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Influenza A among community-dwelling elderly persons in Leicestershire during winter 1993-4; cigarette smoking as a risk factor and the efficacy of influenza vaccination.

Abstract

In a prospective study of community-dwelling people 60-90 years of age, we examined the coverage of influenza vaccine during 1992-3 and 1993-4, the efficacy of vaccination in reducing serologically-confirmed clinical episodes of influenza A during 1993, and the effect of cigarette smoking. During 1992 and 1993, influenza vaccine was given to 106/215 (49%) and 120/204 (59%) people with risk conditions, and 84/225 (37%) and 103/235 (44%) without risk conditions. Influenza vaccination and general practitioner consultations during 1992 were independent predictors of vaccination in 1993, but current smoking was a negative predictor. Of 209 unimmunized people, 8/35 (23%) smokers had clinical influenza as compared with 11/174 (6%) non-smokers (OR 4.4, 95% CI 1.6 to 11.9). Of 371 non-smokers, 1/197 (0.5%) vaccinees had influenza as compared with 11/174 (6%) non-vaccinees (OR 0.075, 95% CI 0.587 to 0.009). No cases of influenza occurred among 21 current smokers who were vaccinated.

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  • Authors+Show Affiliations

    ,

    Infectious and Tropical Diseases Unit, Leicester Royal Infirmary, UK.

    ,

    Source

    Epidemiology and infection 123:1 1999 Aug pg 103-8

    MeSH

    Aged
    Aged, 80 and over
    England
    Female
    Housing for the Elderly
    Humans
    Influenza A virus
    Influenza Vaccines
    Influenza, Human
    Logistic Models
    Male
    Middle Aged
    Prospective Studies
    Risk Factors
    Smoking
    Vaccination

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10487646

    Citation

    Nicholson, K G., et al. "Influenza a Among Community-dwelling Elderly Persons in Leicestershire During Winter 1993-4; Cigarette Smoking as a Risk Factor and the Efficacy of Influenza Vaccination." Epidemiology and Infection, vol. 123, no. 1, 1999, pp. 103-8.
    Nicholson KG, Kent J, Hammersley V. Influenza A among community-dwelling elderly persons in Leicestershire during winter 1993-4; cigarette smoking as a risk factor and the efficacy of influenza vaccination. Epidemiol Infect. 1999;123(1):103-8.
    Nicholson, K. G., Kent, J., & Hammersley, V. (1999). Influenza A among community-dwelling elderly persons in Leicestershire during winter 1993-4; cigarette smoking as a risk factor and the efficacy of influenza vaccination. Epidemiology and Infection, 123(1), pp. 103-8.
    Nicholson KG, Kent J, Hammersley V. Influenza a Among Community-dwelling Elderly Persons in Leicestershire During Winter 1993-4; Cigarette Smoking as a Risk Factor and the Efficacy of Influenza Vaccination. Epidemiol Infect. 1999;123(1):103-8. PubMed PMID: 10487646.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Influenza A among community-dwelling elderly persons in Leicestershire during winter 1993-4; cigarette smoking as a risk factor and the efficacy of influenza vaccination. AU - Nicholson,K G, AU - Kent,J, AU - Hammersley,V, PY - 1999/9/16/pubmed PY - 1999/9/16/medline PY - 1999/9/16/entrez SP - 103 EP - 8 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 123 IS - 1 N2 - In a prospective study of community-dwelling people 60-90 years of age, we examined the coverage of influenza vaccine during 1992-3 and 1993-4, the efficacy of vaccination in reducing serologically-confirmed clinical episodes of influenza A during 1993, and the effect of cigarette smoking. During 1992 and 1993, influenza vaccine was given to 106/215 (49%) and 120/204 (59%) people with risk conditions, and 84/225 (37%) and 103/235 (44%) without risk conditions. Influenza vaccination and general practitioner consultations during 1992 were independent predictors of vaccination in 1993, but current smoking was a negative predictor. Of 209 unimmunized people, 8/35 (23%) smokers had clinical influenza as compared with 11/174 (6%) non-smokers (OR 4.4, 95% CI 1.6 to 11.9). Of 371 non-smokers, 1/197 (0.5%) vaccinees had influenza as compared with 11/174 (6%) non-vaccinees (OR 0.075, 95% CI 0.587 to 0.009). No cases of influenza occurred among 21 current smokers who were vaccinated. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/10487646/Influenza_A_among_community_dwelling_elderly_persons_in_Leicestershire_during_winter_1993_4 L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/10487646/ DB - PRIME DP - Unbound Medicine ER -