooled odds ratio for H. pylori in relation to gastric carcinoma was 2.04 (95% CI: 1.69-2.45). Both patient age (OR 0.77, 95% CI: 0.68-0.89) and intestinal type cancers (OR 1.14, 95% CI: 1.05-1.25) were independent effect modifiers. Analysis of other effect modifiers showed no relationship with female gender (OR 0.76, 95% CI: 0.64-0.89), stage of cancer (advanced %) (OR 1.12, 95% CI: 0.88-1.43), anatomical location (cardia %) (OR 1.54, 95% CI: 0.32-7.39) or cohort (nested case-control) studies (OR 1.72, 95% CI: 0.32-9.17). There was significant heterogeneity among the studies (tau2 = 149; p < 0.001). The quality of the studies varied considerably, with the majority of excellent studies producing positive results and the very poor to moderate studies producing mixed results. CONCLUSIONS: H. pylori infection is associated with a 2-fold increased risk of developing gastric adenocarcinoma. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10483994/Association_of_Helicobacter_pylori_infection_with_gastric_carcinoma:_a_meta_analysis_ L2 - http://Insights.ovid.com/pubmed?pmid=10483994 DB - PRIME DP - Unbound Medicine ER -