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The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia.
Am J Obstet Gynecol. 1999 Sep; 181(3):638-41.AJ

Abstract

OBJECTIVE

We attempted to determine the role of endothelin in a previously characterized animal model of preeclampsia by studying the effect of a specific endothelin antagonist, BQ123, on blood pressure.

STUDY DESIGN

A preeclampsia-like condition was induced by infusing pregnant rats with the nitric oxide synthase inhibitor N(G)-nitro-L -arginine methyl ester. Osmotic minipumps were inserted subcutaneously into timed pregnant Harlan-Sprague-Dawley rats on day 17 of pregnancy (term, 22 days). The pumps were loaded to continuously deliver either vehicle (control group) or N(G)-nitro-L -arginine methyl ester 50 mg/d, either alone or with BQ123 at 0.5 mg/d. In a similar but separate experiment, the dose of BQ123 was increased to 1 mg/d. Blood pressure was measured with the tail-cuff method before pump insertion and then daily until postpartum day 2.

RESULTS

Except for a decrease on the day after pump insertion, BQ123 0.5 mg/d had no significant effect on the hypertension induced by N(G)-nitro-L -arginine methyl ester. At the higher dose, however, BQ123 significantly attenuated the increase in blood pressure induced by N(G)-nitro-L -arginine methyl ester during most of the study period.

CONCLUSION

The effect of nitric oxide inhibition can be successfully attenuated by the use of an endothelin antagonist, thereby supporting the role of endothelin in the hypertension described with the preeclampsialike condition seen in pregnant rats.

Authors+Show Affiliations

Division of Materna;-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10486477

Citation

Olson, G L., et al. "The Effect of an Endothelin Antagonist On Blood Pressure in a Rat Model of Preeclampsia." American Journal of Obstetrics and Gynecology, vol. 181, no. 3, 1999, pp. 638-41.
Olson GL, Saade GR, Buhimschi I, et al. The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia. Am J Obstet Gynecol. 1999;181(3):638-41.
Olson, G. L., Saade, G. R., Buhimschi, I., Chwalisz, K., & Garfield, R. E. (1999). The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia. American Journal of Obstetrics and Gynecology, 181(3), 638-41.
Olson GL, et al. The Effect of an Endothelin Antagonist On Blood Pressure in a Rat Model of Preeclampsia. Am J Obstet Gynecol. 1999;181(3):638-41. PubMed PMID: 10486477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia. AU - Olson,G L, AU - Saade,G R, AU - Buhimschi,I, AU - Chwalisz,K, AU - Garfield,R E, PY - 1999/9/16/pubmed PY - 1999/9/16/medline PY - 1999/9/16/entrez SP - 638 EP - 41 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 181 IS - 3 N2 - OBJECTIVE: We attempted to determine the role of endothelin in a previously characterized animal model of preeclampsia by studying the effect of a specific endothelin antagonist, BQ123, on blood pressure. STUDY DESIGN: A preeclampsia-like condition was induced by infusing pregnant rats with the nitric oxide synthase inhibitor N(G)-nitro-L -arginine methyl ester. Osmotic minipumps were inserted subcutaneously into timed pregnant Harlan-Sprague-Dawley rats on day 17 of pregnancy (term, 22 days). The pumps were loaded to continuously deliver either vehicle (control group) or N(G)-nitro-L -arginine methyl ester 50 mg/d, either alone or with BQ123 at 0.5 mg/d. In a similar but separate experiment, the dose of BQ123 was increased to 1 mg/d. Blood pressure was measured with the tail-cuff method before pump insertion and then daily until postpartum day 2. RESULTS: Except for a decrease on the day after pump insertion, BQ123 0.5 mg/d had no significant effect on the hypertension induced by N(G)-nitro-L -arginine methyl ester. At the higher dose, however, BQ123 significantly attenuated the increase in blood pressure induced by N(G)-nitro-L -arginine methyl ester during most of the study period. CONCLUSION: The effect of nitric oxide inhibition can be successfully attenuated by the use of an endothelin antagonist, thereby supporting the role of endothelin in the hypertension described with the preeclampsialike condition seen in pregnant rats. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/10486477/The_effect_of_an_endothelin_antagonist_on_blood_pressure_in_a_rat_model_of_preeclampsia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937899705065 DB - PRIME DP - Unbound Medicine ER -