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[Significance of eosinophilic granulocytes in relation to allergy and aspirin intolerance in patients with sinusitis polyposa].
Laryngorhinootologie. 1999 Aug; 78(8):429-34.L

Abstract

BACKGROUND

The development of nasal polyps might be influenced by different factors such as mucosal inflammation. Infiltration with eosinophils is a common finding, although in largely different quantitis.

PATIENTS AND METHODS

We investigated 58 patients suffering from nasal polyps who were assigned for endonasal sinus surgery based on endoscopic and CT findings. Out of these patients, 52% have already had sinus surgery and had recurrent polyps. All patients were subjected to both, allergy testing and a functional in vitro test for aspirin intolerance. During surgery, tissue samples were gained and send for histological examination with special respect to eosinophil infiltration.

RESULTS

Eosinophil infiltration was observed in 66% of all patients. 37 patients (64%) exhibited aspirin intolerance only, four (7%) had a positive allergy test only, in 9 patients (15%) both, allergy and aspirin intolerance were diagnosed. Allergy and aspirin intolerance were accompanied by eosinophil tissue infiltration. Eosinophil infiltration was more common and more severe if allergy and aspirin intolerance were found together compared with the tissue eosinophilia in patients with either one entity.

CONCLUSION

This study confirms the importance of eosinophil infiltration in the pathogenesis of severe or recurrent nasal polyps based on allergy and aspirin intolerance. A coincidance of allergy and aspirin intolerance was found in an unexpected high number of patients.

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Authors+Show Affiliations

Kaldenbach T
Hals-, Nasen-, Ohrenklinik und Poliklinik der Johannes Gutenberg-Universität Mainz.
Schäfer D
No affiliation info available
Gosepath J
No affiliation info available
Bittinger F
No affiliation info available
Klimek L
No affiliation info available
Mann WJ
No affiliation info available

MeSH

AdultAgedAspirinDrug HypersensitivityEosinophiliaEosinophilsFemaleHumansMaleMiddle AgedNasal MucosaNasal PolypsNasal Provocation TestsRecurrenceReoperationRespiratory HypersensitivityRisk FactorsSinusitis

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

10488462

Citation

Kaldenbach, T, et al. "[Significance of Eosinophilic Granulocytes in Relation to Allergy and Aspirin Intolerance in Patients With Sinusitis Polyposa]." Laryngo- Rhino- Otologie, vol. 78, no. 8, 1999, pp. 429-34.
Kaldenbach T, Schäfer D, Gosepath J, et al. [Significance of eosinophilic granulocytes in relation to allergy and aspirin intolerance in patients with sinusitis polyposa]. Laryngorhinootologie. 1999;78(8):429-34.
Kaldenbach, T., Schäfer, D., Gosepath, J., Bittinger, F., Klimek, L., & Mann, W. J. (1999). [Significance of eosinophilic granulocytes in relation to allergy and aspirin intolerance in patients with sinusitis polyposa]. Laryngo- Rhino- Otologie, 78(8), 429-34.
Kaldenbach T, et al. [Significance of Eosinophilic Granulocytes in Relation to Allergy and Aspirin Intolerance in Patients With Sinusitis Polyposa]. Laryngorhinootologie. 1999;78(8):429-34. PubMed PMID: 10488462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Significance of eosinophilic granulocytes in relation to allergy and aspirin intolerance in patients with sinusitis polyposa]. AU - Kaldenbach,T, AU - Schäfer,D, AU - Gosepath,J, AU - Bittinger,F, AU - Klimek,L, AU - Mann,W J, PY - 1999/9/17/pubmed PY - 1999/9/17/medline PY - 1999/9/17/entrez SP - 429 EP - 34 JF - Laryngo- rhino- otologie JO - Laryngorhinootologie VL - 78 IS - 8 N2 - BACKGROUND: The development of nasal polyps might be influenced by different factors such as mucosal inflammation. Infiltration with eosinophils is a common finding, although in largely different quantitis. PATIENTS AND METHODS: We investigated 58 patients suffering from nasal polyps who were assigned for endonasal sinus surgery based on endoscopic and CT findings. Out of these patients, 52% have already had sinus surgery and had recurrent polyps. All patients were subjected to both, allergy testing and a functional in vitro test for aspirin intolerance. During surgery, tissue samples were gained and send for histological examination with special respect to eosinophil infiltration. RESULTS: Eosinophil infiltration was observed in 66% of all patients. 37 patients (64%) exhibited aspirin intolerance only, four (7%) had a positive allergy test only, in 9 patients (15%) both, allergy and aspirin intolerance were diagnosed. Allergy and aspirin intolerance were accompanied by eosinophil tissue infiltration. Eosinophil infiltration was more common and more severe if allergy and aspirin intolerance were found together compared with the tissue eosinophilia in patients with either one entity. CONCLUSION: This study confirms the importance of eosinophil infiltration in the pathogenesis of severe or recurrent nasal polyps based on allergy and aspirin intolerance. A coincidance of allergy and aspirin intolerance was found in an unexpected high number of patients. SN - 0935-8943 UR - https://www.unboundmedicine.com/medline/citation/10488462/[Significance_of_eosinophilic_granulocytes_in_relation_to_allergy_and_aspirin_intolerance_in_patients_with_sinusitis_polyposa]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-996903 DB - PRIME DP - Unbound Medicine ER -