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[Is digoxin effective in the treatment of heart insufficiency in patients with sinus rhythm?].
Ugeskr Laeger. 1999 May 31; 161(22):3269-74.UL

Abstract

Since its introduction in 1785, digitalis has been the cornerstone in the treatment of heart failure, although there during the last 20 years have been an increasing number of critical voices questioning its use in patients with sinus rhythm. In 1997 the Digitalis Investigation Group published the so far largest randomized trial on the use of digoxin in patients with heart failure (DIG-trial). All the included patients had sinus rhythm, and all received an ACE-inhibitor. Digoxin had no effect on mortality, but caused a decrease in hospitalizations. Based on the DIG-study, several minor clinical trials and two large withdrawal studies (RADIANCE and PROVED) it now seems clear that digoxin still has a role in the management of heart failure, not only in patients with atrial fibrillation, but also in patients with sinus rhythm.

Authors+Show Affiliations

H:S Bispebjerg Hospital, Medicinsk Center.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dan

PubMed ID

10485204

Citation

Henriksen, O M., and N Gadsbøll. "[Is Digoxin Effective in the Treatment of Heart Insufficiency in Patients With Sinus Rhythm?]." Ugeskrift for Laeger, vol. 161, no. 22, 1999, pp. 3269-74.
Henriksen OM, Gadsbøll N. [Is digoxin effective in the treatment of heart insufficiency in patients with sinus rhythm?]. Ugeskr Laeg. 1999;161(22):3269-74.
Henriksen, O. M., & Gadsbøll, N. (1999). [Is digoxin effective in the treatment of heart insufficiency in patients with sinus rhythm?]. Ugeskrift for Laeger, 161(22), 3269-74.
Henriksen OM, Gadsbøll N. [Is Digoxin Effective in the Treatment of Heart Insufficiency in Patients With Sinus Rhythm?]. Ugeskr Laeg. 1999 May 31;161(22):3269-74. PubMed PMID: 10485204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Is digoxin effective in the treatment of heart insufficiency in patients with sinus rhythm?]. AU - Henriksen,O M, AU - Gadsbøll,N, PY - 1999/9/15/pubmed PY - 1999/9/15/medline PY - 1999/9/15/entrez SP - 3269 EP - 74 JF - Ugeskrift for laeger JO - Ugeskr. Laeg. VL - 161 IS - 22 N2 - Since its introduction in 1785, digitalis has been the cornerstone in the treatment of heart failure, although there during the last 20 years have been an increasing number of critical voices questioning its use in patients with sinus rhythm. In 1997 the Digitalis Investigation Group published the so far largest randomized trial on the use of digoxin in patients with heart failure (DIG-trial). All the included patients had sinus rhythm, and all received an ACE-inhibitor. Digoxin had no effect on mortality, but caused a decrease in hospitalizations. Based on the DIG-study, several minor clinical trials and two large withdrawal studies (RADIANCE and PROVED) it now seems clear that digoxin still has a role in the management of heart failure, not only in patients with atrial fibrillation, but also in patients with sinus rhythm. SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/10485204/[Is_digoxin_effective_in_the_treatment_of_heart_insufficiency_in_patients_with_sinus_rhythm]_ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -