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Thiamin deficiency and Korsakoff's syndrome: failure to find memory impairments following nonalcoholic Wernicke's encephalopathy.
Alcohol. 1999 Aug; 19(1):75-84.A

Abstract

Prolonged alcohol consumption is associated with a variety of neuropsychiatric conditions, including the dense amnesic disorder known as Korsakoff's syndrome. Korsakoff's syndrome is frequently diagnosed in alcoholics after an episode of acute thiamin deficiency. The accepted view within the medical literature is that the etiology of this disorder lies in thiamin deficiency or Wernicke's encephalopathy. However, examination of the published reports of pure thiamin deficiency unaccompanied by chronic and excessive consumption of alcohol shows that, in this group of patients, the rate of progression to Korsakoff's syndrome is low. This result suggests that the memory impairments associated with alcohol-related brain damage cannot be attributed to thiamin deficiency alone. The etiology of alcohol-related cognitive impairments such as Korsakoff's syndrome is still poorly understood but several lines of evidence suggest multiple causal factors interact to produce deficits in performance. Animal models that manipulate only a single putative etiological factor are unlikely to elucidate the multiple influences that lead to Korsakoff's syndrome. A study of the natural history of alcohol-related brain damage is needed that will allow an assessment of individual risk factors and their interactions.

Authors+Show Affiliations

Department of Psychology, Macquarie University, Sydney, Australia. homewood@bunyip.bhs.mq.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10487391

Citation

Homewood, J, and N W. Bond. "Thiamin Deficiency and Korsakoff's Syndrome: Failure to Find Memory Impairments Following Nonalcoholic Wernicke's Encephalopathy." Alcohol (Fayetteville, N.Y.), vol. 19, no. 1, 1999, pp. 75-84.
Homewood J, Bond NW. Thiamin deficiency and Korsakoff's syndrome: failure to find memory impairments following nonalcoholic Wernicke's encephalopathy. Alcohol. 1999;19(1):75-84.
Homewood, J., & Bond, N. W. (1999). Thiamin deficiency and Korsakoff's syndrome: failure to find memory impairments following nonalcoholic Wernicke's encephalopathy. Alcohol (Fayetteville, N.Y.), 19(1), 75-84.
Homewood J, Bond NW. Thiamin Deficiency and Korsakoff's Syndrome: Failure to Find Memory Impairments Following Nonalcoholic Wernicke's Encephalopathy. Alcohol. 1999;19(1):75-84. PubMed PMID: 10487391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thiamin deficiency and Korsakoff's syndrome: failure to find memory impairments following nonalcoholic Wernicke's encephalopathy. AU - Homewood,J, AU - Bond,N W, PY - 1999/9/16/pubmed PY - 1999/9/16/medline PY - 1999/9/16/entrez SP - 75 EP - 84 JF - Alcohol (Fayetteville, N.Y.) JO - Alcohol VL - 19 IS - 1 N2 - Prolonged alcohol consumption is associated with a variety of neuropsychiatric conditions, including the dense amnesic disorder known as Korsakoff's syndrome. Korsakoff's syndrome is frequently diagnosed in alcoholics after an episode of acute thiamin deficiency. The accepted view within the medical literature is that the etiology of this disorder lies in thiamin deficiency or Wernicke's encephalopathy. However, examination of the published reports of pure thiamin deficiency unaccompanied by chronic and excessive consumption of alcohol shows that, in this group of patients, the rate of progression to Korsakoff's syndrome is low. This result suggests that the memory impairments associated with alcohol-related brain damage cannot be attributed to thiamin deficiency alone. The etiology of alcohol-related cognitive impairments such as Korsakoff's syndrome is still poorly understood but several lines of evidence suggest multiple causal factors interact to produce deficits in performance. Animal models that manipulate only a single putative etiological factor are unlikely to elucidate the multiple influences that lead to Korsakoff's syndrome. A study of the natural history of alcohol-related brain damage is needed that will allow an assessment of individual risk factors and their interactions. SN - 0741-8329 UR - https://www.unboundmedicine.com/medline/citation/10487391/Thiamin_deficiency_and_Korsakoff's_syndrome:_failure_to_find_memory_impairments_following_nonalcoholic_Wernicke's_encephalopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741-8329(99)00027-0 DB - PRIME DP - Unbound Medicine ER -