Tags

Type your tag names separated by a space and hit enter

Prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess.
Am J Obstet Gynecol. 1999 Sep; 181(3):596-600.AJ

Abstract

OBJECTIVE

We sought to determine the prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia among adult hyperandrogenic women with dehydroepiandrosterone sulfate excess.

STUDY DESIGN

Thirty consecutive hyperandrogenic women with hirsutism, oligomenorrhea, or both and dehydroepiandrosterone sulfate levels of >8.5 micromol/L and 24 control subjects were studied. Basal sex hormone binding globulin, total and free testosterone, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, and basal and 60-minute corticotropin-stimulated 17-hydroxypregnenolone and dehydroepiandrosterone were measured, and the increment (change from basal to 60-minute value) was calculated.

RESULTS

Twenty-six (87%) and 25 (83%) of the 30 hyperandrogenic patients studied had 60-minute dehydroepiandrosterone and change in 0- to 60-minute dehydroepiandrosterone levels greater than the mean + 2 SD of control subjects, respectively. Six (20%) and 6 (20%) of the 30 hyperandrogenic patients had 60-minute 17-hydroxypregnenolone and 0- to 60-minute change in 17-hydroxypregnenolone levels greater than the mean + 2 SD of control subjects, respectively. However, none of the subjects had either 60-minute 17-hydroxypregnenolone levels or 60-minute dehydroepiandrosterone levels or both associated with the diagnosis of genetically proved 3beta-hydroxysteroid dehydrogenase deficiency (>5-fold of the control mean value).

CONCLUSION

3beta-Hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia is rare even among adult hyperandrogenic patients with adrenal androgen excess.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Moran C
Department of Obstetrics, The University of Alabama at Birmingham, USA.
Potter HD
No affiliation info available
Reyna R
No affiliation info available
Boots LR
No affiliation info available
Azziz R
No affiliation info available

MeSH

17-alpha-Hydroxyprogesterone3-Hydroxysteroid DehydrogenasesAdolescentAdrenal Hyperplasia, CongenitalAdrenocorticotropic HormoneAdultDehydroepiandrosteroneDehydroepiandrosterone SulfateFemaleHumansHyperandrogenismKineticsTestosterone

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10486469

Citation

Moran, C, et al. "Prevalence of 3beta-hydroxysteroid Dehydrogenase-deficient Nonclassic Adrenal Hyperplasia in Hyperandrogenic Women With Adrenal Androgen Excess." American Journal of Obstetrics and Gynecology, vol. 181, no. 3, 1999, pp. 596-600.
Moran C, Potter HD, Reyna R, et al. Prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess. Am J Obstet Gynecol. 1999;181(3):596-600.
Moran, C., Potter, H. D., Reyna, R., Boots, L. R., & Azziz, R. (1999). Prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess. American Journal of Obstetrics and Gynecology, 181(3), 596-600.
Moran C, et al. Prevalence of 3beta-hydroxysteroid Dehydrogenase-deficient Nonclassic Adrenal Hyperplasia in Hyperandrogenic Women With Adrenal Androgen Excess. Am J Obstet Gynecol. 1999;181(3):596-600. PubMed PMID: 10486469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with adrenal androgen excess. AU - Moran,C, AU - Potter,H D, AU - Reyna,R, AU - Boots,L R, AU - Azziz,R, PY - 1999/9/16/pubmed PY - 1999/9/16/medline PY - 1999/9/16/entrez SP - 596 EP - 600 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 181 IS - 3 N2 - OBJECTIVE: We sought to determine the prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia among adult hyperandrogenic women with dehydroepiandrosterone sulfate excess. STUDY DESIGN: Thirty consecutive hyperandrogenic women with hirsutism, oligomenorrhea, or both and dehydroepiandrosterone sulfate levels of >8.5 micromol/L and 24 control subjects were studied. Basal sex hormone binding globulin, total and free testosterone, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, and basal and 60-minute corticotropin-stimulated 17-hydroxypregnenolone and dehydroepiandrosterone were measured, and the increment (change from basal to 60-minute value) was calculated. RESULTS: Twenty-six (87%) and 25 (83%) of the 30 hyperandrogenic patients studied had 60-minute dehydroepiandrosterone and change in 0- to 60-minute dehydroepiandrosterone levels greater than the mean + 2 SD of control subjects, respectively. Six (20%) and 6 (20%) of the 30 hyperandrogenic patients had 60-minute 17-hydroxypregnenolone and 0- to 60-minute change in 17-hydroxypregnenolone levels greater than the mean + 2 SD of control subjects, respectively. However, none of the subjects had either 60-minute 17-hydroxypregnenolone levels or 60-minute dehydroepiandrosterone levels or both associated with the diagnosis of genetically proved 3beta-hydroxysteroid dehydrogenase deficiency (>5-fold of the control mean value). CONCLUSION: 3beta-Hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia is rare even among adult hyperandrogenic patients with adrenal androgen excess. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/10486469/Prevalence_of_3beta_hydroxysteroid_dehydrogenase_deficient_nonclassic_adrenal_hyperplasia_in_hyperandrogenic_women_with_adrenal_androgen_excess_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937899704989 DB - PRIME DP - Unbound Medicine ER -