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Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins.
Metabolism. 1999 Sep; 48(9):1120-7.M

Abstract

There are few reports of the change in sex hormone levels accompanying a weight change in men, although an excessive decline in testosterone (TESTO) has been described as an associate of stress-induced weight loss. Plasma levels of cortisol, TESTO, dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA-S), androsterone glucuronide (ADT-G), and androstane-3alpha, 17beta-diol glucuronide (3alphaDIOL-G) were measured in seven pairs of sedentary male monozygotic twins (age, 21.0 +/- 0.8 years; body mass index [BMI], 26.2 +/- 5.5 kg/m2) before and after 93 days of standardized submaximal (50% to 55% maximum oxygen consumption) cycle-ergometer exercise. A total energy deficit of 244 +/- 9.7 MJ induced significant changes (P < .0001) in body weight ([BW] -5.0 +/- 2.2 kg) and body fatness measures. Plasma TESTO and DHEA-S increased and 3alphaDIOL-G decreased. The increase in TESTO was a significant inverse correlate of loss in all measures of body fat, particularly central adiposity (r = -.58 to -.86, P < .001, fat loss-adjusted). Lower postexercise levels of 3alphaDIOL-G correlated positively with decreased body composition measures (r = .65 to .68, P < .01). The increase in plasma TESTO accompanying the loss of abdominal visceral fat (AVF) was greater in men with lower fasting insulin levels (P < .0001). The baseline within-twin-pair resemblance in TESTO and 3alphaDIOL-G (intraclass correlation coefficients [ICC] = .83 and .78, respectively, P < .01) was lost with intervention. Cortisol, DHEA-S, and ADT-G developed within-twin-pair similarity (ICC adjusted for fat loss: cortisol, .72; ADT-G, .62, P < .05; DHEA-S, .85, P < .002). We conclude that a steroid profile characterized by high TESTO and low androgen metabolite levels accompanied the changes in body composition and body fat distribution generated by the exercise-induced negative energy balance. Furthermore, these changes were characterized by a significant resemblance within identical-twin pairs.

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Authors+Show Affiliations

Pritchard J
Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria, Australia.
Després JP
No affiliation info available
Gagnon J
No affiliation info available
Tchernof A
No affiliation info available
Nadeau A
No affiliation info available
Tremblay A
No affiliation info available
Bouchard C
No affiliation info available

MeSH

AdultAndrostane-3,17-diolAndrosteroneBody CompositionDehydroepiandrosterone SulfateDihydrotestosteroneEnergy MetabolismExerciseHumansHydrocortisoneInsulinMaleSteroidsTestosteroneTwins, MonozygoticWeight Loss

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10484051

Citation

Pritchard, J, et al. "Plasma Adrenal, Gonadal, and Conjugated Steroids Following Long-term Exercise-induced Negative Energy Balance in Identical Twins." Metabolism: Clinical and Experimental, vol. 48, no. 9, 1999, pp. 1120-7.
Pritchard J, Després JP, Gagnon J, et al. Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins. Metabolism. 1999;48(9):1120-7.
Pritchard, J., Després, J. P., Gagnon, J., Tchernof, A., Nadeau, A., Tremblay, A., & Bouchard, C. (1999). Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins. Metabolism: Clinical and Experimental, 48(9), 1120-7.
Pritchard J, et al. Plasma Adrenal, Gonadal, and Conjugated Steroids Following Long-term Exercise-induced Negative Energy Balance in Identical Twins. Metabolism. 1999;48(9):1120-7. PubMed PMID: 10484051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins. AU - Pritchard,J, AU - Després,J P, AU - Gagnon,J, AU - Tchernof,A, AU - Nadeau,A, AU - Tremblay,A, AU - Bouchard,C, PY - 1999/9/14/pubmed PY - 1999/9/14/medline PY - 1999/9/14/entrez SP - 1120 EP - 7 JF - Metabolism: clinical and experimental JO - Metabolism VL - 48 IS - 9 N2 - There are few reports of the change in sex hormone levels accompanying a weight change in men, although an excessive decline in testosterone (TESTO) has been described as an associate of stress-induced weight loss. Plasma levels of cortisol, TESTO, dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA-S), androsterone glucuronide (ADT-G), and androstane-3alpha, 17beta-diol glucuronide (3alphaDIOL-G) were measured in seven pairs of sedentary male monozygotic twins (age, 21.0 +/- 0.8 years; body mass index [BMI], 26.2 +/- 5.5 kg/m2) before and after 93 days of standardized submaximal (50% to 55% maximum oxygen consumption) cycle-ergometer exercise. A total energy deficit of 244 +/- 9.7 MJ induced significant changes (P < .0001) in body weight ([BW] -5.0 +/- 2.2 kg) and body fatness measures. Plasma TESTO and DHEA-S increased and 3alphaDIOL-G decreased. The increase in TESTO was a significant inverse correlate of loss in all measures of body fat, particularly central adiposity (r = -.58 to -.86, P < .001, fat loss-adjusted). Lower postexercise levels of 3alphaDIOL-G correlated positively with decreased body composition measures (r = .65 to .68, P < .01). The increase in plasma TESTO accompanying the loss of abdominal visceral fat (AVF) was greater in men with lower fasting insulin levels (P < .0001). The baseline within-twin-pair resemblance in TESTO and 3alphaDIOL-G (intraclass correlation coefficients [ICC] = .83 and .78, respectively, P < .01) was lost with intervention. Cortisol, DHEA-S, and ADT-G developed within-twin-pair similarity (ICC adjusted for fat loss: cortisol, .72; ADT-G, .62, P < .05; DHEA-S, .85, P < .002). We conclude that a steroid profile characterized by high TESTO and low androgen metabolite levels accompanied the changes in body composition and body fat distribution generated by the exercise-induced negative energy balance. Furthermore, these changes were characterized by a significant resemblance within identical-twin pairs. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/10484051/Plasma_adrenal_gonadal_and_conjugated_steroids_following_long_term_exercise_induced_negative_energy_balance_in_identical_twins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(99)90125-7 DB - PRIME DP - Unbound Medicine ER -