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Sex hormones and headache 1999 (menstrual migraine).
Neurology. 1999; 53(4 Suppl 1):S3-13.Neur

Abstract

The normal female life cycle is associated with a number of hormonal milestones: menarche, pregnancy, contraceptive use, menopause, and the use of replacement sex hormones. All these events and interventions alter the levels and cycling of sex hormones and may cause a change in the prevalence or intensity of headache. The menstrual cycle is the result of a carefully orchestrated sequence of interactions among the hypothalamus, pituitary, ovary, and endometrium, with the sex hormones acting as modulators and effectors at each level. Estrogen and progestins have potent effects on central serotonergic and opioid neurons, modulating both neuronal activity and receptor density. The primary trigger of menstrual migraine appears to be the withdrawal of estrogen rather than the maintenance of sustained high or low estrogen levels. However, changes in the sustained estrogen levels with pregnancy (increased) and menopause (decreased) appear to affect headaches. Headaches that occur with premenstrual syndrome appear to be centrally generated, involving the inherent rhythm of CNS neurons, including perhaps the serotonergic pain-modulating systems.

Authors+Show Affiliations

Thomas Jefferson University School of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10487507

Citation

Silberstein, S, and G Merriam. "Sex Hormones and Headache 1999 (menstrual Migraine)." Neurology, vol. 53, no. 4 Suppl 1, 1999, pp. S3-13.
Silberstein S, Merriam G. Sex hormones and headache 1999 (menstrual migraine). Neurology. 1999;53(4 Suppl 1):S3-13.
Silberstein, S., & Merriam, G. (1999). Sex hormones and headache 1999 (menstrual migraine). Neurology, 53(4 Suppl 1), S3-13.
Silberstein S, Merriam G. Sex Hormones and Headache 1999 (menstrual Migraine). Neurology. 1999;53(4 Suppl 1):S3-13. PubMed PMID: 10487507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex hormones and headache 1999 (menstrual migraine). AU - Silberstein,S, AU - Merriam,G, PY - 1999/9/16/pubmed PY - 1999/9/16/medline PY - 1999/9/16/entrez SP - S3 EP - 13 JF - Neurology JO - Neurology VL - 53 IS - 4 Suppl 1 N2 - The normal female life cycle is associated with a number of hormonal milestones: menarche, pregnancy, contraceptive use, menopause, and the use of replacement sex hormones. All these events and interventions alter the levels and cycling of sex hormones and may cause a change in the prevalence or intensity of headache. The menstrual cycle is the result of a carefully orchestrated sequence of interactions among the hypothalamus, pituitary, ovary, and endometrium, with the sex hormones acting as modulators and effectors at each level. Estrogen and progestins have potent effects on central serotonergic and opioid neurons, modulating both neuronal activity and receptor density. The primary trigger of menstrual migraine appears to be the withdrawal of estrogen rather than the maintenance of sustained high or low estrogen levels. However, changes in the sustained estrogen levels with pregnancy (increased) and menopause (decreased) appear to affect headaches. Headaches that occur with premenstrual syndrome appear to be centrally generated, involving the inherent rhythm of CNS neurons, including perhaps the serotonergic pain-modulating systems. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/10487507/Sex_hormones_and_headache_1999__menstrual_migraine__ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10487507.ui DB - PRIME DP - Unbound Medicine ER -
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