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Influence of APOE genotype on familial aggregation of AD in an urban population.
Neurology. 1999 Sep 11; 53(4):789-94.Neur

Abstract

OBJECTIVE

To examine the influence of the proband's APOE genotype on AD among first-degree relatives in a community-based study of African Americans, whites, and Caribbean Hispanics.

METHODS

History of AD and demographic information were obtained on 1,073 siblings and parents of 312 patients with AD and 2,722 siblings and parents of 802 nondemented controls. APOE genotyping was performed on all 1,114 patients and controls.

RESULTS

A higher proportion of patients with AD (35%) than controls (27%) had one or more APOE-epsilon4 alleles (p = 0.03). When compared with relatives of controls without an APOE-epsilon4 allele, the risk for AD was increased in first-degree relatives of both patients (rate ratio [RR] = 1.9, 95% confidence interval [CI] = 1.2 to 3.1) and controls (RR = 1.8, 95% CI = 1.2 to 2.6) with one or more APOE-epsilone alleles, regardless of ethnic group. There was a similar trend of increased risk in relatives of patients without an APOE-epsilon4 allele, but this was limited to Hispanics and African Americans.

CONCLUSIONS

The presence of an APOE-epsilon4 allele increases risk for AD among first-degree relatives, regardless of the probands' disease status, among all ethnic groups. Relatives of patients without an APOE-epsilon4 allele were also at increased risk for AD among Hispanics and African Americans, suggesting that other genes or risk factors may influence risk.

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Authors+Show Affiliations

Devi G
Gertrude H. Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, New York, NY 10032, USA.
Ottman R
No affiliation info available
Tang M
No affiliation info available
Marder K
No affiliation info available
Stern Y
No affiliation info available
Tycko B
No affiliation info available
Mayeux R
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseApolipoproteins EFemaleGenotypeHumansMaleMedical History TakingRisk FactorsUrban Population

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10489042

Citation

Devi, G, et al. "Influence of APOE Genotype On Familial Aggregation of AD in an Urban Population." Neurology, vol. 53, no. 4, 1999, pp. 789-94.
Devi G, Ottman R, Tang M, et al. Influence of APOE genotype on familial aggregation of AD in an urban population. Neurology. 1999;53(4):789-94.
Devi, G., Ottman, R., Tang, M., Marder, K., Stern, Y., Tycko, B., & Mayeux, R. (1999). Influence of APOE genotype on familial aggregation of AD in an urban population. Neurology, 53(4), 789-94.
Devi G, et al. Influence of APOE Genotype On Familial Aggregation of AD in an Urban Population. Neurology. 1999 Sep 11;53(4):789-94. PubMed PMID: 10489042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of APOE genotype on familial aggregation of AD in an urban population. AU - Devi,G, AU - Ottman,R, AU - Tang,M, AU - Marder,K, AU - Stern,Y, AU - Tycko,B, AU - Mayeux,R, PY - 1999/9/17/pubmed PY - 1999/9/17/medline PY - 1999/9/17/entrez SP - 789 EP - 94 JF - Neurology JO - Neurology VL - 53 IS - 4 N2 - OBJECTIVE: To examine the influence of the proband's APOE genotype on AD among first-degree relatives in a community-based study of African Americans, whites, and Caribbean Hispanics. METHODS: History of AD and demographic information were obtained on 1,073 siblings and parents of 312 patients with AD and 2,722 siblings and parents of 802 nondemented controls. APOE genotyping was performed on all 1,114 patients and controls. RESULTS: A higher proportion of patients with AD (35%) than controls (27%) had one or more APOE-epsilon4 alleles (p = 0.03). When compared with relatives of controls without an APOE-epsilon4 allele, the risk for AD was increased in first-degree relatives of both patients (rate ratio [RR] = 1.9, 95% confidence interval [CI] = 1.2 to 3.1) and controls (RR = 1.8, 95% CI = 1.2 to 2.6) with one or more APOE-epsilone alleles, regardless of ethnic group. There was a similar trend of increased risk in relatives of patients without an APOE-epsilon4 allele, but this was limited to Hispanics and African Americans. CONCLUSIONS: The presence of an APOE-epsilon4 allele increases risk for AD among first-degree relatives, regardless of the probands' disease status, among all ethnic groups. Relatives of patients without an APOE-epsilon4 allele were also at increased risk for AD among Hispanics and African Americans, suggesting that other genes or risk factors may influence risk. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/10489042/Influence_of_APOE_genotype_on_familial_aggregation_of_AD_in_an_urban_population_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=10489042 DB - PRIME DP - Unbound Medicine ER -